ENSG00000175984

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000393274 ENSG00000175984 HEK293_OSMI2_2hA HEK293_TMG_2hB DENND2C protein_coding protein_coding 2.159689 0.7771645 3.473688 0.2405826 0.1444662 2.145878 0.36668690 0.12755375 0.70644029 0.044340149 0.23249267 2.3808510 0.17066250 0.2131333 0.20820000 -0.004933333 0.989810996 0.004442171 FALSE TRUE
ENST00000393276 ENSG00000175984 HEK293_OSMI2_2hA HEK293_TMG_2hB DENND2C protein_coding protein_coding 2.159689 0.7771645 3.473688 0.2405826 0.1444662 2.145878 0.41211083 0.27410429 0.45478514 0.066400574 0.25830574 0.7101433 0.29702083 0.4016000 0.13260000 -0.269000000 0.382176037 0.004442171 FALSE TRUE
ENST00000393277 ENSG00000175984 HEK293_OSMI2_2hA HEK293_TMG_2hB DENND2C protein_coding protein_coding 2.159689 0.7771645 3.473688 0.2405826 0.1444662 2.145878 0.08777568 0.00000000 0.37063283 0.000000000 0.37063283 5.2503281 0.03076667 0.0000000 0.11300000 0.113000000 1.000000000 0.004442171 TRUE TRUE
ENST00000481894 ENSG00000175984 HEK293_OSMI2_2hA HEK293_TMG_2hB DENND2C protein_coding processed_transcript 2.159689 0.7771645 3.473688 0.2405826 0.1444662 2.145878 0.09632171 0.03926075 0.15831319 0.009332499 0.02630777 1.7726379 0.05625833 0.0557000 0.04513333 -0.010566667 0.834271584 0.004442171 TRUE TRUE
ENST00000495031 ENSG00000175984 HEK293_OSMI2_2hA HEK293_TMG_2hB DENND2C protein_coding processed_transcript 2.159689 0.7771645 3.473688 0.2405826 0.1444662 2.145878 0.16969282 0.30830822 0.09322965 0.221800915 0.09322965 -1.6245670 0.14822500 0.2895000 0.02483333 -0.264666667 0.253763127 0.004442171 FALSE TRUE
MSTRG.1863.3 ENSG00000175984 HEK293_OSMI2_2hA HEK293_TMG_2hB DENND2C protein_coding   2.159689 0.7771645 3.473688 0.2405826 0.1444662 2.145878 0.67692353 0.00000000 1.05394763 0.000000000 0.52709516 6.7332833 0.19202917 0.0000000 0.29616667 0.296166667 0.377891793 0.004442171 TRUE TRUE
MSTRG.1863.6 ENSG00000175984 HEK293_OSMI2_2hA HEK293_TMG_2hB DENND2C protein_coding   2.159689 0.7771645 3.473688 0.2405826 0.1444662 2.145878 0.33514344 0.00000000 0.57655216 0.000000000 0.18487715 5.8741875 0.09667500 0.0000000 0.16243333 0.162433333 0.004442171 0.004442171 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000175984 E001 0.2965864 0.0387260103 1.347249e-02   1 114582848 114582849 2 - 0.000 0.403 11.896
ENSG00000175984 E002 0.5180316 0.0217681645 1.999120e-03 7.223346e-03 1 114582850 114582850 1 - 0.000 0.518 15.166
ENSG00000175984 E003 35.2562663 0.0264934653 1.255216e-08 1.520052e-07 1 114582851 114583324 474 - 1.274 1.863 2.015
ENSG00000175984 E004 18.3715255 0.0012575170 7.358098e-05 3.973575e-04 1 114583325 114583554 230 - 1.086 1.468 1.343
ENSG00000175984 E005 4.2929616 0.0037445735 5.120495e-01 6.469886e-01 1 114583555 114583602 48 - 0.606 0.748 0.599
ENSG00000175984 E006 28.2080245 0.0043560466 2.885375e-04 1.333233e-03 1 114583603 114584531 929 - 1.278 1.595 1.096
ENSG00000175984 E007 5.0422228 0.0069827917 1.888913e-01 3.123680e-01 1 114584532 114584569 38 - 0.723 0.518 -0.897
ENSG00000175984 E008 43.2599170 0.0009735826 3.672049e-01 5.115800e-01 1 114584570 114585631 1062 - 1.538 1.521 -0.059
ENSG00000175984 E009 1.7841796 0.0092088580 9.976503e-01 1.000000e+00 1 114586736 114587386 651 - 0.377 0.404 0.150
ENSG00000175984 E010 12.3929315 0.0015045937 4.210956e-01 5.642336e-01 1 114587387 114587473 87 - 1.034 0.975 -0.217
ENSG00000175984 E011 23.7604611 0.0008921469 6.483415e-02 1.347682e-01 1 114587716 114587952 237 - 1.305 1.170 -0.475
ENSG00000175984 E012 0.0000000       1 114588520 114588557 38 -      
ENSG00000175984 E013 17.2787918 0.0011288504 3.220033e-01 4.652730e-01 1 114594473 114594578 106 - 1.162 1.097 -0.234
ENSG00000175984 E014 0.7019140 0.0180140037 1.228114e-01 2.239680e-01 1 114595355 114595650 296 - 0.106 0.404 2.476
ENSG00000175984 E015 13.0449750 0.0013023555 7.007242e-01 8.001332e-01 1 114595832 114595873 42 - 1.044 1.040 -0.016
ENSG00000175984 E016 21.5653115 0.0010112702 4.000525e-01 5.437732e-01 1 114599274 114599451 178 - 1.252 1.213 -0.135
ENSG00000175984 E017 15.4324721 0.0113720157 9.695997e-01 9.849843e-01 1 114600204 114600352 149 - 1.101 1.146 0.164
ENSG00000175984 E018 13.7861033 0.0029502223 7.724478e-01 8.531315e-01 1 114600820 114600960 141 - 1.050 1.123 0.264
ENSG00000175984 E019 8.7079019 0.0020613990 3.871564e-01 5.313051e-01 1 114601508 114601585 78 - 0.858 1.009 0.567
ENSG00000175984 E020 10.4924013 0.0019795058 1.121940e-01 2.087489e-01 1 114602125 114602194 70 - 0.987 0.804 -0.696
ENSG00000175984 E021 12.3220582 0.0016366591 1.461819e-01 2.564898e-01 1 114604922 114605031 110 - 1.044 0.898 -0.546
ENSG00000175984 E022 17.1173367 0.0023025334 6.420750e-02 1.337106e-01 1 114608686 114608873 188 - 1.178 1.009 -0.614
ENSG00000175984 E023 8.5089106 0.0019854891 2.101109e-01 3.386757e-01 1 114611073 114611117 45 - 0.898 0.748 -0.585
ENSG00000175984 E024 12.2075550 0.0013798956 8.045098e-02 1.602717e-01 1 114618386 114618482 97 - 1.045 0.853 -0.716
ENSG00000175984 E025 14.8121668 0.0055594762 4.014344e-02 9.130046e-02 1 114621895 114622065 171 - 1.123 0.898 -0.831
ENSG00000175984 E026 11.8255796 0.0106105882 3.986451e-01 5.423764e-01 1 114622987 114623099 113 - 1.016 0.938 -0.290
ENSG00000175984 E027 6.7627448 0.0852643639 9.458495e-01 9.700051e-01 1 114623507 114623559 53 - 0.785 0.808 0.090
ENSG00000175984 E028 8.3986312 0.0057502969 6.922577e-01 7.935371e-01 1 114623560 114623643 84 - 0.874 0.854 -0.080
ENSG00000175984 E029 25.8270722 0.0007611431 1.304375e-04 6.607219e-04 1 114625179 114625697 519 - 1.363 1.009 -1.263
ENSG00000175984 E030 25.6894027 0.0007506158 1.266684e-05 8.220669e-05 1 114625698 114626188 491 - 1.369 0.938 -1.544
ENSG00000175984 E031 0.1515154 0.0443601255 1.000000e+00   1 114626189 114626193 5 - 0.056 0.000 -9.769
ENSG00000175984 E032 2.6810126 0.0694737391 2.076201e-01 3.356276e-01 1 114645448 114645559 112 - 0.524 0.247 -1.610
ENSG00000175984 E033 2.4012763 0.0211060058 2.293960e-01 3.617161e-01 1 114654505 114654761 257 - 0.487 0.247 -1.433
ENSG00000175984 E034 5.2398229 0.0176401908 1.192055e-02 3.334385e-02 1 114669983 114670111 129 - 0.756 0.247 -2.615
ENSG00000175984 E035 0.3686942 0.0342990405 2.358494e-01 3.693780e-01 1 114670241 114670422 182 - 0.056 0.248 2.478