ENSG00000176142

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000473684 ENSG00000176142 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM39A protein_coding nonsense_mediated_decay 31.95937 21.10362 36.83772 2.084121 0.8056683 0.8034011 1.8721547 1.077068 2.4624512 0.2463271 0.20798963 1.1854997 0.05498750 0.05316667 0.066666667 0.01350000 0.704356983 0.002824157   FALSE
MSTRG.23488.10 ENSG00000176142 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM39A protein_coding   31.95937 21.10362 36.83772 2.084121 0.8056683 0.8034011 2.9895364 2.618845 2.0961771 0.5370961 0.50193154 -0.3198024 0.09288750 0.12776667 0.056700000 -0.07106667 0.169901692 0.002824157 FALSE TRUE
MSTRG.23488.12 ENSG00000176142 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM39A protein_coding   31.95937 21.10362 36.83772 2.084121 0.8056683 0.8034011 0.6272892 0.000000 2.2717084 0.0000000 1.15155859 7.8339706 0.01834583 0.00000000 0.062200000 0.06220000 0.240320140 0.002824157 FALSE TRUE
MSTRG.23488.5 ENSG00000176142 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM39A protein_coding   31.95937 21.10362 36.83772 2.084121 0.8056683 0.8034011 5.7729939 3.423395 7.1763238 1.0680544 0.07370447 1.0656180 0.17410833 0.16006667 0.195100000 0.03503333 0.703152348 0.002824157 FALSE TRUE
MSTRG.23488.7 ENSG00000176142 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM39A protein_coding   31.95937 21.10362 36.83772 2.084121 0.8056683 0.8034011 2.0552370 3.245377 0.2895034 0.6128306 0.17405633 -3.4421804 0.07807083 0.15103333 0.008066667 -0.14296667 0.002824157 0.002824157 FALSE TRUE
MSTRG.23488.8 ENSG00000176142 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM39A protein_coding   31.95937 21.10362 36.83772 2.084121 0.8056683 0.8034011 5.6923664 4.222753 6.1191284 0.6474906 0.22516250 0.5340856 0.18800833 0.20580000 0.166033333 -0.03976667 0.752626543 0.002824157 FALSE TRUE
MSTRG.23488.9 ENSG00000176142 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM39A protein_coding   31.95937 21.10362 36.83772 2.084121 0.8056683 0.8034011 6.8853781 3.855852 9.2457050 0.6034325 0.15495103 1.2595564 0.21830000 0.18073333 0.251166667 0.07043333 0.029054218 0.002824157 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000176142 E001 4.579893 0.0128657072 9.564415e-01 9.767161e-01 3 119428949 119429499 551 - 0.759 0.771 0.050
ENSG00000176142 E002 127.619139 0.0065462989 3.703390e-01 5.147818e-01 3 119429500 119430867 1368 - 2.133 2.092 -0.137
ENSG00000176142 E003 192.538661 0.0103360053 3.226030e-02 7.635418e-02 3 119430868 119431562 695 - 2.339 2.226 -0.377
ENSG00000176142 E004 85.519558 0.0109999114 5.028004e-02 1.096613e-01 3 119431563 119431753 191 - 1.993 1.876 -0.393
ENSG00000176142 E005 75.797139 0.0147116808 1.585181e-01 2.731411e-01 3 119431754 119431877 124 - 1.834 1.948 0.384
ENSG00000176142 E006 42.709868 0.0161229967 5.635968e-05 3.134537e-04 3 119431878 119431929 52 - 1.457 1.797 1.158
ENSG00000176142 E007 239.959276 0.0004789465 6.873365e-07 5.911555e-06 3 119431930 119432214 285 - 2.327 2.444 0.389
ENSG00000176142 E008 155.198172 0.0005107082 1.364226e-07 1.350517e-06 3 119434762 119434882 121 - 2.119 2.271 0.510
ENSG00000176142 E009 12.027372 0.0047766241 8.979526e-02 1.748152e-01 3 119435755 119435935 181 - 1.182 1.006 -0.640
ENSG00000176142 E010 6.655791 0.0353288151 1.801107e-01 3.013063e-01 3 119436589 119436790 202 - 0.972 0.771 -0.771
ENSG00000176142 E011 198.593403 0.0022093514 3.573493e-03 1.193729e-02 3 119436791 119436943 153 - 2.259 2.347 0.295
ENSG00000176142 E012 126.904403 0.0002402994 7.017069e-01 8.007630e-01 3 119436944 119436978 35 - 2.119 2.106 -0.042
ENSG00000176142 E013 231.811398 0.0001825458 1.985689e-01 3.244010e-01 3 119437755 119437933 179 - 2.358 2.387 0.095
ENSG00000176142 E014 240.969497 0.0001794743 6.522126e-01 7.629344e-01 3 119437934 119438103 170 - 2.394 2.382 -0.038
ENSG00000176142 E015 2.631165 0.0056787050 5.575817e-01 6.859718e-01 3 119446642 119447017 376 - 0.609 0.515 -0.430
ENSG00000176142 E016 110.162204 0.0002648405 8.651634e-01 9.171275e-01 3 119447018 119447018 1 - 2.047 2.052 0.015
ENSG00000176142 E017 239.571526 0.0001618508 9.175946e-01 9.519236e-01 3 119447019 119447172 154 - 2.388 2.384 -0.011
ENSG00000176142 E018 2.261322 0.0117521744 1.102194e-01 2.058676e-01 3 119451209 119451317 109 - 0.379 0.644 1.290
ENSG00000176142 E019 145.572557 0.0003106292 1.978518e-01 3.235360e-01 3 119452447 119452508 62 - 2.189 2.150 -0.131
ENSG00000176142 E020 97.144278 0.0060387412 2.931857e-01 4.342295e-01 3 119452509 119452530 22 - 2.021 1.964 -0.192
ENSG00000176142 E021 138.941457 0.0053519907 3.254000e-01 4.688448e-01 3 119458018 119458083 66 - 2.172 2.120 -0.173
ENSG00000176142 E022 175.987112 0.0005601350 6.612496e-04 2.756800e-03 3 119458084 119458184 101 - 2.296 2.198 -0.326
ENSG00000176142 E023 136.491593 0.0002443865 7.075012e-02 1.445874e-01 3 119458185 119458240 56 - 2.169 2.114 -0.185
ENSG00000176142 E024 187.939318 0.0002127078 3.328171e-02 7.834978e-02 3 119461962 119462104 143 - 2.306 2.250 -0.187
ENSG00000176142 E025 92.271151 0.0015138014 8.844123e-01 9.301265e-01 3 119462105 119462148 44 - 1.970 1.971 0.004
ENSG00000176142 E026 151.986070 0.0035818476 8.458051e-01 9.041039e-01 3 119463336 119463472 137 - 2.186 2.184 -0.008
ENSG00000176142 E027 102.623671 0.0061962204 5.688669e-01 6.954796e-01 3 119463473 119463605 133 - 2.034 1.992 -0.139
ENSG00000176142 E028 22.575955 0.0008436731 4.294629e-03 1.396866e-02 3 119463606 119463683 78 - 1.461 1.248 -0.739
ENSG00000176142 E029 3.090732 0.0525240854 2.425839e-02 6.034556e-02 3 119468735 119468744 10 - 0.759 0.332 -2.046
ENSG00000176142 E030 4.273115 0.0412199772 6.622585e-02 1.370954e-01 3 119468745 119468840 96 - 0.836 0.518 -1.350