ENSG00000176261

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000436661 ENSG00000176261 HEK293_OSMI2_2hA HEK293_TMG_2hB ZBTB8OS protein_coding protein_coding 29.31422 30.38618 36.73083 2.190926 2.014966 0.2734939 9.438935 10.381613 12.459046 0.6041631 1.2173721 0.2629315 0.3157958 0.3423000 0.33800000 -0.004300000 9.809605e-01 2.817582e-06 FALSE TRUE
ENST00000468695 ENSG00000176261 HEK293_OSMI2_2hA HEK293_TMG_2hB ZBTB8OS protein_coding protein_coding 29.31422 30.38618 36.73083 2.190926 2.014966 0.2734939 4.803354 4.952753 6.133318 0.7961764 0.1492363 0.3078775 0.1622083 0.1610333 0.16846667 0.007433333 9.344913e-01 2.817582e-06 FALSE TRUE
MSTRG.772.2 ENSG00000176261 HEK293_OSMI2_2hA HEK293_TMG_2hB ZBTB8OS protein_coding   29.31422 30.38618 36.73083 2.190926 2.014966 0.2734939 2.500020 3.618312 2.254084 0.2584680 0.4996989 -0.6803710 0.0911250 0.1214000 0.06040000 -0.061000000 7.607779e-02 2.817582e-06   FALSE
MSTRG.772.9 ENSG00000176261 HEK293_OSMI2_2hA HEK293_TMG_2hB ZBTB8OS protein_coding   29.31422 30.38618 36.73083 2.190926 2.014966 0.2734939 1.107230 0.000000 1.897111 0.0000000 0.6760280 7.5752448 0.0349250 0.0000000 0.05333333 0.053333333 2.817582e-06 2.817582e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000176261 E001 2.797991 0.0053925298 4.456121e-01 5.871666e-01 1 32600172 32600309 138 - 0.512 0.633 0.549
ENSG00000176261 E002 1.258555 0.0121939925 4.728254e-01 6.118660e-01 1 32600310 32600350 41 - 0.293 0.422 0.769
ENSG00000176261 E003 33.089635 0.0015510080 5.465595e-11 1.008121e-09 1 32609052 32609196 145 - 1.249 1.682 1.493
ENSG00000176261 E004 32.458690 0.0006454431 4.664166e-08 5.062230e-07 1 32609197 32609327 131 - 1.307 1.654 1.193
ENSG00000176261 E005 21.914377 0.0067935672 4.765840e-05 2.699095e-04 1 32610097 32610148 52 - 1.142 1.482 1.189
ENSG00000176261 E006 26.662084 0.0135170953 1.170364e-02 3.282776e-02 1 32612043 32612298 256 - 1.314 1.523 0.720
ENSG00000176261 E007 4.729344 0.0075518638 7.630788e-01 8.465383e-01 1 32619560 32619656 97 - 0.789 0.748 -0.161
ENSG00000176261 E008 88.086077 0.0024953671 6.852561e-01 7.880471e-01 1 32620820 32621310 491 - 1.964 1.949 -0.050
ENSG00000176261 E009 55.816484 0.0004489859 1.941473e-01 3.189799e-01 1 32621311 32621504 194 - 1.728 1.789 0.208
ENSG00000176261 E010 44.467718 0.0005128785 9.128029e-01 9.487504e-01 1 32621505 32621603 99 - 1.660 1.667 0.023
ENSG00000176261 E011 32.528611 0.0006482967 3.074188e-01 4.496466e-01 1 32621604 32621644 41 - 1.561 1.500 -0.208
ENSG00000176261 E012 38.090240 0.0006196452 7.692598e-01 8.509466e-01 1 32621645 32621757 113 - 1.608 1.593 -0.052
ENSG00000176261 E013 25.770190 0.0011262493 1.230290e-01 2.242764e-01 1 32621758 32621829 72 - 1.371 1.477 0.364
ENSG00000176261 E014 35.432388 0.0007972489 9.854997e-01 9.949477e-01 1 32621830 32621840 11 - 1.568 1.570 0.007
ENSG00000176261 E015 52.469635 0.0004271066 9.329262e-01 9.617355e-01 1 32621841 32621857 17 - 1.735 1.732 -0.011
ENSG00000176261 E016 214.972849 0.0001992999 1.676797e-01 2.851742e-01 1 32621858 32621948 91 - 2.320 2.352 0.109
ENSG00000176261 E017 191.523420 0.0002431744 3.148144e-01 4.575634e-01 1 32627508 32627544 37 - 2.275 2.300 0.086
ENSG00000176261 E018 3.073966 0.0056356377 7.864350e-01 8.632367e-01 1 32627572 32627776 205 - 0.590 0.633 0.185
ENSG00000176261 E019 13.151370 0.0508836825 5.138264e-01 6.486022e-01 1 32627777 32627865 89 - 1.112 1.184 0.259
ENSG00000176261 E020 1.435993 0.0099031963 3.080845e-01 4.503316e-01 1 32631825 32631826 2 - 0.293 0.473 1.032
ENSG00000176261 E021 96.904465 0.0002987851 3.243136e-01 4.676636e-01 1 32631827 32631879 53 - 2.013 1.978 -0.115
ENSG00000176261 E022 1.622066 0.0086268321 9.709868e-01 9.858806e-01 1 32631880 32632058 179 - 0.416 0.423 0.034
ENSG00000176261 E023 4.490106 0.0778978443 6.462405e-02 1.344155e-01 1 32632208 32632345 138 - 0.889 0.560 -1.361
ENSG00000176261 E024 1.915407 0.1468209572 1.094895e-01 2.048192e-01 1 32633262 32633354 93 - 0.624 0.294 -1.732
ENSG00000176261 E025 198.087842 0.0002362411 3.661987e-01 5.105438e-01 1 32633645 32633727 83 - 2.291 2.314 0.075
ENSG00000176261 E026 332.819226 0.0001562428 2.391960e-02 5.963830e-02 1 32633951 32634072 122 - 2.549 2.508 -0.137
ENSG00000176261 E027 64.700333 0.0003919447 8.839391e-02 1.726645e-01 1 32634073 32634110 38 - 1.860 1.787 -0.245
ENSG00000176261 E028 4.410135 0.0037257052 3.597667e-04 1.617951e-03 1 32634111 32634357 247 - 0.940 0.423 -2.229
ENSG00000176261 E029 6.726062 0.0449737110 2.528428e-02 6.245802e-02 1 32634358 32634701 344 - 1.041 0.693 -1.344
ENSG00000176261 E030 32.887827 0.0072442867 8.199206e-01 8.863322e-01 1 32634702 32634767 66 - 1.541 1.518 -0.081
ENSG00000176261 E031 204.571949 0.0002335912 4.373479e-02 9.790521e-02 1 32634768 32634792 25 - 2.344 2.296 -0.159
ENSG00000176261 E032 13.216538 0.0063243708 6.371639e-02 1.328880e-01 1 32650402 32650428 27 - 1.249 1.073 -0.628
ENSG00000176261 E033 28.407419 0.0022893624 5.967454e-01 7.186414e-01 1 32650429 32650432 4 - 1.495 1.461 -0.115
ENSG00000176261 E034 333.437107 0.0002290795 4.593493e-02 1.019164e-01 1 32650433 32650903 471 - 2.548 2.510 -0.125