ENSG00000175866

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000321280 ENSG00000175866 HEK293_OSMI2_2hA HEK293_TMG_2hB BAIAP2 protein_coding protein_coding 44.96064 78.50762 31.31147 2.097114 1.956287 -1.325865 9.517836 16.274963 7.5823178 1.6415458 0.3247144 -1.1009282 0.21765000 0.2065000 0.24316667 0.03666667 0.476053400 0.003059353 FALSE  
ENST00000435091 ENSG00000175866 HEK293_OSMI2_2hA HEK293_TMG_2hB BAIAP2 protein_coding protein_coding 44.96064 78.50762 31.31147 2.097114 1.956287 -1.325865 5.601052 11.233517 0.9861905 0.6047390 0.6150017 -3.4965278 0.10295000 0.1429000 0.03336667 -0.10953333 0.291490382 0.003059353 FALSE  
ENST00000572498 ENSG00000175866 HEK293_OSMI2_2hA HEK293_TMG_2hB BAIAP2 protein_coding protein_coding 44.96064 78.50762 31.31147 2.097114 1.956287 -1.325865 12.209470 24.897108 6.9038134 1.0221353 0.5968268 -1.8490040 0.25197500 0.3183000 0.22010000 -0.09820000 0.014632123 0.003059353 FALSE  
ENST00000575245 ENSG00000175866 HEK293_OSMI2_2hA HEK293_TMG_2hB BAIAP2 protein_coding protein_coding 44.96064 78.50762 31.31147 2.097114 1.956287 -1.325865 2.309209 4.616301 2.4146086 0.5802403 0.1615199 -0.9321073 0.05475417 0.0585000 0.07756667 0.01906667 0.365386201 0.003059353 FALSE  
MSTRG.15251.2 ENSG00000175866 HEK293_OSMI2_2hA HEK293_TMG_2hB BAIAP2 protein_coding   44.96064 78.50762 31.31147 2.097114 1.956287 -1.325865 11.188555 17.150133 9.8143594 1.0298948 0.9496965 -0.8046255 0.26816250 0.2183667 0.31226667 0.09390000 0.003059353 0.003059353 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000175866 E001 0.2955422 0.0295041760 4.473610e-01   17 81035122 81035147 26 + 0.189 0.077 -1.492
ENSG00000175866 E002 0.2955422 0.0295041760 4.473610e-01   17 81035148 81035149 2 + 0.189 0.077 -1.492
ENSG00000175866 E003 0.2955422 0.0295041760 4.473610e-01   17 81035150 81035150 1 + 0.189 0.077 -1.492
ENSG00000175866 E004 0.4772466 0.0206271818 7.706907e-01 8.519523e-01 17 81035151 81035152 2 + 0.189 0.142 -0.491
ENSG00000175866 E005 2.0187838 0.0102113223 9.322887e-01 9.613451e-01 17 81035153 81035155 3 + 0.421 0.439 0.095
ENSG00000175866 E006 6.1033563 0.0404153189 2.038597e-01 3.310300e-01 17 81035156 81035157 2 + 0.936 0.748 -0.730
ENSG00000175866 E007 53.3701161 0.0008366274 1.367771e-15 5.082781e-14 17 81035158 81035161 4 + 1.932 1.536 -1.340
ENSG00000175866 E008 139.5534514 0.0002776563 2.826179e-07 2.629721e-06 17 81035162 81035175 14 + 2.190 2.024 -0.554
ENSG00000175866 E009 290.0445649 0.0014306375 1.507677e-04 7.504793e-04 17 81035176 81035308 133 + 2.462 2.359 -0.343
ENSG00000175866 E010 0.1482932 0.0417766449 1.000000e+00   17 81036003 81036057 55 + 0.000 0.077 11.593
ENSG00000175866 E011 28.5162650 0.0028747277 3.113140e-01 4.537603e-01 17 81036863 81036961 99 + 1.443 1.369 -0.253
ENSG00000175866 E012 0.5451131 0.6953841819 7.191148e-01 8.140423e-01 17 81053362 81053454 93 + 0.000 0.201 12.154
ENSG00000175866 E013 301.8803681 0.0021094830 1.719315e-03 6.343298e-03 17 81053668 81053739 72 + 2.470 2.380 -0.302
ENSG00000175866 E014 178.0493164 0.0017044618 4.204703e-03 1.371573e-02 17 81053740 81053743 4 + 2.246 2.150 -0.319
ENSG00000175866 E015 1.2888458 0.0102132314 1.544553e-01 2.676940e-01 17 81053744 81053791 48 + 0.503 0.250 -1.490
ENSG00000175866 E016 1.5113352 0.0093629690 6.337145e-01 7.483467e-01 17 81056362 81056477 116 + 0.421 0.335 -0.489
ENSG00000175866 E017 1.0695761 0.0125407414 6.981117e-01 7.981411e-01 17 81057336 81057526 191 + 0.320 0.250 -0.487
ENSG00000175866 E018 0.1451727 0.0431238052 1.665832e-01   17 81057615 81057648 34 + 0.189 0.000 -14.175
ENSG00000175866 E019 0.1451727 0.0431238052 1.665832e-01   17 81057734 81057743 10 + 0.189 0.000 -14.175
ENSG00000175866 E020 0.2966881 0.0272705136 3.902520e-02   17 81057744 81057794 51 + 0.320 0.000 -15.414
ENSG00000175866 E021 302.4152469 0.0016056552 4.876089e-03 1.558405e-02 17 81057881 81057967 87 + 2.461 2.385 -0.255
ENSG00000175866 E022 0.1482932 0.0417766449 1.000000e+00   17 81063740 81063856 117 + 0.000 0.077 11.593
ENSG00000175866 E023 0.0000000       17 81076265 81076502 238 +      
ENSG00000175866 E024 0.2998086 0.0292575965 4.467583e-01   17 81082989 81083407 419 + 0.189 0.077 -1.492
ENSG00000175866 E025 0.1817044 0.0399028081 1.000000e+00   17 81083567 81083909 343 + 0.000 0.077 11.614
ENSG00000175866 E026 235.8608010 0.0028581584 1.894261e-02 4.920636e-02 17 81084832 81084893 62 + 2.355 2.277 -0.261
ENSG00000175866 E027 0.1482932 0.0417766449 1.000000e+00   17 81084894 81085094 201 + 0.000 0.077 11.593
ENSG00000175866 E028 0.1482932 0.0417766449 1.000000e+00   17 81085095 81085582 488 + 0.000 0.077 11.593
ENSG00000175866 E029 0.5911836 0.0300004416 4.005353e-01 5.442258e-01 17 81085583 81085653 71 + 0.000 0.200 13.293
ENSG00000175866 E030 235.4455142 0.0002049643 8.304501e-02 1.643232e-01 17 81085654 81085715 62 + 2.326 2.284 -0.140
ENSG00000175866 E031 162.9305915 0.0002067472 8.220277e-02 1.629817e-01 17 81085716 81085725 10 + 2.174 2.123 -0.171
ENSG00000175866 E032 191.6325062 0.0005320451 8.682072e-02 1.703036e-01 17 81086443 81086460 18 + 2.240 2.192 -0.161
ENSG00000175866 E033 320.0164062 0.0002009183 4.400764e-01 5.817904e-01 17 81086461 81086580 120 + 2.438 2.424 -0.046
ENSG00000175866 E034 0.5848540 0.0363348033 4.008824e-01 5.445622e-01 17 81086934 81087022 89 + 0.000 0.200 13.225
ENSG00000175866 E035 0.3332198 0.0291165774 4.479339e-01   17 81087492 81087847 356 + 0.189 0.077 -1.489
ENSG00000175866 E036 0.2934659 0.0295245458 4.474220e-01   17 81097579 81097696 118 + 0.189 0.077 -1.491
ENSG00000175866 E037 0.0000000       17 81098118 81098195 78 +      
ENSG00000175866 E038 310.6742015 0.0001602654 7.970884e-01 8.705122e-01 17 81099928 81100080 153 + 2.415 2.413 -0.007
ENSG00000175866 E039 323.7998419 0.0001943356 8.038445e-02 1.601633e-01 17 81103502 81103723 222 + 2.396 2.441 0.150
ENSG00000175866 E040 0.0000000       17 81103724 81103747 24 +      
ENSG00000175866 E041 269.6655506 0.0001986279 1.212329e-01 2.216890e-01 17 81103907 81104001 95 + 2.317 2.361 0.146
ENSG00000175866 E042 315.7788354 0.0023341755 8.605657e-01 9.140705e-01 17 81104002 81104108 107 + 2.411 2.424 0.043
ENSG00000175866 E043 11.0670600 0.0022986894 3.668626e-01 5.111986e-01 17 81104511 81104513 3 + 1.076 0.980 -0.351
ENSG00000175866 E044 446.7936290 0.0001928803 2.067090e-01 3.346156e-01 17 81104514 81104715 202 + 2.548 2.577 0.098
ENSG00000175866 E045 7.7145059 0.0057846201 4.148794e-01 5.582894e-01 17 81105086 81106077 992 + 0.936 0.835 -0.386
ENSG00000175866 E046 272.5013932 0.0002254380 1.527463e-03 5.726110e-03 17 81106078 81106146 69 + 2.289 2.376 0.289
ENSG00000175866 E047 367.6309056 0.0001605305 2.383232e-08 2.737170e-07 17 81106745 81106907 163 + 2.383 2.513 0.435
ENSG00000175866 E048 18.6219673 0.0009687963 1.853248e-01 3.079027e-01 17 81106908 81108474 1567 + 1.114 1.243 0.461
ENSG00000175866 E049 194.4858659 0.0026250037 4.306384e-06 3.108995e-05 17 81108475 81108509 35 + 2.061 2.252 0.640
ENSG00000175866 E050 15.9361980 0.0023617045 7.495389e-02 1.514612e-01 17 81108510 81108967 458 + 1.266 1.103 -0.579
ENSG00000175866 E051 79.3921057 0.0003658395 9.111560e-02 1.768749e-01 17 81108968 81109387 420 + 1.757 1.841 0.285
ENSG00000175866 E052 60.3199559 0.0019508740 4.911341e-03 1.568349e-02 17 81110277 81110512 236 + 1.574 1.746 0.584
ENSG00000175866 E053 6.2485213 0.0034889006 7.372323e-03 2.218548e-02 17 81110914 81110955 42 + 0.421 0.870 1.969
ENSG00000175866 E054 4.7070858 0.0050083135 5.666913e-02 1.208823e-01 17 81110956 81110959 4 + 0.421 0.753 1.510
ENSG00000175866 E055 183.4114961 0.0040816274 1.200534e-03 4.642247e-03 17 81115770 81115817 48 + 2.069 2.220 0.506
ENSG00000175866 E056 335.4013050 0.0077536713 1.306409e-05 8.444341e-05 17 81115818 81116229 412 + 2.273 2.492 0.730
ENSG00000175866 E057 8.0122382 0.0051251710 3.417638e-01 4.856955e-01 17 81116230 81116312 83 + 0.963 0.847 -0.439
ENSG00000175866 E058 13.2405564 0.0022200517 8.997666e-02 1.751018e-01 17 81116313 81116756 444 + 1.197 1.030 -0.599
ENSG00000175866 E059 20.2814804 0.0019854237 3.738144e-03 1.240506e-02 17 81116757 81117434 678 + 1.416 1.182 -0.821