ENSG00000176390

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000324238 ENSG00000176390 HEK293_OSMI2_2hA HEK293_TMG_2hB CRLF3 protein_coding protein_coding 7.302188 2.645595 11.45672 0.4141734 0.3181307 2.110346 5.3244224 2.585985 7.483881 0.4273086 0.3244959 1.529431 0.80683750 0.9763333 0.6526667 -0.3236667 1.088937e-03 1.259637e-07 FALSE TRUE
ENST00000578692 ENSG00000176390 HEK293_OSMI2_2hA HEK293_TMG_2hB CRLF3 protein_coding nonsense_mediated_decay 7.302188 2.645595 11.45672 0.4141734 0.3181307 2.110346 1.0401321 0.000000 1.701757 0.0000000 0.3184890 7.419334 0.09046667 0.0000000 0.1490000 0.1490000 9.271629e-07 1.259637e-07 FALSE TRUE
MSTRG.14069.1 ENSG00000176390 HEK293_OSMI2_2hA HEK293_TMG_2hB CRLF3 protein_coding   7.302188 2.645595 11.45672 0.4141734 0.3181307 2.110346 0.7859331 0.000000 2.155500 0.0000000 0.4331592 7.758556 0.06384167 0.0000000 0.1882333 0.1882333 1.259637e-07 1.259637e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000176390 E001 0.1451727 0.0438295709 1.000000e+00   17 30769270 30769387 118 - 0.073 0.000 -8.578
ENSG00000176390 E002 0.2966881 0.0270948927 8.670477e-01   17 30769388 30769458 71 - 0.135 0.000 -9.577
ENSG00000176390 E003 0.0000000       17 30772363 30772437 75 -      
ENSG00000176390 E004 1.9363484 0.1502669263 2.469885e-01 3.823969e-01 17 30773407 30773497 91 - 0.502 0.200 -1.899
ENSG00000176390 E005 0.0000000       17 30774092 30774344 253 -      
ENSG00000176390 E006 134.4185876 0.0003183313 2.511110e-11 4.902331e-10 17 30782684 30783935 1252 - 2.026 2.219 0.645
ENSG00000176390 E007 60.8212601 0.0003763080 9.002045e-02 1.751690e-01 17 30783936 30784306 371 - 1.769 1.677 -0.310
ENSG00000176390 E008 40.6856982 0.0422495130 6.143536e-02 1.290484e-01 17 30784307 30784443 137 - 1.620 1.419 -0.690
ENSG00000176390 E009 0.0000000       17 30785107 30785157 51 -      
ENSG00000176390 E010 51.5451805 0.0005144394 2.965047e-04 1.365750e-03 17 30785919 30786031 113 - 1.722 1.503 -0.745
ENSG00000176390 E011 0.1515154 0.0442777527 1.000000e+00   17 30786322 30786491 170 - 0.073 0.000 -8.578
ENSG00000176390 E012 66.6329026 0.0004403803 2.933168e-01 4.343489e-01 17 30792440 30792572 133 - 1.797 1.741 -0.189
ENSG00000176390 E013 81.4650905 0.0004671082 3.477973e-01 4.920038e-01 17 30793450 30793672 223 - 1.860 1.894 0.113
ENSG00000176390 E014 67.3543373 0.0005104734 8.150786e-01 8.828470e-01 17 30796160 30796337 178 - 1.791 1.797 0.020
ENSG00000176390 E015 60.8387872 0.0003868841 2.456648e-01 3.808294e-01 17 30797311 30797398 88 - 1.762 1.698 -0.216
ENSG00000176390 E016 0.0000000       17 30801029 30801420 392 -      
ENSG00000176390 E017 40.5962794 0.0005556057 6.534638e-01 7.639333e-01 17 30803901 30803926 26 - 1.581 1.548 -0.113
ENSG00000176390 E018 68.1251732 0.0004647361 8.388702e-01 8.992890e-01 17 30803927 30804108 182 - 1.800 1.785 -0.051
ENSG00000176390 E019 0.1472490 0.0450915319 1.000000e+00   17 30809575 30809986 412 - 0.073 0.000 -8.577
ENSG00000176390 E020 37.5214027 0.0006250870 4.842110e-01 6.222289e-01 17 30824523 30824719 197 - 1.553 1.503 -0.173