ENSG00000176155

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000327026 ENSG00000176155 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC57 protein_coding processed_transcript 15.43456 17.13883 10.47341 1.186066 0.2541348 -0.7100023 4.0429676 3.708033 3.2101169 0.3163159 0.08884812 -0.2074264 0.27494583 0.2177667 0.30656667 0.08880000 6.051930e-02 6.865556e-28 FALSE TRUE
ENST00000392346 ENSG00000176155 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC57 protein_coding retained_intron 15.43456 17.13883 10.47341 1.186066 0.2541348 -0.7100023 1.5901920 2.070816 0.7613882 0.3213545 0.15026357 -1.4316202 0.09682083 0.1197333 0.07270000 -0.04703333 1.937940e-01 6.865556e-28 FALSE TRUE
ENST00000581625 ENSG00000176155 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC57 protein_coding nonsense_mediated_decay 15.43456 17.13883 10.47341 1.186066 0.2541348 -0.7100023 0.3580540 0.000000 0.5398821 0.0000000 0.03359210 5.7810503 0.02772083 0.0000000 0.05176667 0.05176667 4.991648e-13 6.865556e-28 FALSE FALSE
ENST00000584717 ENSG00000176155 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC57 protein_coding processed_transcript 15.43456 17.13883 10.47341 1.186066 0.2541348 -0.7100023 1.1135468 1.494533 0.1944006 0.6933754 0.11727123 -2.8798438 0.05965417 0.0882000 0.01813333 -0.07006667 2.739223e-01 6.865556e-28 FALSE FALSE
ENST00000694881 ENSG00000176155 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC57 protein_coding protein_coding 15.43456 17.13883 10.47341 1.186066 0.2541348 -0.7100023 1.4416264 2.360760 0.0000000 0.1721470 0.00000000 -7.8892056 0.08464583 0.1377000 0.00000000 -0.13770000 6.865556e-28 6.865556e-28 FALSE TRUE
MSTRG.15332.10 ENSG00000176155 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC57 protein_coding   15.43456 17.13883 10.47341 1.186066 0.2541348 -0.7100023 0.5979063 0.000000 1.4049218 0.0000000 0.33080916 7.1445785 0.05082083 0.0000000 0.13583333 0.13583333 7.397533e-13 6.865556e-28 FALSE TRUE
MSTRG.15332.5 ENSG00000176155 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC57 protein_coding   15.43456 17.13883 10.47341 1.186066 0.2541348 -0.7100023 2.0729987 2.049553 1.5737720 0.5083448 0.17194680 -0.3789664 0.13824167 0.1186000 0.14980000 0.03120000 6.436632e-01 6.865556e-28 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000176155 E001 5.9963056 0.0099681300 2.172962e-04 1.037950e-03 17 82099776 82101377 1602 - 1.067 0.601 -1.837
ENSG00000176155 E002 1.9843153 0.0072378572 8.604044e-01 9.139499e-01 17 82101378 82101459 82 - 0.433 0.475 0.217
ENSG00000176155 E003 2.3927755 0.0061109047 2.488815e-01 3.846173e-01 17 82101460 82101469 10 - 0.358 0.572 1.091
ENSG00000176155 E004 6.6457996 0.0107205073 3.054030e-01 4.475029e-01 17 82101470 82101495 26 - 0.756 0.912 0.611
ENSG00000176155 E005 14.7157565 0.0181595715 7.977673e-04 3.251461e-03 17 82101496 82101522 27 - 0.844 1.277 1.584
ENSG00000176155 E006 23.3655977 0.0386980580 5.010956e-04 2.164065e-03 17 82101523 82101558 36 - 0.980 1.472 1.745
ENSG00000176155 E007 42.3359581 0.0261898725 5.560301e-06 3.916647e-05 17 82101559 82101660 102 - 1.214 1.723 1.753
ENSG00000176155 E008 28.5804229 0.0113265903 5.694480e-06 4.000898e-05 17 82101661 82101673 13 - 1.098 1.550 1.581
ENSG00000176155 E009 34.9996254 0.0082126958 1.498900e-06 1.198912e-05 17 82101674 82101689 16 - 1.203 1.629 1.475
ENSG00000176155 E010 52.4903727 0.0210049945 2.641697e-04 1.233636e-03 17 82101690 82101751 62 - 1.425 1.792 1.251
ENSG00000176155 E011 92.0357226 0.0212327705 1.291254e-02 3.570894e-02 17 82101752 82101866 115 - 1.765 2.006 0.810
ENSG00000176155 E012 6.0846875 0.0569718529 7.990880e-03 2.375521e-02 17 82104795 82105113 319 - 0.432 0.945 2.194
ENSG00000176155 E013 5.8495269 0.0152187095 5.748886e-02 1.223223e-01 17 82106270 82106587 318 - 0.601 0.898 1.211
ENSG00000176155 E014 2.0250117 0.0079960544 2.860262e-02 6.921661e-02 17 82107402 82107621 220 - 0.154 0.571 2.675
ENSG00000176155 E015 5.5070579 0.0070732987 9.566243e-02 1.838881e-01 17 82108768 82108954 187 - 0.601 0.858 1.054
ENSG00000176155 E016 22.7652651 0.0174335521 2.557158e-03 8.933827e-03 17 82111986 82113765 1780 - 1.098 1.427 1.157
ENSG00000176155 E017 49.6824791 0.0114812076 6.021703e-02 1.269763e-01 17 82127692 82127704 13 - 1.557 1.724 0.570
ENSG00000176155 E018 119.4370078 0.0053751825 7.350809e-04 3.025591e-03 17 82127705 82127908 204 - 1.914 2.106 0.643
ENSG00000176155 E019 54.1851469 0.0145952570 4.522561e-03 1.460671e-02 17 82128493 82128528 36 - 1.524 1.780 0.870
ENSG00000176155 E020 65.3542002 0.0186358492 1.814621e-02 4.744597e-02 17 82128529 82128597 69 - 1.631 1.851 0.745
ENSG00000176155 E021 65.0630691 0.0006492227 1.492635e-03 5.612178e-03 17 82134073 82134194 122 - 1.661 1.834 0.587
ENSG00000176155 E022 1.4767911 0.0097032402 3.848928e-01 5.290463e-01 17 82134195 82134343 149 - 0.268 0.437 1.023
ENSG00000176155 E023 4.1338731 0.0039118258 4.053534e-02 9.200265e-02 17 82135112 82135394 283 - 0.433 0.775 1.539
ENSG00000176155 E024 95.3649364 0.0032712152 3.911271e-04 1.740489e-03 17 82151560 82151773 214 - 1.810 2.003 0.649
ENSG00000176155 E025 80.2683020 0.0018899738 3.166088e-04 1.447128e-03 17 82151774 82152299 526 - 1.735 1.927 0.647
ENSG00000176155 E026 298.6493481 0.0010059820 1.347326e-03 5.134098e-03 17 82153610 82155916 2307 - 2.483 2.425 -0.194
ENSG00000176155 E027 11.9146490 0.0222272060 2.917717e-01 4.326866e-01 17 82155917 82155919 3 - 0.979 1.122 0.519
ENSG00000176155 E028 52.2361589 0.0113657917 7.022795e-01 8.011269e-01 17 82155920 82156283 364 - 1.700 1.690 -0.033
ENSG00000176155 E029 56.5445363 0.0011872763 5.856117e-02 1.241647e-01 17 82156284 82156736 453 - 1.777 1.701 -0.260
ENSG00000176155 E030 93.0705981 0.0059279582 6.792135e-06 4.692912e-05 17 82156737 82157447 711 - 2.076 1.864 -0.715
ENSG00000176155 E031 37.6703243 0.0136347554 3.561735e-02 8.284144e-02 17 82157448 82157747 300 - 1.653 1.502 -0.516
ENSG00000176155 E032 60.4845763 0.0039902643 9.052268e-01 9.436745e-01 17 82157748 82157948 201 - 1.749 1.759 0.035
ENSG00000176155 E033 25.7385345 0.0008029578 1.935744e-01 3.182738e-01 17 82163200 82163216 17 - 1.445 1.373 -0.252
ENSG00000176155 E034 50.1781264 0.0004669418 3.229740e-01 4.663292e-01 17 82163217 82163357 141 - 1.700 1.667 -0.112
ENSG00000176155 E035 2.9193159 0.0098054468 6.579139e-01 7.671878e-01 17 82163358 82163390 33 - 0.601 0.542 -0.266
ENSG00000176155 E036 63.6191144 0.0008740269 1.717325e-01 2.904705e-01 17 82171701 82171853 153 - 1.807 1.761 -0.157
ENSG00000176155 E037 62.3123808 0.0029941857 8.890664e-03 2.600688e-02 17 82172638 82172860 223 - 1.841 1.724 -0.395
ENSG00000176155 E038 4.1855777 0.0213852111 4.951071e-03 1.579466e-02 17 82175566 82175664 99 - 0.917 0.510 -1.699
ENSG00000176155 E039 39.7900076 0.0005696378 6.179605e-03 1.908679e-02 17 82178474 82178605 132 - 1.665 1.528 -0.466
ENSG00000176155 E040 23.7381850 0.0082526844 8.401394e-01 9.001690e-01 17 82179027 82179189 163 - 1.366 1.364 -0.006
ENSG00000176155 E041 0.2214452 0.0368022393 8.290347e-01   17 82181558 82181624 67 - 0.000 0.096 10.238
ENSG00000176155 E042 54.0758879 0.0039941156 2.408677e-03 8.488192e-03 17 82183774 82183932 159 - 1.807 1.654 -0.521
ENSG00000176155 E043 1.8874319 0.0660205712 1.606355e-01 2.759564e-01 17 82184958 82185172 215 - 0.601 0.349 -1.277
ENSG00000176155 E044 0.0000000       17 82188190 82188218 29 -      
ENSG00000176155 E045 25.8251409 0.0048038074 5.089043e-02 1.107529e-01 17 82188219 82188223 5 - 1.477 1.346 -0.455
ENSG00000176155 E046 40.4246169 0.0018911735 2.481582e-02 6.149647e-02 17 82188224 82188349 126 - 1.657 1.542 -0.393
ENSG00000176155 E047 30.2443876 0.0014502855 2.780595e-01 4.176846e-01 17 82188350 82188419 70 - 1.496 1.441 -0.189
ENSG00000176155 E048 3.1085129 0.0048828334 2.199996e-03 7.841784e-03 17 82190434 82190523 90 - 0.844 0.396 -2.006
ENSG00000176155 E049 30.6998674 0.0196413737 6.593996e-02 1.365976e-01 17 82193756 82193830 75 - 1.561 1.412 -0.513
ENSG00000176155 E050 26.4222395 0.0066745305 1.114866e-05 7.327253e-05 17 82193831 82193981 151 - 1.591 1.272 -1.100
ENSG00000176155 E051 44.2018136 0.0038821715 1.319591e-04 6.674300e-04 17 82193982 82194139 158 - 1.752 1.540 -0.721
ENSG00000176155 E052 0.3729606 0.0278663866 6.697127e-01 7.763975e-01 17 82194140 82194255 116 - 0.154 0.096 -0.780
ENSG00000176155 E053 42.2836355 0.0011971583 6.924584e-04 2.871454e-03 17 82195263 82195364 102 - 1.711 1.538 -0.586
ENSG00000176155 E054 1.0531193 0.3668050447 7.079414e-02 1.446711e-01 17 82195489 82195611 123 - 0.554 0.095 -3.407
ENSG00000176155 E055 0.2214452 0.0368022393 8.290347e-01   17 82196706 82196798 93 - 0.000 0.096 10.238
ENSG00000176155 E056 0.8232405 0.1522580511 7.477349e-02 1.511643e-01 17 82196892 82197096 205 - 0.433 0.097 -2.772
ENSG00000176155 E057 22.3137709 0.0032373245 3.288440e-02 7.757060e-02 17 82198314 82198336 23 - 1.425 1.277 -0.515
ENSG00000176155 E058 37.1398387 0.0015214567 7.397887e-03 2.225361e-02 17 82198337 82198422 86 - 1.636 1.493 -0.490
ENSG00000176155 E059 48.3376871 0.0004918384 4.748682e-05 2.690262e-04 17 82201538 82201758 221 - 1.777 1.588 -0.642
ENSG00000176155 E060 47.2539026 0.0033417402 3.331985e-04 1.513088e-03 17 82201759 82201952 194 - 1.765 1.576 -0.641
ENSG00000176155 E061 1.1468953 0.0112857291 2.571040e-01 3.941444e-01 17 82207563 82207730 168 - 0.433 0.242 -1.197
ENSG00000176155 E062 2.3366520 0.0072600028 2.838747e-01 4.240727e-01 17 82207731 82207846 116 - 0.601 0.437 -0.782
ENSG00000176155 E063 2.5034042 0.0062771147 1.873460e-01 3.104034e-01 17 82207847 82207859 13 - 0.358 0.599 1.216
ENSG00000176155 E064 6.4881460 0.0026488227 5.066610e-01 6.423135e-01 17 82207860 82208048 189 - 0.894 0.826 -0.259
ENSG00000176155 E065 0.1451727 0.0427309109 2.782204e-01   17 82212780 82212784 5 - 0.154 0.000 -11.924
ENSG00000176155 E066 17.3320821 0.0025664160 1.113717e-02 3.149531e-02 17 82212785 82212900 116 - 1.349 1.152 -0.696