ENSG00000176371

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000334141 ENSG00000176371 HEK293_OSMI2_2hA HEK293_TMG_2hB ZSCAN2 protein_coding protein_coding 12.00629 21.65944 6.67991 0.5654632 0.4719114 -1.695603 3.163221 6.725536 1.0647168 0.2440683 0.30525198 -2.647836 0.2436292 0.31036667 0.1627333 -0.14763333 0.15256952 0.04832068 FALSE TRUE
ENST00000379358 ENSG00000176371 HEK293_OSMI2_2hA HEK293_TMG_2hB ZSCAN2 protein_coding protein_coding 12.00629 21.65944 6.67991 0.5654632 0.4719114 -1.695603 4.445209 9.460852 2.7749235 0.7144405 0.44980460 -1.765857 0.3381500 0.43693333 0.4114667 -0.02546667 0.89439180 0.04832068 FALSE TRUE
ENST00000448803 ENSG00000176371 HEK293_OSMI2_2hA HEK293_TMG_2hB ZSCAN2 protein_coding protein_coding 12.00629 21.65944 6.67991 0.5654632 0.4719114 -1.695603 1.612164 3.363092 0.6916254 0.6475257 0.17132831 -2.265299 0.1265250 0.15413333 0.1044333 -0.04970000 0.58219401 0.04832068 FALSE TRUE
ENST00000546148 ENSG00000176371 HEK293_OSMI2_2hA HEK293_TMG_2hB ZSCAN2 protein_coding protein_coding 12.00629 21.65944 6.67991 0.5654632 0.4719114 -1.695603 1.640989 0.635474 1.6699871 0.6354740 0.09224115 1.380019 0.1896375 0.03026667 0.2506000 0.22033333 0.04832068 0.04832068 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000176371 E001 0.3299976 0.0274424043 6.987356e-01   15 84600986 84601004 19 + 0.000 0.140 8.865
ENSG00000176371 E002 0.3299976 0.0274424043 6.987356e-01   15 84601005 84601008 4 + 0.000 0.140 10.854
ENSG00000176371 E003 0.9619818 0.0269920978 2.069619e-01 3.348962e-01 15 84601009 84601015 7 + 0.427 0.196 -1.551
ENSG00000176371 E004 1.4392284 0.0376283966 2.344614e-01 3.677109e-01 15 84601016 84601017 2 + 0.509 0.290 -1.232
ENSG00000176371 E005 1.8089668 0.0083856730 4.285681e-01 5.713045e-01 15 84601018 84601019 2 + 0.509 0.367 -0.743
ENSG00000176371 E006 3.8675655 0.0080586852 5.193428e-01 6.534582e-01 15 84601020 84601022 3 + 0.690 0.586 -0.447
ENSG00000176371 E007 29.1621235 0.0018796189 8.753442e-01 9.239537e-01 15 84601023 84601049 27 + 1.387 1.398 0.038
ENSG00000176371 E008 69.9963539 0.0008337752 1.324668e-01 2.375113e-01 15 84601050 84601135 86 + 1.708 1.784 0.255
ENSG00000176371 E009 16.2927909 0.0011244398 5.716709e-02 1.217498e-01 15 84601136 84601188 53 + 0.996 1.195 0.718
ENSG00000176371 E010 0.1817044 0.0397834521 1.000000e+00   15 84601974 84601998 25 + 0.000 0.076 9.792
ENSG00000176371 E011 2.4636633 0.0067517565 6.253314e-01 7.414949e-01 15 84601999 84602186 188 + 0.427 0.516 0.449
ENSG00000176371 E012 1.3587887 0.0101857844 4.595332e-01 5.996458e-01 15 84602187 84602250 64 + 0.427 0.290 -0.812
ENSG00000176371 E013 93.9684322 0.0007439526 2.140006e-01 3.432543e-01 15 84603820 84603900 81 + 1.852 1.905 0.178
ENSG00000176371 E014 178.1540682 0.0002570910 6.511942e-03 1.995258e-02 15 84603901 84604200 300 + 2.107 2.188 0.272
ENSG00000176371 E015 114.9379536 0.0003025289 2.502258e-01 3.862034e-01 15 84604201 84604330 130 + 1.949 1.992 0.144
ENSG00000176371 E016 49.7845929 0.0007238471 7.943215e-01 8.685920e-01 15 84604331 84604333 3 + 1.614 1.628 0.049
ENSG00000176371 E017 27.4150514 0.0010177061 1.167318e-06 9.557652e-06 15 84606529 84606643 115 + 0.996 1.450 1.609
ENSG00000176371 E018 25.2073773 0.0008073700 1.542980e-06 1.229704e-05 15 84606644 84606889 246 + 0.944 1.413 1.676
ENSG00000176371 E019 63.5390964 0.0067198950 1.307038e-02 3.607383e-02 15 84616309 84616614 306 + 1.595 1.757 0.547
ENSG00000176371 E020 33.6485469 0.0009484071 3.775197e-06 2.763416e-05 15 84620602 84620772 171 + 1.674 1.387 -0.983
ENSG00000176371 E021 184.5480815 0.0003814259 1.452375e-11 2.945280e-10 15 84620773 84622577 1805 + 2.324 2.145 -0.599
ENSG00000176371 E022 22.8017093 0.0413968067 4.370948e-01 5.791177e-01 15 84622578 84622645 68 + 1.378 1.272 -0.369
ENSG00000176371 E023 27.0523929 0.0086635369 6.239402e-02 1.306796e-01 15 84622646 84622714 69 + 1.485 1.332 -0.526
ENSG00000176371 E024 32.2584079 0.0042032151 2.693707e-01 4.078896e-01 15 84622715 84622927 213 + 1.508 1.428 -0.273
ENSG00000176371 E025 21.5638975 0.0126656895 1.004820e-01 1.911880e-01 15 84622928 84623132 205 + 1.140 1.317 0.625
ENSG00000176371 E026 16.0250808 0.0017105343 7.183683e-01 8.134895e-01 15 84623133 84623275 143 + 1.190 1.155 -0.122
ENSG00000176371 E027 44.8507196 0.0055772682 9.710788e-01 9.859265e-01 15 84623276 84623480 205 + 1.589 1.589 -0.003
ENSG00000176371 E028 37.6977012 0.0058550732 4.443574e-01 5.859320e-01 15 84623481 84623730 250 + 1.557 1.505 -0.180
ENSG00000176371 E029 0.3686942 0.0305147995 4.363319e-01 5.784337e-01 15 84627696 84627796 101 + 0.192 0.076 -1.546