ENSG00000175727

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000319080 ENSG00000175727 HEK293_OSMI2_2hA HEK293_TMG_2hB MLXIP protein_coding protein_coding 21.19515 24.51537 18.45397 2.17564 0.1979537 -0.4095622 16.126398 21.4726921 12.512973 1.6603480 0.1306987 -0.7785977 0.7482000 0.87786667 0.67816667 -0.19970000 9.831464e-12 9.831464e-12 FALSE TRUE
ENST00000542417 ENSG00000175727 HEK293_OSMI2_2hA HEK293_TMG_2hB MLXIP protein_coding protein_coding 21.19515 24.51537 18.45397 2.17564 0.1979537 -0.4095622 0.594457 0.4298368 1.268617 0.1496232 0.3705081 1.5395439 0.0295625 0.01690000 0.06846667 0.05156667 2.047448e-02 9.831464e-12 FALSE FALSE
MSTRG.8206.6 ENSG00000175727 HEK293_OSMI2_2hA HEK293_TMG_2hB MLXIP protein_coding   21.19515 24.51537 18.45397 2.17564 0.1979537 -0.4095622 1.437239 0.6184219 1.387123 0.3721864 0.2586444 1.1526542 0.0712125 0.02393333 0.07540000 0.05146667 1.595702e-01 9.831464e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000175727 E001 28.2011521 0.0242541457 2.632480e-09 3.611001e-08 12 122078756 122078980 225 + 1.681 1.173 -1.755
ENSG00000175727 E002 17.8093371 0.0141906931 2.496779e-11 4.876866e-10 12 122078981 122079029 49 + 1.514 0.928 -2.084
ENSG00000175727 E003 14.7354573 0.0015090578 2.424285e-13 6.525625e-12 12 122079030 122079046 17 + 1.437 0.860 -2.078
ENSG00000175727 E004 23.9688729 0.0008106403 3.344726e-15 1.181518e-13 12 122079047 122079084 38 + 1.604 1.130 -1.650
ENSG00000175727 E005 99.1539028 0.0059199644 3.506743e-13 9.226972e-12 12 122079085 122079266 182 + 2.133 1.856 -0.929
ENSG00000175727 E006 121.2143974 0.0005303702 5.737996e-14 1.687960e-12 12 122127256 122127362 107 + 2.161 2.003 -0.529
ENSG00000175727 E007 0.0000000       12 122127880 122127882 3 +      
ENSG00000175727 E008 62.5212897 0.0005800452 4.888778e-05 2.761620e-04 12 122127883 122127887 5 + 1.841 1.749 -0.313
ENSG00000175727 E009 122.8318401 0.0002911814 9.901892e-14 2.815374e-12 12 122127888 122127968 81 + 2.162 2.014 -0.496
ENSG00000175727 E010 1.8112455 0.0122291579 3.504743e-01 4.946421e-01 12 122127969 122129136 1168 + 0.497 0.396 -0.524
ENSG00000175727 E011 102.5647668 0.0002814629 1.049738e-13 2.973532e-12 12 122129137 122129179 43 + 2.097 1.929 -0.564
ENSG00000175727 E012 101.0656442 0.0003237814 7.304962e-11 1.318505e-09 12 122129180 122129226 47 + 2.074 1.935 -0.467
ENSG00000175727 E013 93.7926105 0.0015951644 4.793982e-08 5.193604e-07 12 122129588 122129629 42 + 2.036 1.906 -0.435
ENSG00000175727 E014 2.5528012 0.0060037450 7.754076e-02 1.555125e-01 12 122129630 122129940 311 + 0.659 0.445 -0.999
ENSG00000175727 E015 66.4566765 0.0080325881 1.403549e-04 7.050945e-04 12 122129941 122129941 1 + 1.892 1.755 -0.461
ENSG00000175727 E016 156.5737419 0.0058321316 7.448673e-04 3.060353e-03 12 122129942 122130112 171 + 2.221 2.163 -0.194
ENSG00000175727 E017 114.1863775 0.0099363467 7.208311e-03 2.176660e-02 12 122130844 122130933 90 + 2.084 2.029 -0.187
ENSG00000175727 E018 96.7238602 0.0084477438 5.259772e-03 1.663769e-02 12 122132292 122132383 92 + 2.016 1.954 -0.205
ENSG00000175727 E019 4.0032619 0.0692399674 8.997296e-01 9.400256e-01 12 122132525 122133297 773 + 0.623 0.719 0.403
ENSG00000175727 E020 1.0298353 0.0121989077 7.298573e-01 8.219599e-01 12 122133298 122133347 50 + 0.234 0.340 0.739
ENSG00000175727 E021 124.4657171 0.0036762794 5.717696e-04 2.428210e-03 12 122133348 122133529 182 + 2.119 2.067 -0.173
ENSG00000175727 E022 56.5345964 0.0003955490 6.659182e-03 2.033793e-02 12 122133530 122133583 54 + 1.769 1.732 -0.125
ENSG00000175727 E023 71.2373272 0.0003380039 1.008960e-02 2.898191e-02 12 122133584 122133670 87 + 1.857 1.839 -0.058
ENSG00000175727 E024 190.9907703 0.0002035575 1.378400e-06 1.110592e-05 12 122133671 122133987 317 + 2.290 2.257 -0.112
ENSG00000175727 E025 10.9697212 0.0015472472 8.340264e-02 1.648930e-01 12 122133988 122134164 177 + 0.890 1.158 0.983
ENSG00000175727 E026 10.1471211 0.0017181022 1.150784e-02 3.236722e-02 12 122134321 122135223 903 + 1.129 0.956 -0.635
ENSG00000175727 E027 59.5386557 0.0004406858 2.574612e-03 8.988178e-03 12 122135224 122135234 11 + 1.794 1.746 -0.163
ENSG00000175727 E028 56.6676015 0.0005253356 1.063899e-03 4.180284e-03 12 122135235 122135235 1 + 1.782 1.718 -0.217
ENSG00000175727 E029 119.7702792 0.0002766095 4.067234e-05 2.339959e-04 12 122135236 122135345 110 + 2.093 2.050 -0.144
ENSG00000175727 E030 0.9661334 0.2276357212 3.354720e-01 4.792634e-01 12 122135454 122135488 35 + 0.133 0.389 2.020
ENSG00000175727 E031 115.1092674 0.0003086092 1.265341e-03 4.861387e-03 12 122135489 122135627 139 + 2.062 2.046 -0.055
ENSG00000175727 E032 61.2431538 0.0005279076 2.790479e-01 4.187494e-01 12 122135628 122135666 39 + 1.761 1.802 0.140
ENSG00000175727 E033 22.2436166 0.0481882209 4.049929e-04 1.793933e-03 12 122135667 122137293 1627 + 1.544 1.158 -1.343
ENSG00000175727 E034 5.7906925 0.0033374748 1.706039e-03 6.301305e-03 12 122137294 122137468 175 + 0.980 0.660 -1.261
ENSG00000175727 E035 107.8250878 0.0050930905 1.880890e-02 4.891338e-02 12 122137469 122137590 122 + 2.040 2.019 -0.070
ENSG00000175727 E036 6.6468637 0.0341443004 1.330738e-02 3.663616e-02 12 122138191 122138193 3 + 1.011 0.740 -1.041
ENSG00000175727 E037 118.5600264 0.0067224024 3.803407e-03 1.259120e-02 12 122138194 122138295 102 + 2.100 2.045 -0.184
ENSG00000175727 E038 6.8141548 0.0026813177 2.212816e-01 3.519619e-01 12 122138296 122138423 128 + 0.910 0.842 -0.260
ENSG00000175727 E039 130.9391791 0.0017220851 4.356099e-03 1.413729e-02 12 122138424 122138551 128 + 2.115 2.104 -0.037
ENSG00000175727 E040 110.6814993 0.0003706003 5.592577e-01 6.873931e-01 12 122138815 122138938 124 + 1.991 2.063 0.241
ENSG00000175727 E041 1.7736656 0.4035941275 4.688378e-01 6.081971e-01 12 122138939 122138941 3 + 0.235 0.513 1.658
ENSG00000175727 E042 6.3883023 0.0230142438 3.626251e-01 5.070355e-01 12 122140827 122140953 127 + 0.870 0.827 -0.168
ENSG00000175727 E043 120.1949332 0.0014812394 1.728702e-01 2.919261e-01 12 122140954 122141083 130 + 2.046 2.089 0.144
ENSG00000175727 E044 1044.8562887 0.0013250222 4.371778e-01 5.791911e-01 12 122141691 122143415 1725 + 2.958 3.042 0.281
ENSG00000175727 E045 2359.4390507 0.0026895692 1.835968e-25 2.105440e-23 12 122143416 122147062 3647 + 3.171 3.461 0.966
ENSG00000175727 E046 331.9213178 0.0058179365 9.187434e-19 5.099712e-17 12 122147063 122147344 282 + 2.173 2.652 1.600