ENSG00000176273

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000371408 ENSG00000176273 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC35G1 protein_coding protein_coding 8.344481 6.126855 10.75646 0.8143907 0.3453895 0.8109721 0.4544696 0.2716306 0.5989619 0.07973315 0.07403577 1.1125481 0.05398750 0.04883333 0.055533333 0.006700000 0.839957235 0.002987261 FALSE TRUE
ENST00000427197 ENSG00000176273 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC35G1 protein_coding protein_coding 8.344481 6.126855 10.75646 0.8143907 0.3453895 0.8109721 2.3511682 1.5592121 2.7536653 0.15538520 0.03911810 0.8165426 0.25627917 0.26320000 0.256366667 -0.006833333 1.000000000 0.002987261 FALSE TRUE
ENST00000483386 ENSG00000176273 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC35G1 protein_coding nonsense_mediated_decay 8.344481 6.126855 10.75646 0.8143907 0.3453895 0.8109721 1.6075789 1.0037565 2.1457883 0.11315616 0.20588348 1.0885043 0.19851250 0.16516667 0.198700000 0.033533333 0.554612858 0.002987261   FALSE
ENST00000605679 ENSG00000176273 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC35G1 protein_coding nonsense_mediated_decay 8.344481 6.126855 10.75646 0.8143907 0.3453895 0.8109721 0.8783913 1.2883450 0.6756627 0.14590547 0.18413215 -0.9211028 0.13321667 0.21163333 0.064066667 -0.147566667 0.002987261 0.002987261   FALSE
MSTRG.4402.3 ENSG00000176273 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC35G1 protein_coding   8.344481 6.126855 10.75646 0.8143907 0.3453895 0.8109721 0.3170583 0.5445142 0.0000000 0.32674707 0.00000000 -5.7931524 0.05939583 0.08903333 0.000000000 -0.089033333 0.083618979 0.002987261   FALSE
MSTRG.4402.4 ENSG00000176273 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC35G1 protein_coding   8.344481 6.126855 10.75646 0.8143907 0.3453895 0.8109721 2.1986082 0.6862032 4.2897574 0.57160876 0.22229708 2.6266750 0.22084167 0.09270000 0.398300000 0.305600000 0.097945135 0.002987261 FALSE TRUE
MSTRG.4402.6 ENSG00000176273 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC35G1 protein_coding   8.344481 6.126855 10.75646 0.8143907 0.3453895 0.8109721 0.4615492 0.6082194 0.1005130 0.03243138 0.10051298 -2.4839031 0.06799167 0.10206667 0.009266667 -0.092800000 0.031449020 0.002987261   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000176273 E001 1.6639845 0.0094133943 8.513519e-01 9.078305e-01 10 93893973 93893977 5 + 0.427 0.368 -0.329
ENSG00000176273 E002 2.3240814 0.0569226458 7.792345e-01 8.580230e-01 10 93893978 93893987 10 + 0.499 0.510 0.056
ENSG00000176273 E003 2.4713304 0.0302307111 9.321016e-01 9.612360e-01 10 93893988 93893990 3 + 0.530 0.509 -0.102
ENSG00000176273 E004 6.4570965 0.0409457659 2.380316e-01 3.718602e-01 10 93893991 93894000 10 + 0.937 0.701 -0.927
ENSG00000176273 E005 7.5567623 0.0475060434 5.657953e-01 6.928421e-01 10 93894001 93894001 1 + 0.971 0.832 -0.530
ENSG00000176273 E006 13.5222267 0.0569365075 5.669705e-01 6.938597e-01 10 93894002 93894021 20 + 1.200 1.055 -0.518
ENSG00000176273 E007 35.0714984 0.0177015890 7.784629e-01 8.574580e-01 10 93894022 93894160 139 + 1.558 1.525 -0.114
ENSG00000176273 E008 16.5165954 0.0012350520 5.708783e-01 6.973011e-01 10 93894161 93894211 51 + 1.231 1.240 0.034
ENSG00000176273 E009 15.4737029 0.0012844528 9.782461e-02 1.871959e-01 10 93898571 93898573 3 + 1.272 1.082 -0.675
ENSG00000176273 E010 44.6803698 0.0009278904 2.581161e-06 1.960757e-05 10 93898574 93898751 178 + 1.752 1.440 -1.061
ENSG00000176273 E011 394.0358952 0.0130673656 8.735562e-03 2.562479e-02 10 93900752 93903824 3073 + 2.631 2.513 -0.392
ENSG00000176273 E012 24.1473681 0.0091363358 2.166482e-08 2.509683e-07 10 93906252 93906385 134 + 1.186 1.595 1.421
ENSG00000176273 E013 36.1188681 0.0006415671 9.742307e-01 9.879300e-01 10 93907099 93908027 929 + 1.578 1.540 -0.128
ENSG00000176273 E014 85.8862919 0.0042176741 5.946526e-02 1.257158e-01 10 93908028 93909830 1803 + 1.914 1.957 0.144
ENSG00000176273 E015 9.8654016 0.0018555302 7.080239e-09 8.974526e-08 10 93912667 93912799 133 + 0.724 1.292 2.112
ENSG00000176273 E016 14.3049441 0.0086290529 1.636488e-14 5.231653e-13 10 93954009 93954168 160 + 0.743 1.479 2.682
ENSG00000176273 E017 4.1943423 0.0039250413 4.151805e-04 1.832546e-03 10 93954169 93954256 88 + 0.464 0.931 1.978
ENSG00000176273 E018 0.6685028 0.0176628980 4.865028e-01 6.242423e-01 10 93955974 93956062 89 + 0.170 0.276 0.891