ENSG00000175931

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000319380 ENSG00000175931 HEK293_OSMI2_2hA HEK293_TMG_2hB UBE2O protein_coding protein_coding 54.61192 70.64229 39.50335 4.639099 0.9196024 -0.8383962 36.322959 48.4380434 26.407257 2.9904418 0.36748673 -0.8749577 0.6566125 0.686366667 0.6688333 -0.01753333 7.676661e-01 2.286481e-19 FALSE  
ENST00000586409 ENSG00000175931 HEK293_OSMI2_2hA HEK293_TMG_2hB UBE2O protein_coding retained_intron 54.61192 70.64229 39.50335 4.639099 0.9196024 -0.8383962 1.700079 0.6948449 2.382339 0.1277042 0.09296963 1.7630442 0.0357000 0.009666667 0.0603000 0.05063333 2.286481e-19 2.286481e-19 FALSE  
ENST00000587127 ENSG00000175931 HEK293_OSMI2_2hA HEK293_TMG_2hB UBE2O protein_coding protein_coding 54.61192 70.64229 39.50335 4.639099 0.9196024 -0.8383962 12.422072 19.3927888 7.142729 1.8323790 0.69590954 -1.4396983 0.2225583 0.274233333 0.1801667 -0.09406667 1.032010e-02 2.286481e-19 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000175931 E001 370.925172 0.0123636516 3.547688e-09 4.748137e-08 17 76389456 76389657 202 - 2.225 2.627 1.341
ENSG00000175931 E002 560.393384 0.0090955211 5.192897e-11 9.619426e-10 17 76389658 76389796 139 - 2.424 2.801 1.255
ENSG00000175931 E003 2750.010252 0.0021342681 2.215680e-15 8.001411e-14 17 76389797 76391158 1362 - 3.252 3.459 0.687
ENSG00000175931 E004 428.401258 0.0001366364 5.161331e-06 3.661756e-05 17 76391159 76391230 72 - 2.498 2.632 0.445
ENSG00000175931 E005 500.107908 0.0016710851 2.899700e-05 1.731348e-04 17 76391231 76391353 123 - 2.550 2.707 0.523
ENSG00000175931 E006 718.696107 0.0001304443 9.271294e-08 9.470608e-07 17 76391354 76391613 260 - 2.727 2.854 0.421
ENSG00000175931 E007 360.953398 0.0001404890 8.230875e-01 8.884933e-01 17 76391756 76391813 58 - 2.486 2.535 0.164
ENSG00000175931 E008 581.019907 0.0001857587 7.716194e-01 8.525964e-01 17 76391910 76392113 204 - 2.698 2.738 0.134
ENSG00000175931 E009 25.784016 0.0007489282 2.873584e-08 3.247114e-07 17 76395358 76395724 367 - 1.591 1.255 -1.161
ENSG00000175931 E010 340.393313 0.0020486172 1.292147e-01 2.330899e-01 17 76395725 76395861 137 - 2.428 2.522 0.313
ENSG00000175931 E011 15.521002 0.0013230723 1.947237e-14 6.146253e-13 17 76395862 76396127 266 - 1.505 0.887 -2.207
ENSG00000175931 E012 1199.573133 0.0004568483 3.754193e-02 8.648432e-02 17 76396128 76396821 694 - 3.031 3.048 0.058
ENSG00000175931 E013 236.062018 0.0001765139 2.430495e-05 1.478882e-04 17 76397799 76397807 9 - 2.377 2.317 -0.199
ENSG00000175931 E014 410.178103 0.0004004954 6.588783e-08 6.933814e-07 17 76397808 76397888 81 - 2.620 2.556 -0.215
ENSG00000175931 E015 26.622381 0.0009042799 7.052363e-02 1.442117e-01 17 76397889 76397891 3 - 1.467 1.384 -0.286
ENSG00000175931 E016 504.822435 0.0001643963 2.579729e-11 5.023868e-10 17 76398255 76398383 129 - 2.714 2.644 -0.232
ENSG00000175931 E017 412.046402 0.0004371238 7.876444e-07 6.690042e-06 17 76398472 76398584 113 - 2.618 2.562 -0.187
ENSG00000175931 E018 416.151775 0.0001518807 7.710962e-09 9.705791e-08 17 76398837 76398991 155 - 2.626 2.562 -0.211
ENSG00000175931 E019 1.516634 0.0092560655 4.743530e-01 6.131953e-01 17 76399308 76399448 141 - 0.442 0.342 -0.563
ENSG00000175931 E020 641.293237 0.0003462318 1.178624e-12 2.858254e-11 17 76399449 76399788 340 - 2.819 2.746 -0.243
ENSG00000175931 E021 349.516507 0.0007166341 4.935854e-05 2.784891e-04 17 76399789 76399921 133 - 2.541 2.492 -0.165
ENSG00000175931 E022 213.539402 0.0002054890 3.218690e-02 7.621282e-02 17 76400147 76400221 75 - 2.301 2.289 -0.040
ENSG00000175931 E023 212.063272 0.0016672733 5.013777e-03 1.596861e-02 17 76400222 76400297 76 - 2.320 2.276 -0.147
ENSG00000175931 E024 268.544223 0.0025910149 9.097903e-04 3.648186e-03 17 76400441 76400550 110 - 2.436 2.373 -0.209
ENSG00000175931 E025 329.688952 0.0026766596 1.452538e-05 9.294072e-05 17 76401011 76401154 144 - 2.543 2.453 -0.301
ENSG00000175931 E026 20.597410 0.0009082292 1.116520e-06 9.177030e-06 17 76401731 76402063 333 - 1.492 1.166 -1.139
ENSG00000175931 E027 245.632311 0.0018703540 4.911058e-07 4.349220e-06 17 76402064 76402127 64 - 2.428 2.318 -0.367
ENSG00000175931 E028 293.261586 0.0018550306 4.814171e-12 1.055590e-10 17 76402602 76402699 98 - 2.535 2.378 -0.523
ENSG00000175931 E029 245.953151 0.0003062157 3.237391e-21 2.378108e-19 17 76405206 76405316 111 - 2.475 2.291 -0.613
ENSG00000175931 E030 169.518183 0.0004799648 1.288805e-18 7.000006e-17 17 76405513 76405572 60 - 2.329 2.116 -0.711
ENSG00000175931 E031 229.829256 0.0091124557 2.472578e-10 4.073594e-09 17 76452725 76453152 428 - 2.498 2.222 -0.922