ENSG00000176681

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000320254 ENSG00000176681 HEK293_OSMI2_2hA HEK293_TMG_2hB LRRC37A protein_coding protein_coding 0.6350784 0.4249904 0.5790913 0.03662255 0.03093113 0.4375077 0.06024501 0.12557341 0.00000000 0.009858242 0.000000000 -3.7610023 0.13474583 0.30310000 0.00000000 -0.30310000 0.0003240990 0.000324099 FALSE TRUE
ENST00000496930 ENSG00000176681 HEK293_OSMI2_2hA HEK293_TMG_2hB LRRC37A protein_coding protein_coding 0.6350784 0.4249904 0.5790913 0.03662255 0.03093113 0.4375077 0.07330046 0.08227920 0.02452244 0.033783959 0.014211389 -1.4184712 0.14192917 0.18956667 0.04506667 -0.14450000 0.2428625205 0.000324099 FALSE TRUE
MSTRG.14524.11 ENSG00000176681 HEK293_OSMI2_2hA HEK293_TMG_2hB LRRC37A protein_coding   0.6350784 0.4249904 0.5790913 0.03662255 0.03093113 0.4375077 0.04409618 0.02054473 0.03805129 0.009061721 0.002642211 0.6536518 0.07205000 0.05020000 0.06626667 0.01606667 0.8295149315 0.000324099 TRUE TRUE
MSTRG.14524.13 ENSG00000176681 HEK293_OSMI2_2hA HEK293_TMG_2hB LRRC37A protein_coding   0.6350784 0.4249904 0.5790913 0.03662255 0.03093113 0.4375077 0.03117890 0.03145760 0.03754912 0.031457604 0.014429980 0.1977819 0.06072083 0.08493333 0.06806667 -0.01686667 0.9631536217 0.000324099 TRUE TRUE
MSTRG.14524.14 ENSG00000176681 HEK293_OSMI2_2hA HEK293_TMG_2hB LRRC37A protein_coding   0.6350784 0.4249904 0.5790913 0.03662255 0.03093113 0.4375077 0.10415470 0.03161155 0.11830662 0.031611552 0.064402173 1.6245396 0.12825417 0.06393333 0.19383333 0.12990000 0.7057387967 0.000324099 TRUE TRUE
MSTRG.14524.5 ENSG00000176681 HEK293_OSMI2_2hA HEK293_TMG_2hB LRRC37A protein_coding   0.6350784 0.4249904 0.5790913 0.03662255 0.03093113 0.4375077 0.19487166 0.03650318 0.34152360 0.036503175 0.020034892 2.9182204 0.34755833 0.07380000 0.59393333 0.52013333 0.0006903869 0.000324099 FALSE TRUE
MSTRG.14524.9 ENSG00000176681 HEK293_OSMI2_2hA HEK293_TMG_2hB LRRC37A protein_coding   0.6350784 0.4249904 0.5790913 0.03662255 0.03093113 0.4375077 0.07403349 0.06822906 0.00000000 0.068229056 0.000000000 -2.9677046 0.05008750 0.16640000 0.00000000 -0.16640000 0.6650883128 0.000324099 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000176681 E001 0.0000000       17 46292733 46294029 1297 +      
ENSG00000176681 E002 0.0000000       17 46295099 46295130 32 +      
ENSG00000176681 E003 0.0000000       17 46295131 46297742 2612 +      
ENSG00000176681 E004 0.0000000       17 46299144 46299790 647 +      
ENSG00000176681 E005 0.0000000       17 46299791 46299793 3 +      
ENSG00000176681 E006 0.0000000       17 46299794 46299865 72 +      
ENSG00000176681 E007 0.0000000       17 46302443 46302564 122 +      
ENSG00000176681 E008 0.0000000       17 46302565 46302621 57 +      
ENSG00000176681 E009 0.0000000       17 46302622 46302637 16 +      
ENSG00000176681 E010 0.0000000       17 46302638 46302660 23 +      
ENSG00000176681 E011 0.0000000       17 46302661 46302709 49 +      
ENSG00000176681 E012 0.0000000       17 46305509 46305580 72 +      
ENSG00000176681 E013 0.0000000       17 46306205 46306228 24 +      
ENSG00000176681 E014 0.0000000       17 46306229 46306309 81 +      
ENSG00000176681 E015 0.0000000       17 46321176 46322321 1146 +      
ENSG00000176681 E016 0.0000000       17 46322322 46322393 72 +      
ENSG00000176681 E017 0.0000000       17 46322953 46323027 75 +      
ENSG00000176681 E018 0.0000000       17 46323028 46324912 1885 +      
ENSG00000176681 E019 0.9286724 0.016374617 0.072878455 0.14812408 17 46324913 46328391 3479 + 0.433 0.117 -2.465
ENSG00000176681 E020 0.0000000       17 46328392 46328510 119 +      
ENSG00000176681 E021 0.0000000       17 46328511 46328660 150 +      
ENSG00000176681 E022 0.0000000       17 46328661 46330449 1789 +      
ENSG00000176681 E023 4.1588678 0.004355449 0.101841743 0.19330340 17 46330450 46331981 1532 + 0.572 0.797 0.944
ENSG00000176681 E024 0.0000000       17 46331982 46332551 570 +      
ENSG00000176681 E025 2.0647525 0.008435211 0.002833063 0.00977303 17 46332552 46332656 105 + 0.128 0.644 3.315
ENSG00000176681 E026 0.0000000       17 46332657 46333267 611 +      
ENSG00000176681 E027 0.3686942 0.028420119 0.954403966 0.97543295 17 46333268 46335544 2277 + 0.128 0.117 -0.140
ENSG00000176681 E028 4.4199558 0.004612190 0.716053351 0.81180938 17 46335545 46335594 50 + 0.708 0.752 0.179
ENSG00000176681 E029 0.5848434 0.021861930 0.030304723 0.07256609 17 46335595 46337295 1701 + 0.374 0.000 -11.006
ENSG00000176681 E030 10.4882290 0.002192469 0.867567783 0.91883827 17 46337296 46337350 55 + 1.051 1.062 0.038
ENSG00000176681 E031 1.7359165 0.009736703 0.654219126 0.76446534 17 46337351 46337428 78 + 0.485 0.406 -0.407
ENSG00000176681 E032 17.5726457 0.001203547 0.880380381 0.92728629 17 46337429 46337568 140 + 1.266 1.271 0.017
ENSG00000176681 E033 0.0000000       17 46337569 46337674 106 +      
ENSG00000176681 E034 12.4481864 0.001917303 0.069265187 0.14214771 17 46337675 46340310 2636 + 1.205 1.050 -0.558
ENSG00000176681 E035 0.3729606 0.028425383 0.952969138 0.97456226 17 46340311 46340370 60 + 0.128 0.117 -0.140
ENSG00000176681 E036 1.5908299 0.015871736 0.380268005 0.52455941 17 46340638 46340741 104 + 0.307 0.457 0.859