ENSG00000176248

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000323927 ENSG00000176248 HEK293_OSMI2_2hA HEK293_TMG_2hB ANAPC2 protein_coding protein_coding 57.41513 74.42562 42.71562 5.190751 1.057348 -0.8008916 32.938193 55.253076 21.327554 3.2935493 0.5376577 -1.3729211 0.56088333 0.74350000 0.4994667 -0.24403333 3.182130e-19 3.18213e-19 FALSE TRUE
ENST00000483432 ENSG00000176248 HEK293_OSMI2_2hA HEK293_TMG_2hB ANAPC2 protein_coding processed_transcript 57.41513 74.42562 42.71562 5.190751 1.057348 -0.8008916 4.445313 4.606663 3.411530 0.2683328 0.2321538 -0.4322088 0.07614583 0.06240000 0.0802000 0.01780000 4.025209e-01 3.18213e-19 FALSE TRUE
ENST00000493730 ENSG00000176248 HEK293_OSMI2_2hA HEK293_TMG_2hB ANAPC2 protein_coding retained_intron 57.41513 74.42562 42.71562 5.190751 1.057348 -0.8008916 4.238061 2.090327 4.558441 1.1104031 0.5156498 1.1210877 0.07842917 0.02786667 0.1062667 0.07840000 4.140236e-01 3.18213e-19   FALSE
ENST00000495611 ENSG00000176248 HEK293_OSMI2_2hA HEK293_TMG_2hB ANAPC2 protein_coding retained_intron 57.41513 74.42562 42.71562 5.190751 1.057348 -0.8008916 5.982024 3.760691 5.520161 0.8621529 0.5675658 0.5524923 0.10909167 0.04956667 0.1296000 0.08003333 6.625882e-04 3.18213e-19 FALSE FALSE
ENST00000618649 ENSG00000176248 HEK293_OSMI2_2hA HEK293_TMG_2hB ANAPC2 protein_coding retained_intron 57.41513 74.42562 42.71562 5.190751 1.057348 -0.8008916 5.626563 3.592728 6.066140 0.4835391 0.5978219 0.7540652 0.10613750 0.04790000 0.1415667 0.09366667 2.440023e-09 3.18213e-19 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000176248 E001 298.213330 0.0007153929 2.301792e-09 3.191829e-08 9 137174784 137175154 371 - 2.273 2.437 0.546
ENSG00000176248 E002 263.077561 0.0002626633 4.846705e-08 5.242328e-07 9 137175237 137175273 37 - 2.234 2.379 0.482
ENSG00000176248 E003 182.679612 0.0009674103 8.625525e-05 4.574564e-04 9 137175274 137175274 1 - 2.087 2.220 0.444
ENSG00000176248 E004 352.079285 0.0028249251 6.778739e-04 2.818108e-03 9 137175275 137175331 57 - 2.386 2.500 0.382
ENSG00000176248 E005 458.446653 0.0015449148 9.943979e-06 6.613041e-05 9 137175332 137175468 137 - 2.497 2.615 0.392
ENSG00000176248 E006 217.378297 0.0003124738 2.352111e-03 8.314370e-03 9 137175469 137175472 4 - 2.199 2.284 0.284
ENSG00000176248 E007 45.317369 0.0004911894 2.997943e-04 1.378824e-03 9 137175473 137175707 235 - 1.740 1.535 -0.697
ENSG00000176248 E008 491.192259 0.0025206097 9.572038e-03 2.771206e-02 9 137175708 137175837 130 - 2.558 2.636 0.259
ENSG00000176248 E009 59.855835 0.0045646300 2.353428e-02 5.885108e-02 9 137175838 137176002 165 - 1.807 1.672 -0.454
ENSG00000176248 E010 215.363815 0.0016406326 1.958052e-19 1.174627e-17 9 137176003 137177072 1070 - 2.459 2.174 -0.953
ENSG00000176248 E011 614.189607 0.0005185452 2.038731e-01 3.310405e-01 9 137180181 137180384 204 - 2.698 2.720 0.072
ENSG00000176248 E012 326.786925 0.0001470004 4.691664e-01 6.084611e-01 9 137180452 137180527 76 - 2.431 2.443 0.041
ENSG00000176248 E013 485.627013 0.0001667914 9.190571e-02 1.780784e-01 9 137180788 137180929 142 - 2.591 2.619 0.093
ENSG00000176248 E014 238.718939 0.0014599389 5.743212e-01 7.001507e-01 9 137181681 137181681 1 - 2.323 2.302 -0.071
ENSG00000176248 E015 490.379575 0.0008906828 7.410162e-01 8.303216e-01 9 137181682 137181814 133 - 2.626 2.615 -0.035
ENSG00000176248 E016 309.066489 0.0001792182 2.583610e-01 3.956063e-01 9 137181815 137181862 48 - 2.440 2.409 -0.101
ENSG00000176248 E017 446.403874 0.0006970990 5.629300e-01 6.904710e-01 9 137183125 137183242 118 - 2.587 2.572 -0.053
ENSG00000176248 E018 8.968189 0.0023793650 1.540994e-07 1.509575e-06 9 137183243 137183614 372 - 1.283 0.713 -2.125
ENSG00000176248 E019 417.407415 0.0002103652 4.679064e-01 6.073425e-01 9 137183672 137183791 120 - 2.559 2.540 -0.062
ENSG00000176248 E020 383.189325 0.0027414087 5.142741e-01 6.489979e-01 9 137184913 137185087 175 - 2.526 2.505 -0.070
ENSG00000176248 E021 301.446769 0.0016737923 9.424051e-01 9.678259e-01 9 137186224 137186356 133 - 2.404 2.405 0.002
ENSG00000176248 E022 31.850706 0.0006722978 2.312301e-18 1.217505e-16 9 137186357 137186509 153 - 1.784 1.237 -1.880
ENSG00000176248 E023 114.243586 0.0038589042 2.921721e-34 6.816641e-32 9 137186673 137187480 808 - 2.331 1.785 -1.832
ENSG00000176248 E024 855.178995 0.0017192873 5.460700e-02 1.173064e-01 9 137187481 137188103 623 - 2.892 2.848 -0.146
ENSG00000176248 E025 222.190336 0.0051031598 1.899552e-01 3.137030e-01 9 137188416 137188560 145 - 2.315 2.260 -0.186