ENSG00000176463

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000318445 ENSG00000176463 HEK293_OSMI2_2hA HEK293_TMG_2hB SLCO3A1 protein_coding protein_coding 0.9162524 1.7203 0.7159192 0.1197587 0.2003154 -1.253141 0.19263606 0.3219795 0.19988580 0.03357298 0.03623770 -0.6614897 0.23392083 0.1915667 0.38506667 0.19350000 6.690410e-01 7.345163e-10 FALSE TRUE
ENST00000424469 ENSG00000176463 HEK293_OSMI2_2hA HEK293_TMG_2hB SLCO3A1 protein_coding protein_coding 0.9162524 1.7203 0.7159192 0.1197587 0.2003154 -1.253141 0.21930575 0.4226750 0.13605967 0.13410725 0.07815279 -1.5667260 0.22801250 0.2369667 0.15076667 -0.08620000 7.878416e-01 7.345163e-10 FALSE TRUE
ENST00000555210 ENSG00000176463 HEK293_OSMI2_2hA HEK293_TMG_2hB SLCO3A1 protein_coding nonsense_mediated_decay 0.9162524 1.7203 0.7159192 0.1197587 0.2003154 -1.253141 0.02315200 0.0000000 0.18521602 0.00000000 0.10901258 4.2869996 0.02568750 0.0000000 0.20550000 0.20550000 2.371833e-02 7.345163e-10 TRUE FALSE
ENST00000555513 ENSG00000176463 HEK293_OSMI2_2hA HEK293_TMG_2hB SLCO3A1 protein_coding processed_transcript 0.9162524 1.7203 0.7159192 0.1197587 0.2003154 -1.253141 0.05749598 0.0000000 0.16912922 0.00000000 0.16912922 4.1629288 0.06269583 0.0000000 0.17790000 0.17790000 6.345749e-01 7.345163e-10   FALSE
ENST00000555549 ENSG00000176463 HEK293_OSMI2_2hA HEK293_TMG_2hB SLCO3A1 protein_coding processed_transcript 0.9162524 1.7203 0.7159192 0.1197587 0.2003154 -1.253141 0.29910180 0.8177959 0.00000000 0.02721747 0.00000000 -6.3712033 0.28245417 0.4796000 0.00000000 -0.47960000 7.345163e-10 7.345163e-10 FALSE TRUE
ENST00000564072 ENSG00000176463 HEK293_OSMI2_2hA HEK293_TMG_2hB SLCO3A1 protein_coding retained_intron 0.9162524 1.7203 0.7159192 0.1197587 0.2003154 -1.253141 0.05657346 0.1069537 0.02562848 0.01901478 0.02562848 -1.7148345 0.08712083 0.0615000 0.08073333 0.01923333 8.307268e-01 7.345163e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000176463 E001 0.2955422 0.031967194 0.33365814   15 91853708 91853722 15 + 0.213 0.067 -1.915
ENSG00000176463 E002 0.4772466 0.021326478 0.60248537 0.72344348 15 91853723 91853855 133 + 0.213 0.126 -0.914
ENSG00000176463 E003 3.2366662 0.016813819 0.60178904 0.72286343 15 91853856 91854024 169 + 0.619 0.525 -0.428
ENSG00000176463 E004 4.0545804 0.004234514 0.57500118 0.70073172 15 91854025 91854088 64 + 0.680 0.586 -0.409
ENSG00000176463 E005 0.0000000       15 91854121 91854301 181 +      
ENSG00000176463 E006 0.0000000       15 91854336 91854410 75 +      
ENSG00000176463 E007 0.0000000       15 91889101 91889205 105 +      
ENSG00000176463 E008 0.0000000       15 91908502 91908759 258 +      
ENSG00000176463 E009 11.1986521 0.002958490 0.41980294 0.56305848 15 91915993 91916378 386 + 1.046 0.949 -0.355
ENSG00000176463 E010 6.1809847 0.023573606 0.82745761 0.89151399 15 91916379 91916458 80 + 0.782 0.745 -0.150
ENSG00000176463 E011 0.0000000       15 91941318 91941576 259 +      
ENSG00000176463 E012 6.0055969 0.002930198 0.74015419 0.82964518 15 92094881 92094979 99 + 0.782 0.729 -0.211
ENSG00000176463 E013 0.0000000       15 92097930 92098222 293 +      
ENSG00000176463 E014 12.2420149 0.001563338 0.96111292 0.97951433 15 92104279 92104537 259 + 1.020 1.010 -0.038
ENSG00000176463 E015 3.9072297 0.004313216 0.36125642 0.50565619 15 92104538 92104542 5 + 0.462 0.622 0.751
ENSG00000176463 E016 7.7361236 0.002370281 0.37010562 0.51453291 15 92120465 92120629 165 + 0.734 0.858 0.489
ENSG00000176463 E017 6.4611873 0.003038917 0.39940193 0.54315647 15 92126061 92126183 123 + 0.864 0.743 -0.479
ENSG00000176463 E018 3.5052260 0.004844107 0.89369228 0.93599944 15 92126184 92126185 2 + 0.547 0.566 0.087
ENSG00000176463 E019 5.4552113 0.003273444 0.85244735 0.90856898 15 92126186 92126259 74 + 0.734 0.701 -0.134
ENSG00000176463 E020 9.0154306 0.002928644 0.72546938 0.81873524 15 92128351 92128489 139 + 0.864 0.906 0.158
ENSG00000176463 E021 13.9786230 0.001637798 0.43390498 0.57630206 15 92146984 92147159 176 + 1.135 1.051 -0.304
ENSG00000176463 E022 6.9173279 0.002706566 0.77273695 0.85330607 15 92150950 92150954 5 + 0.825 0.781 -0.174
ENSG00000176463 E023 9.5273970 0.002483208 0.39897852 0.54272870 15 92150955 92151014 60 + 0.993 0.887 -0.396
ENSG00000176463 E024 0.0000000       15 92151015 92151216 202 +      
ENSG00000176463 E025 0.0000000       15 92153497 92153562 66 +      
ENSG00000176463 E026 0.0000000       15 92153563 92153621 59 +      
ENSG00000176463 E027 0.0000000       15 92155193 92155269 77 +      
ENSG00000176463 E028 1.4735689 0.032308408 0.45137620 0.59233696 15 92161575 92162755 1181 + 0.213 0.368 1.079
ENSG00000176463 E029 17.6621756 0.001203144 0.54247395 0.67323022 15 92162756 92162946 191 + 1.114 1.169 0.197
ENSG00000176463 E030 8.0563436 0.062130956 0.60319520 0.72403833 15 92162947 92162998 52 + 0.781 0.880 0.386
ENSG00000176463 E031 11.1846030 0.013310345 0.18977196 0.31347420 15 92162999 92163208 210 + 0.825 1.004 0.678
ENSG00000176463 E032 13.4341194 0.001559932 0.02594276 0.06383079 15 92163209 92163546 338 + 0.825 1.093 1.004
ENSG00000176463 E033 14.2117122 0.038142031 0.05685761 0.12121744 15 92163547 92165903 2357 + 1.257 1.027 -0.823
ENSG00000176463 E034 1.2146470 0.011336104 0.65164444 0.76246679 15 92170872 92171779 908 + 0.213 0.302 0.672
ENSG00000176463 E035 0.9180607 0.013696863 1.00000000 1.00000000 15 92171780 92171847 68 + 0.213 0.223 0.089
ENSG00000176463 E036 2.7143525 0.005746056 0.12167827 0.22232537 15 92171848 92172435 588 + 0.213 0.525 1.896