ENSG00000175662

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000379504 ENSG00000175662 HEK293_OSMI2_2hA HEK293_TMG_2hB TOM1L2 protein_coding protein_coding 10.40586 14.49526 6.108049 0.7455219 0.3864729 -1.245432 7.6145266 10.08291947 4.50058819 0.97192946 0.16203966 -1.161956 0.72847917 0.692666667 0.739333333 0.04666667 0.69429380 0.0005632517 FALSE TRUE
ENST00000486413 ENSG00000175662 HEK293_OSMI2_2hA HEK293_TMG_2hB TOM1L2 protein_coding retained_intron 10.40586 14.49526 6.108049 0.7455219 0.3864729 -1.245432 0.7038328 0.92409425 0.30480777 0.12837194 0.07306609 -1.569097 0.06384583 0.064766667 0.050400000 -0.01436667 0.75705164 0.0005632517   FALSE
ENST00000581396 ENSG00000175662 HEK293_OSMI2_2hA HEK293_TMG_2hB TOM1L2 protein_coding protein_coding 10.40586 14.49526 6.108049 0.7455219 0.3864729 -1.245432 0.4902000 1.55622537 0.03516943 0.55618838 0.03516943 -5.115801 0.03628750 0.108600000 0.006066667 -0.10253333 0.01620943 0.0005632517 FALSE TRUE
MSTRG.13777.5 ENSG00000175662 HEK293_OSMI2_2hA HEK293_TMG_2hB TOM1L2 protein_coding   10.40586 14.49526 6.108049 0.7455219 0.3864729 -1.245432 0.1506966 0.03328672 0.34124824 0.01943848 0.17176712 3.020495 0.02082500 0.002333333 0.059666667 0.05733333 0.20960245 0.0005632517 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000175662 E001 829.5316887 0.0056294042 0.0004492721 0.0019639858 17 17843511 17846824 3314 - 2.754 2.888 0.447
ENSG00000175662 E002 36.7296426 0.0022558133 0.6263079874 0.7422663034 17 17846825 17846848 24 - 1.519 1.516 -0.010
ENSG00000175662 E003 163.7133457 0.0005422444 0.0730161507 0.1483621210 17 17846849 17847333 485 - 2.085 2.174 0.296
ENSG00000175662 E004 44.2059934 0.0245128970 0.0810192030 0.1611376539 17 17847334 17847348 15 - 1.430 1.633 0.695
ENSG00000175662 E005 69.0154922 0.0045491962 0.0122136414 0.0340445484 17 17847349 17847445 97 - 1.641 1.821 0.609
ENSG00000175662 E006 49.1741471 0.0017874646 0.0112401695 0.0317387526 17 17847446 17847468 23 - 1.492 1.680 0.642
ENSG00000175662 E007 72.4210616 0.0032730923 0.1357982469 0.2422099352 17 17847469 17847551 83 - 1.719 1.831 0.378
ENSG00000175662 E008 41.1169093 0.0059261564 0.5720896174 0.6982596265 17 17847552 17847568 17 - 1.513 1.584 0.244
ENSG00000175662 E009 92.7480218 0.0013198969 0.4365125682 0.5785809493 17 17847569 17847783 215 - 1.862 1.926 0.215
ENSG00000175662 E010 49.0615273 0.0005513003 0.1206089148 0.2208315332 17 17848823 17848859 37 - 1.680 1.623 -0.192
ENSG00000175662 E011 1.1080838 0.3034056060 0.5910129856 0.7138219762 17 17848860 17848949 90 - 0.178 0.342 1.238
ENSG00000175662 E012 56.2747647 0.0004336136 0.0223491765 0.0564049935 17 17850893 17850952 60 - 1.756 1.668 -0.296
ENSG00000175662 E013 8.9333321 0.0066511937 0.8515470901 0.9079465867 17 17850953 17851303 351 - 0.936 0.940 0.013
ENSG00000175662 E014 3.7119861 0.0391093305 0.3647424422 0.5090754886 17 17857769 17857855 87 - 0.705 0.573 -0.570
ENSG00000175662 E015 62.5832633 0.0015011877 0.0175024553 0.0460500478 17 17861476 17861551 76 - 1.800 1.709 -0.308
ENSG00000175662 E016 3.6489621 0.1106866615 0.0028411823 0.0097980062 17 17861903 17862427 525 - 0.000 0.735 13.468
ENSG00000175662 E017 79.0161682 0.0018012727 0.4072119107 0.5508080570 17 17862731 17862848 118 - 1.843 1.834 -0.030
ENSG00000175662 E018 1.0223597 0.2147300960 0.6447966178 0.7570467030 17 17863274 17863410 137 - 0.179 0.309 1.029
ENSG00000175662 E019 77.2215789 0.0033433132 0.6035881281 0.7243585186 17 17866296 17866419 124 - 1.820 1.826 0.018
ENSG00000175662 E020 44.8091952 0.0186553739 0.5894851025 0.7125522993 17 17866876 17866924 49 - 1.603 1.591 -0.041
ENSG00000175662 E021 1.0747875 0.0712109123 0.4117163670 0.5552596288 17 17868965 17869339 375 - 0.403 0.261 -0.892
ENSG00000175662 E022 61.6353689 0.0108169294 0.3765144691 0.5208246258 17 17869340 17869473 134 - 1.755 1.724 -0.105
ENSG00000175662 E023 0.4031496 0.0243514493 0.6156193353 0.7338646394 17 17869474 17869914 441 - 0.000 0.151 10.483
ENSG00000175662 E024 0.1817044 0.0396854640 1.0000000000   17 17871965 17872064 100 - 0.000 0.082 9.434
ENSG00000175662 E025 64.8788704 0.0005084228 0.0010736987 0.0042135472 17 17879627 17879743 117 - 1.843 1.718 -0.423
ENSG00000175662 E026 61.0850524 0.0003876492 0.0001025917 0.0005340357 17 17882705 17882863 159 - 1.840 1.684 -0.529
ENSG00000175662 E027 73.7171061 0.0020554347 0.0003550949 0.0015998776 17 17884634 17884768 135 - 1.908 1.767 -0.475
ENSG00000175662 E028 38.7609252 0.0014335849 0.0330084311 0.0778210993 17 17893661 17893677 17 - 1.610 1.506 -0.354
ENSG00000175662 E029 73.2601358 0.0111927934 0.0143988786 0.0391321563 17 17893678 17893810 133 - 1.899 1.773 -0.427
ENSG00000175662 E030 40.9017360 0.0148811760 0.2872564809 0.4277461632 17 17898596 17898613 18 - 1.598 1.545 -0.181
ENSG00000175662 E031 58.6424898 0.0145741618 0.0376303592 0.0866374025 17 17898614 17898674 61 - 1.796 1.678 -0.401
ENSG00000175662 E032 61.9465317 0.0063230377 0.0225871858 0.0568935089 17 17907447 17907526 80 - 1.810 1.707 -0.351
ENSG00000175662 E033 31.6631228 0.0006692261 0.1700864218 0.2883097479 17 17907527 17907531 5 - 1.499 1.435 -0.220
ENSG00000175662 E034 59.9170979 0.0140415503 0.0792543903 0.1583224176 17 17972262 17972422 161 - 1.786 1.696 -0.303