ENSG00000176476

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000317058 ENSG00000176476 HEK293_OSMI2_2hA HEK293_TMG_2hB SGF29 protein_coding protein_coding 30.2891 48.75254 22.20031 0.6180976 0.2093478 -1.134544 25.450462 43.712839 17.559311 0.6931400 0.2457373 -1.3153295 0.8220583 0.89663333 0.7910333 -0.10560000 2.627074e-06 2.627074e-06 FALSE TRUE
ENST00000567564 ENSG00000176476 HEK293_OSMI2_2hA HEK293_TMG_2hB SGF29 protein_coding nonsense_mediated_decay 30.2891 48.75254 22.20031 0.6180976 0.2093478 -1.134544 2.053714 3.093781 1.661078 0.2950201 0.2284243 -0.8932473 0.0694250 0.06333333 0.0750000 0.01166667 7.573176e-01 2.627074e-06 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000176476 E001 0.1451727 0.0430573645 0.177592102   16 28538437 28538611 175 + 0.186 0.000 -10.360
ENSG00000176476 E002 0.0000000       16 28540566 28540605 40 +      
ENSG00000176476 E003 0.8042123 0.0919856214 0.023285368 0.05834415 16 28553760 28553914 155 + 0.496 0.079 -3.422
ENSG00000176476 E004 0.8105550 0.0149471174 0.014989080 0.04046449 16 28553915 28553919 5 + 0.497 0.079 -3.432
ENSG00000176476 E005 89.7285588 0.0041346097 0.082787132 0.16391219 16 28553920 28553971 52 + 1.951 1.859 -0.307
ENSG00000176476 E006 251.9215042 0.0018194760 0.129305123 0.23320863 16 28553972 28554097 126 + 2.368 2.318 -0.166
ENSG00000176476 E007 255.8181319 0.0002096192 0.152428121 0.26497812 16 28581055 28581144 90 + 2.366 2.329 -0.124
ENSG00000176476 E008 229.3689484 0.0008215879 0.701771558 0.80078788 16 28584913 28584988 76 + 2.301 2.288 -0.045
ENSG00000176476 E009 2.9955052 0.0906278849 0.009114642 0.02657016 16 28584989 28585403 415 + 0.870 0.405 -2.061
ENSG00000176476 E010 221.2744052 0.0002571042 0.436179793 0.57828891 16 28585648 28585720 73 + 2.262 2.281 0.065
ENSG00000176476 E011 20.0499412 0.0009694602 0.366332247 0.51066986 16 28588610 28588691 82 + 1.318 1.241 -0.269
ENSG00000176476 E012 215.9799418 0.0022278602 0.574681937 0.70046432 16 28589100 28589164 65 + 2.283 2.264 -0.066
ENSG00000176476 E013 4.7219294 0.0039824673 0.005827908 0.01815801 16 28589165 28589420 256 + 0.955 0.577 -1.533
ENSG00000176476 E014 145.7680786 0.0013844430 0.875491222 0.92403632 16 28590096 28590116 21 + 2.095 2.100 0.016
ENSG00000176476 E015 252.1822508 0.0002637217 0.018437077 0.04809298 16 28590117 28590225 109 + 2.287 2.346 0.198
ENSG00000176476 E016 9.4252419 0.0258934595 0.031080984 0.07406726 16 28590226 28590295 70 + 1.141 0.858 -1.046
ENSG00000176476 E017 232.1963067 0.0010082690 0.407288082 0.55086782 16 28590296 28590384 89 + 2.278 2.301 0.075
ENSG00000176476 E018 197.0681768 0.0002684883 0.841149988 0.90089687 16 28590385 28590442 58 + 2.221 2.225 0.013
ENSG00000176476 E019 4.0138841 0.0054794869 0.221986863 0.35277867 16 28590600 28590630 31 + 0.764 0.577 -0.794
ENSG00000176476 E020 120.4847559 0.0003134508 0.748952629 0.83603984 16 28590631 28590637 7 + 2.004 2.014 0.033
ENSG00000176476 E021 142.4213998 0.0002373227 0.519569426 0.65365219 16 28590638 28590666 29 + 2.070 2.090 0.067
ENSG00000176476 E022 2.3250238 0.0065955325 0.211208623 0.33992561 16 28590667 28590772 106 + 0.624 0.412 -1.019
ENSG00000176476 E023 181.6762367 0.0002418646 0.281036859 0.42090207 16 28590773 28590845 73 + 2.167 2.198 0.103
ENSG00000176476 E024 187.7378623 0.0011237167 0.176703186 0.29695898 16 28590846 28590935 90 + 2.174 2.217 0.145
ENSG00000176476 E025 198.4725044 0.0015174462 0.512716702 0.64761570 16 28591590 28591790 201 + 2.215 2.236 0.070