ENSG00000175634

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000312629 ENSG00000175634 HEK293_OSMI2_2hA HEK293_TMG_2hB RPS6KB2 protein_coding protein_coding 104.9355 181.8568 65.09825 9.943719 1.38753 -1.48197 72.920265 138.506828 37.155429 4.8293372 2.3483099 -1.8980281 0.6602125 0.76350000 0.5703333 -0.1931667 0.0002230951 7.958055e-08 FALSE TRUE
ENST00000526268 ENSG00000175634 HEK293_OSMI2_2hA HEK293_TMG_2hB RPS6KB2 protein_coding retained_intron 104.9355 181.8568 65.09825 9.943719 1.38753 -1.48197 4.616871 5.174825 3.738842 0.8036646 0.8826281 -0.4678501 0.0530250 0.02820000 0.0569000 0.0287000 0.0943813121 7.958055e-08 FALSE FALSE
MSTRG.5819.1 ENSG00000175634 HEK293_OSMI2_2hA HEK293_TMG_2hB RPS6KB2 protein_coding   104.9355 181.8568 65.09825 9.943719 1.38753 -1.48197 8.880543 14.207129 6.596342 1.4099404 0.6634232 -1.1057066 0.0883750 0.07823333 0.1018333 0.0236000 0.4618310593 7.958055e-08 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000175634 E001 3.634492 5.177438e-03 5.368733e-01 6.685402e-01 11 67428442 67428459 18 + 0.664 0.561 -0.452
ENSG00000175634 E002 4.957768 5.973346e-03 7.190367e-02 1.465026e-01 11 67428460 67428462 3 + 0.882 0.620 -1.062
ENSG00000175634 E003 6.811878 2.462980e-03 3.154587e-04 1.442682e-03 11 67428463 67428464 2 + 1.115 0.672 -1.703
ENSG00000175634 E004 17.043355 1.306528e-03 1.433921e-04 7.182953e-04 11 67428465 67428482 18 + 1.399 1.063 -1.188
ENSG00000175634 E005 48.426514 9.562098e-04 4.717528e-05 2.674532e-04 11 67428483 67428493 11 + 1.769 1.537 -0.789
ENSG00000175634 E006 52.707564 1.238183e-03 2.682645e-05 1.614521e-04 11 67428494 67428497 4 + 1.808 1.575 -0.788
ENSG00000175634 E007 61.233189 4.211566e-04 6.568151e-06 4.551434e-05 11 67428498 67428503 6 + 1.865 1.638 -0.768
ENSG00000175634 E008 91.839328 2.091079e-03 5.673300e-10 8.805420e-09 11 67428504 67428504 1 + 2.075 1.794 -0.946
ENSG00000175634 E009 445.779022 1.899557e-03 9.479888e-03 2.748812e-02 11 67428505 67428623 119 + 2.606 2.532 -0.246
ENSG00000175634 E010 16.747262 2.168032e-02 3.962293e-10 6.323879e-09 11 67428624 67428753 130 + 1.584 0.917 -2.361
ENSG00000175634 E011 21.049278 1.925893e-03 3.188235e-18 1.649376e-16 11 67428754 67428912 159 + 1.675 1.007 -2.339
ENSG00000175634 E012 14.425319 1.192943e-03 7.309266e-15 2.458662e-13 11 67428913 67428981 69 + 1.533 0.844 -2.468
ENSG00000175634 E013 402.959848 1.139714e-03 4.469497e-01 5.883929e-01 11 67428982 67429022 41 + 2.520 2.500 -0.068
ENSG00000175634 E014 10.118569 1.805593e-03 6.743089e-09 8.583914e-08 11 67429023 67429119 97 + 1.355 0.760 -2.189
ENSG00000175634 E015 759.656146 1.223067e-04 5.812420e-02 1.234128e-01 11 67429120 67429240 121 + 2.801 2.770 -0.103
ENSG00000175634 E016 676.469428 1.123879e-04 8.051276e-02 1.603543e-01 11 67429527 67429595 69 + 2.751 2.721 -0.100
ENSG00000175634 E017 38.345806 3.504919e-03 1.102018e-17 5.384936e-16 11 67429596 67431367 1772 + 1.861 1.318 -1.856
ENSG00000175634 E018 1088.477278 5.123121e-04 1.316439e-01 2.364277e-01 11 67431368 67431515 148 + 2.954 2.930 -0.080
ENSG00000175634 E019 88.718959 1.163600e-02 1.021546e-14 3.355214e-13 11 67431516 67432239 724 + 2.194 1.696 -1.674
ENSG00000175634 E020 32.751381 1.172796e-02 3.478618e-07 3.176123e-06 11 67432240 67432352 113 + 1.717 1.306 -1.412
ENSG00000175634 E021 20.259247 9.463611e-04 2.071846e-06 1.606257e-05 11 67432353 67432355 3 + 1.501 1.119 -1.337
ENSG00000175634 E022 63.311179 4.337892e-03 3.510935e-09 4.703600e-08 11 67432356 67432492 137 + 1.949 1.616 -1.125
ENSG00000175634 E023 34.285959 4.409750e-03 3.524087e-07 3.213416e-06 11 67432493 67432599 107 + 1.702 1.346 -1.220
ENSG00000175634 E024 774.194528 1.132942e-03 6.516715e-01 7.624863e-01 11 67432600 67432657 58 + 2.794 2.785 -0.030
ENSG00000175634 E025 696.004010 1.008909e-03 4.930915e-01 6.301416e-01 11 67432737 67432775 39 + 2.753 2.738 -0.048
ENSG00000175634 E026 848.439934 8.538015e-04 1.321261e-01 2.370632e-01 11 67432776 67432837 62 + 2.850 2.821 -0.095
ENSG00000175634 E027 1124.900825 7.934723e-05 8.650116e-03 2.540916e-02 11 67432952 67433042 91 + 2.975 2.941 -0.115
ENSG00000175634 E028 22.715210 1.415246e-02 9.760386e-05 5.107944e-04 11 67433043 67433125 83 + 1.541 1.175 -1.273
ENSG00000175634 E029 921.181226 8.131113e-05 8.058260e-01 8.765528e-01 11 67433126 67433194 69 + 2.859 2.861 0.009
ENSG00000175634 E030 634.553452 1.017554e-04 4.438775e-01 5.854592e-01 11 67433195 67433216 22 + 2.689 2.702 0.042
ENSG00000175634 E031 44.576966 1.452143e-02 1.602765e-03 5.970094e-03 11 67433217 67433339 123 + 1.751 1.492 -0.884
ENSG00000175634 E032 1155.126389 2.340332e-04 8.102560e-02 1.611465e-01 11 67433340 67433443 104 + 2.939 2.964 0.083
ENSG00000175634 E033 517.663090 1.294428e-04 2.737578e-05 1.643978e-04 11 67433444 67433447 4 + 2.541 2.625 0.280
ENSG00000175634 E034 874.570720 1.237972e-04 7.052035e-06 4.853016e-05 11 67433995 67434057 63 + 2.781 2.851 0.231
ENSG00000175634 E035 17.683090 2.303901e-03 2.748715e-04 1.277472e-03 11 67434058 67434197 140 + 1.410 1.089 -1.131
ENSG00000175634 E036 976.266851 1.108414e-03 2.703809e-02 6.607440e-02 11 67434198 67434275 78 + 2.849 2.896 0.156
ENSG00000175634 E037 1235.465927 2.322779e-03 1.149819e-02 3.234439e-02 11 67434377 67434484 108 + 2.936 3.002 0.219
ENSG00000175634 E038 24.838758 6.870130e-03 6.797926e-06 4.696228e-05 11 67434485 67434581 97 + 1.577 1.209 -1.274
ENSG00000175634 E039 1019.237611 3.875707e-04 6.299854e-19 3.556283e-17 11 67434582 67434694 113 + 2.779 2.931 0.505
ENSG00000175634 E040 58.403589 7.854022e-04 7.303953e-07 6.248417e-06 11 67434695 67434988 294 + 1.865 1.609 -0.867
ENSG00000175634 E041 1152.385742 1.024788e-04 1.542333e-32 3.128377e-30 11 67434989 67435402 414 + 2.817 2.985 0.560