ENSG00000176438

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000334258 ENSG00000176438 HEK293_OSMI2_2hA HEK293_TMG_2hB SYNE3 protein_coding protein_coding 0.7566145 1.101684 0.5434505 0.05571728 0.03504703 -1.00622 0.07958938 0.00000000 0.13530411 0.00000000 0.07033228 3.8610036 0.1418333 0.00000000 0.2353000 0.23530000 0.076309541 0.002215544 FALSE TRUE
ENST00000553340 ENSG00000176438 HEK293_OSMI2_2hA HEK293_TMG_2hB SYNE3 protein_coding protein_coding 0.7566145 1.101684 0.5434505 0.05571728 0.03504703 -1.00622 0.31687592 0.67474623 0.07966826 0.05779103 0.04138648 -2.9329001 0.3626042 0.61030000 0.1538667 -0.45643333 0.002215544 0.002215544 FALSE TRUE
ENST00000557275 ENSG00000176438 HEK293_OSMI2_2hA HEK293_TMG_2hB SYNE3 protein_coding protein_coding 0.7566145 1.101684 0.5434505 0.05571728 0.03504703 -1.00622 0.08878686 0.04723411 0.05434425 0.04723411 0.02770129 0.1689361 0.1320792 0.03956667 0.0944000 0.05483333 0.632767676 0.002215544 FALSE TRUE
ENST00000682763 ENSG00000176438 HEK293_OSMI2_2hA HEK293_TMG_2hB SYNE3 protein_coding protein_coding 0.7566145 1.101684 0.5434505 0.05571728 0.03504703 -1.00622 0.25837570 0.36968024 0.24108550 0.04497666 0.01527796 -0.5966062 0.3428333 0.34040000 0.4505667 0.11016667 0.638527419 0.002215544 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000176438 E001 97.9810622 0.0003834628 0.6364776046 0.7504980721 14 95407266 95417493 10228 - 1.977 1.961 -0.052
ENSG00000176438 E002 1.3359761 0.0097926216 0.0113221238 0.0319354185 14 95417494 95417603 110 - 0.606 0.172 -2.641
ENSG00000176438 E003 4.2250263 0.0450462266 0.5608075065 0.6887376971 14 95417604 95418026 423 - 0.762 0.666 -0.398
ENSG00000176438 E004 2.1693437 0.0068945554 0.1981398014 0.3238795402 14 95432079 95432117 39 - 0.606 0.392 -1.053
ENSG00000176438 E005 3.0486972 0.0053268513 0.0561102430 0.1198952989 14 95433260 95433409 150 - 0.762 0.470 -1.291
ENSG00000176438 E006 3.7129587 0.0044761069 0.2533482584 0.3898569393 14 95436820 95436966 147 - 0.762 0.594 -0.707
ENSG00000176438 E007 1.4350626 0.0107249703 0.6109602767 0.7301988224 14 95436967 95436981 15 - 0.437 0.346 -0.511
ENSG00000176438 E008 0.1472490 0.0457361640 0.2809755385   14 95437802 95439032 1231 - 0.157 0.000 -10.901
ENSG00000176438 E009 3.7067283 0.0930247804 0.7912679877 0.8665133672 14 95439033 95439162 130 - 0.691 0.623 -0.288
ENSG00000176438 E010 4.1108969 0.0174087578 0.6142491024 0.7327891494 14 95439612 95439784 173 - 0.728 0.646 -0.340
ENSG00000176438 E011 3.7383034 0.0099342167 0.2599952366 0.3974802571 14 95439914 95440075 162 - 0.762 0.594 -0.708
ENSG00000176438 E012 3.5848134 0.0176147263 0.0971297225 0.1860898296 14 95443155 95443289 135 - 0.793 0.537 -1.095
ENSG00000176438 E013 6.9366301 0.0031263507 0.0001600049 0.0007918405 14 95443661 95444484 824 - 0.437 0.990 2.338
ENSG00000176438 E014 9.4676618 0.0025025987 0.1174037021 0.2162461271 14 95444485 95444628 144 - 0.876 1.050 0.652
ENSG00000176438 E015 7.4361896 0.0023491077 0.0119533402 0.0334197821 14 95445909 95446091 183 - 0.651 0.979 1.297
ENSG00000176438 E016 6.8764452 0.0026348520 0.7957510908 0.8695937063 14 95449931 95450105 175 - 0.850 0.880 0.116
ENSG00000176438 E017 0.6642364 0.1338070670 0.5997557467 0.7210977289 14 95450106 95452246 2141 - 0.271 0.173 -0.829
ENSG00000176438 E018 7.2160092 0.0024105632 0.7243756585 0.8179116574 14 95452247 95452383 137 - 0.923 0.880 -0.165
ENSG00000176438 E019 18.1002716 0.0010844396 0.5419112212 0.6727794642 14 95455377 95455724 348 - 1.221 1.269 0.168
ENSG00000176438 E020 0.1472490 0.0457361640 0.2809755385   14 95455725 95456189 465 - 0.157 0.000 -10.901
ENSG00000176438 E021 9.7030135 0.0019594859 0.4730725992 0.6120772331 14 95457177 95457338 162 - 0.945 1.022 0.284
ENSG00000176438 E022 14.0599314 0.0015167634 0.3574824935 0.5018822139 14 95465931 95466240 310 - 1.089 1.173 0.301
ENSG00000176438 E023 7.8896666 0.0037380498 0.4246996818 0.5676441939 14 95467795 95467856 62 - 0.850 0.945 0.362
ENSG00000176438 E024 8.2198822 0.0021133413 0.4933954706 0.6304194491 14 95467857 95467967 111 - 0.986 0.907 -0.295
ENSG00000176438 E025 7.1053790 0.0024788470 0.9579615592 0.9776384903 14 95475678 95475835 158 - 0.876 0.880 0.017
ENSG00000176438 E026 0.0000000       14 95475836 95475836 1 -      
ENSG00000176438 E027 2.9045817 0.0057977281 0.2329083087 0.3658779269 14 95516596 95516650 55 - 0.691 0.504 -0.832