ENSG00000176105

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000314574 ENSG00000176105 HEK293_OSMI2_2hA HEK293_TMG_2hB YES1 protein_coding protein_coding 9.575897 2.400088 15.86312 0.1194856 0.8396299 2.719428 6.0300455 1.19478990 12.794361 0.43290001 0.5150531 3.409782 0.60470000 0.498800000 0.8091667 0.31036667 0.294134452 0.004738788 FALSE  
ENST00000577961 ENSG00000176105 HEK293_OSMI2_2hA HEK293_TMG_2hB YES1 protein_coding protein_coding 9.575897 2.400088 15.86312 0.1194856 0.8396299 2.719428 1.5464151 0.97187813 0.000000 0.54027883 0.0000000 -6.617472 0.25062083 0.405366667 0.0000000 -0.40536667 0.064802754 0.004738788 FALSE  
ENST00000584307 ENSG00000176105 HEK293_OSMI2_2hA HEK293_TMG_2hB YES1 protein_coding protein_coding 9.575897 2.400088 15.86312 0.1194856 0.8396299 2.719428 0.9635289 0.21727038 1.624611 0.10863889 0.3530237 2.846465 0.07944167 0.088766667 0.1010667 0.01230000 0.847663397 0.004738788 FALSE  
MSTRG.15391.4 ENSG00000176105 HEK293_OSMI2_2hA HEK293_TMG_2hB YES1 protein_coding   9.575897 2.400088 15.86312 0.1194856 0.8396299 2.719428 0.9827940 0.01614996 1.340054 0.01614996 0.2973154 5.690064 0.06209167 0.007066667 0.0837000 0.07663333 0.004738788 0.004738788 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000176105 E001 150.5428312 0.0163422831 2.126572e-11 4.196154e-10 18 721588 722314 727 - 1.918 2.389 1.576
ENSG00000176105 E002 533.3867030 0.0001271320 1.208613e-16 5.141884e-15 18 722315 724632 2318 - 2.537 2.717 0.600
ENSG00000176105 E003 62.4968389 0.0036556417 2.987995e-01 4.402687e-01 18 732834 732965 132 - 1.646 1.616 -0.102
ENSG00000176105 E004 73.2842558 0.0003827612 2.797226e-01 4.194898e-01 18 736808 736961 154 - 1.714 1.692 -0.073
ENSG00000176105 E005 50.8092425 0.0004607083 4.133006e-02 9.348970e-02 18 739735 739811 77 - 1.569 1.458 -0.381
ENSG00000176105 E006 100.8388270 0.0003048189 4.067932e-04 1.800854e-03 18 742918 743097 180 - 1.865 1.715 -0.507
ENSG00000176105 E007 82.1854516 0.0003244386 3.066280e-06 2.288981e-05 18 743260 743415 156 - 1.790 1.532 -0.875
ENSG00000176105 E008 82.6084963 0.0019616225 2.166852e-04 1.035475e-03 18 745708 745857 150 - 1.785 1.586 -0.674
ENSG00000176105 E009 71.4096630 0.0051208568 1.217522e-02 3.395044e-02 18 745948 746051 104 - 1.717 1.576 -0.480
ENSG00000176105 E010 59.4691403 0.0010127573 1.154756e-05 7.563445e-05 18 747920 748018 99 - 1.654 1.351 -1.041
ENSG00000176105 E011 33.2291470 0.0005827315 2.597592e-05 1.568965e-04 18 751705 751723 19 - 1.417 0.997 -1.493
ENSG00000176105 E012 61.6496862 0.0003749975 1.005857e-06 8.338727e-06 18 751724 751804 81 - 1.672 1.333 -1.163
ENSG00000176105 E013 68.3697280 0.0009581741 9.961067e-10 1.477872e-08 18 756557 756676 120 - 1.724 1.276 -1.540
ENSG00000176105 E014 67.6346072 0.0056805842 4.790884e-05 2.711737e-04 18 756677 756835 159 - 1.709 1.416 -1.001
ENSG00000176105 E015 0.1451727 0.0426947633 8.062440e-01   18 775058 775112 55 - 0.049 0.001 -6.538
ENSG00000176105 E016 0.0000000       18 775189 775266 78 -      
ENSG00000176105 E017 0.1451727 0.0426947633 8.062440e-01   18 787903 787986 84 - 0.049 0.001 -6.538
ENSG00000176105 E018 32.3881164 0.0141360456 5.524090e-02 1.184036e-01 18 812114 812357 244 - 1.388 1.211 -0.621
ENSG00000176105 E019 3.0646961 0.0049770600 7.007927e-01 8.001729e-01 18 812384 812546 163 - 0.496 0.445 -0.256