ENSG00000176092

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000374208 ENSG00000176092 HEK293_OSMI2_2hA HEK293_TMG_2hB CRYBG2 protein_coding processed_transcript 1.768236 3.440353 0.960353 0.6441219 0.1623933 -1.830163 0.5217771 1.2540319 0.1921507 0.65561498 0.1921507 -2.6445297 0.1957417 0.3094667 0.1553667 -0.1541000 0.66951195 0.01177975 FALSE FALSE
ENST00000374211 ENSG00000176092 HEK293_OSMI2_2hA HEK293_TMG_2hB CRYBG2 protein_coding processed_transcript 1.768236 3.440353 0.960353 0.6441219 0.1623933 -1.830163 0.1779767 0.1938803 0.0924238 0.09752941 0.0924238 -0.9931715 0.1151542 0.0485000 0.0953000 0.0468000 0.94170024 0.01177975 FALSE TRUE
ENST00000520372 ENSG00000176092 HEK293_OSMI2_2hA HEK293_TMG_2hB CRYBG2 protein_coding retained_intron 1.768236 3.440353 0.960353 0.6441219 0.1623933 -1.830163 0.3341789 0.3121482 0.4086776 0.09306227 0.1073006 0.3781148 0.1958625 0.1044333 0.4100667 0.3056333 0.01177975 0.01177975   TRUE
MSTRG.605.3 ENSG00000176092 HEK293_OSMI2_2hA HEK293_TMG_2hB CRYBG2 protein_coding   1.768236 3.440353 0.960353 0.6441219 0.1623933 -1.830163 0.6885021 1.5202492 0.2643979 0.15882919 0.1071703 -2.4794252 0.4717000 0.4988000 0.3352667 -0.1635333 0.70636260 0.01177975 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000176092 E001 0.1482932 0.0415728573 1.000000000   1 26321698 26321864 167 - 0.000 0.062 9.030
ENSG00000176092 E002 0.1482932 0.0415728573 1.000000000   1 26321865 26321867 3 - 0.000 0.062 11.022
ENSG00000176092 E003 0.6986918 0.0171964175 0.742374162 0.83127284 1 26321868 26321876 9 - 0.227 0.165 -0.567
ENSG00000176092 E004 4.5879400 0.0040594697 0.350833382 0.49500508 1 26321877 26321962 86 - 0.764 0.611 -0.638
ENSG00000176092 E005 12.6067168 0.0015681876 0.411573911 0.55512283 1 26321963 26322056 94 - 0.932 1.024 0.342
ENSG00000176092 E006 21.8152608 0.0010112702 0.017383006 0.04578346 1 26322164 26322323 160 - 1.026 1.258 0.834
ENSG00000176092 E007 23.5856820 0.0009530706 0.301298939 0.44308998 1 26324152 26324310 159 - 1.188 1.273 0.300
ENSG00000176092 E008 0.4762024 0.2089672843 0.101039377 0.19204598 1 26324790 26324981 192 - 0.375 0.062 -3.148
ENSG00000176092 E009 0.1451727 0.0425060136 0.096298313   1 26325065 26325120 56 - 0.227 0.000 -15.077
ENSG00000176092 E010 18.3508107 0.0011112030 0.187567450 0.31068057 1 26328209 26328332 124 - 1.053 1.182 0.463
ENSG00000176092 E011 0.1817044 0.0409571794 1.000000000   1 26328609 26328733 125 - 0.000 0.062 11.025
ENSG00000176092 E012 18.5944802 0.0012031437 0.277898680 0.41753235 1 26328734 26328873 140 - 1.078 1.182 0.370
ENSG00000176092 E013 16.5017470 0.0011713854 0.129299533 0.23320521 1 26331489 26331584 96 - 1.242 1.094 -0.529
ENSG00000176092 E014 9.2493356 0.0020470420 0.536193778 0.66793992 1 26331585 26331593 9 - 0.965 0.883 -0.312
ENSG00000176092 E015 10.2373286 0.0017317777 0.133071257 0.23840324 1 26331594 26331618 25 - 1.078 0.900 -0.662
ENSG00000176092 E016 3.9082790 0.0052204991 0.008947404 0.02614823 1 26336095 26336207 113 - 0.896 0.500 -1.668
ENSG00000176092 E017 12.5159886 0.0019639749 0.978794404 0.99081830 1 26336338 26336370 33 - 1.026 1.017 -0.031
ENSG00000176092 E018 11.7903911 0.0017030132 0.536043664 0.66781330 1 26336371 26336465 95 - 1.053 0.977 -0.279
ENSG00000176092 E019 0.1451727 0.0425060136 0.096298313   1 26336466 26336605 140 - 0.227 0.000 -15.077
ENSG00000176092 E020 1.3577419 0.0543872980 0.190172266 0.31399034 1 26336606 26336732 127 - 0.000 0.320 13.413
ENSG00000176092 E021 0.6245948 0.1534520610 0.672446860 0.77841010 1 26336841 26336980 140 - 0.000 0.168 12.345
ENSG00000176092 E022 0.1515154 0.0485719809 0.095650564   1 26337147 26337252 106 - 0.227 0.000 -15.060
ENSG00000176092 E023 0.0000000       1 26337253 26337379 127 -      
ENSG00000176092 E024 0.0000000       1 26337538 26337674 137 -      
ENSG00000176092 E025 0.0000000       1 26338012 26338047 36 -      
ENSG00000176092 E026 0.0000000       1 26338351 26338477 127 -      
ENSG00000176092 E027 0.0000000       1 26339290 26339429 140 -      
ENSG00000176092 E028 0.0000000       1 26342754 26342883 130 -      
ENSG00000176092 E029 0.0000000       1 26343047 26343159 113 -      
ENSG00000176092 E030 0.0000000       1 26343246 26343291 46 -      
ENSG00000176092 E031 0.0000000       1 26343292 26343293 2 -      
ENSG00000176092 E032 0.0000000       1 26343745 26344523 779 -      
ENSG00000176092 E033 0.1451727 0.0425060136 0.096298313   1 26344524 26345354 831 - 0.227 0.000 -15.077
ENSG00000176092 E034 0.1451727 0.0425060136 0.096298313   1 26345355 26345478 124 - 0.227 0.000 -15.077
ENSG00000176092 E035 0.0000000       1 26345479 26346458 980 -      
ENSG00000176092 E036 0.0000000       1 26346459 26346612 154 -      
ENSG00000176092 E037 0.0000000       1 26346613 26346712 100 -      
ENSG00000176092 E038 0.0000000       1 26354036 26354045 10 -      
ENSG00000176092 E039 0.0000000       1 26354046 26354785 740 -      
ENSG00000176092 E040 0.0000000       1 26356459 26356522 64 -      
ENSG00000176092 E041 0.0000000       1 26359937 26360080 144 -