ENSG00000175611

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000412446 ENSG00000175611 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC00476 lncRNA lncRNA 4.198604 4.25992 4.210174 0.440021 0.1027321 -0.01690634 0.5050830 0.32546289 0.7276760 0.05294404 0.14704623 1.1368342 0.11966250 0.07930000 0.17273333 0.093433333 0.115569309 0.002237174   FALSE
ENST00000427259 ENSG00000175611 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC00476 lncRNA lncRNA 4.198604 4.25992 4.210174 0.440021 0.1027321 -0.01690634 0.1801434 0.00000000 0.3458976 0.00000000 0.17436068 5.1533905 0.03990000 0.00000000 0.08093333 0.080933333 0.177743899 0.002237174 TRUE FALSE
ENST00000448465 ENSG00000175611 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC00476 lncRNA lncRNA 4.198604 4.25992 4.210174 0.440021 0.1027321 -0.01690634 0.1519408 0.36505751 0.1153355 0.19229320 0.11533545 -1.5813173 0.03594167 0.08330000 0.02843333 -0.054866667 0.593588893 0.002237174   FALSE
ENST00000670189 ENSG00000175611 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC00476 lncRNA lncRNA 4.198604 4.25992 4.210174 0.440021 0.1027321 -0.01690634 0.3885391 0.52015829 0.2345782 0.26844537 0.11732139 -1.1161272 0.09644583 0.12470000 0.05706667 -0.067633333 0.881031666 0.002237174   FALSE
ENST00000671508 ENSG00000175611 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC00476 lncRNA lncRNA 4.198604 4.25992 4.210174 0.440021 0.1027321 -0.01690634 0.2208370 0.12054120 0.1516153 0.05236154 0.05080791 0.3080590 0.05102083 0.02900000 0.03543333 0.006433333 0.869033480 0.002237174 TRUE FALSE
ENST00000691767 ENSG00000175611 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC00476 lncRNA lncRNA 4.198604 4.25992 4.210174 0.440021 0.1027321 -0.01690634 1.0943712 1.61693492 0.3241938 0.25951721 0.32419383 -2.2833995 0.27232083 0.38520000 0.07360000 -0.311600000 0.088954633 0.002237174   FALSE
MSTRG.33060.19 ENSG00000175611 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC00476 lncRNA   4.198604 4.25992 4.210174 0.440021 0.1027321 -0.01690634 0.2790562 0.66233304 0.4996491 0.22067374 0.34635689 -0.3996719 0.06576250 0.15300000 0.12243333 -0.030566667 0.780313926 0.002237174   FALSE
MSTRG.33060.5 ENSG00000175611 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC00476 lncRNA   4.198604 4.25992 4.210174 0.440021 0.1027321 -0.01690634 0.3519351 0.07350695 0.8429979 0.03696469 0.20332916 3.3525740 0.07935833 0.01916667 0.20273333 0.183566667 0.002237174 0.002237174   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000175611 E001 0.7437457 0.0156719455 1.338720e-01 2.395320e-01 9 95759231 95759524 294 - 0.382 0.114 -2.231
ENSG00000175611 E002 0.1515154 0.0433325045 4.490249e-01   9 95759722 95759836 115 - 0.131 0.000 -11.296
ENSG00000175611 E003 0.1451727 0.0435883413 4.493405e-01   9 95773888 95774017 130 - 0.131 0.000 -11.295
ENSG00000175611 E004 7.0345505 0.0860979638 1.364647e-02 3.741961e-02 9 95813170 95813321 152 - 1.101 0.642 -1.778
ENSG00000175611 E005 5.0500541 0.0041374733 1.183061e-01 2.175107e-01 9 95813322 95813589 268 - 0.886 0.664 -0.891
ENSG00000175611 E006 1.3767742 0.0116679062 2.409976e-01 3.753423e-01 9 95813590 95813594 5 - 0.493 0.279 -1.232
ENSG00000175611 E007 3.3749103 0.0050217334 4.686432e-02 1.035890e-01 9 95813595 95813598 4 - 0.798 0.492 -1.331
ENSG00000175611 E008 9.2922439 0.0037757177 8.636369e-06 5.822414e-05 9 95813599 95813768 170 - 1.236 0.740 -1.849
ENSG00000175611 E009 10.2304801 0.0337226184 3.154481e-04 1.442682e-03 9 95813769 95813922 154 - 1.271 0.781 -1.807
ENSG00000175611 E010 0.1472490 0.0454976262 4.484694e-01   9 95840600 95840614 15 - 0.131 0.000 -11.289
ENSG00000175611 E011 1.2209923 0.0109982238 3.828630e-01 5.270358e-01 9 95840615 95842750 2136 - 0.441 0.279 -0.968
ENSG00000175611 E012 2.4554227 0.0501037110 4.037312e-01 5.475112e-01 9 95850227 95850292 66 - 0.620 0.449 -0.804
ENSG00000175611 E013 1.1908008 0.0529110801 3.516714e-01 4.959030e-01 9 95851824 95852029 206 - 0.232 0.398 1.089
ENSG00000175611 E014 1.9759755 0.3662629485 3.364196e-02 7.904201e-02 9 95869052 95869839 788 - 0.716 0.117 -3.770
ENSG00000175611 E015 1.5405712 0.0287953688 5.743030e-03 1.793603e-02 9 95869840 95870087 248 - 0.620 0.114 -3.395
ENSG00000175611 E016 1.1395084 0.0120088892 1.983922e-01 3.241987e-01 9 95870088 95870246 159 - 0.441 0.205 -1.550
ENSG00000175611 E017 0.9943357 0.0135874679 3.412657e-01 4.851842e-01 9 95870247 95870282 36 - 0.382 0.205 -1.228
ENSG00000175611 E018 0.4804688 0.0217714608 5.065654e-01 6.422186e-01 9 95870283 95870283 1 - 0.232 0.114 -1.229
ENSG00000175611 E019 0.6287620 0.0172671820 9.052981e-01 9.436992e-01 9 95870284 95870310 27 - 0.232 0.204 -0.231
ENSG00000175611 E020 1.4360062 0.0528004530 4.440341e-01 5.856045e-01 9 95870311 95870318 8 - 0.313 0.446 0.760
ENSG00000175611 E021 19.5077607 0.0015546676 2.318899e-04 1.099481e-03 9 95870319 95870441 123 - 1.136 1.408 0.956
ENSG00000175611 E022 1.6262051 0.0119944981 8.470996e-01 9.050386e-01 9 95874509 95874548 40 - 0.441 0.398 -0.230
ENSG00000175611 E023 0.1515154 0.0433325045 4.490249e-01   9 95874549 95874622 74 - 0.131 0.000 -11.296
ENSG00000175611 E024 2.1401989 0.0068347561 6.307664e-01 7.458947e-01 9 95874623 95874979 357 - 0.540 0.448 -0.451
ENSG00000175611 E025 51.3279877 0.0004875771 1.819892e-03 6.663055e-03 9 95874980 95875096 117 - 1.643 1.766 0.416
ENSG00000175611 E026 31.8563934 0.0008021709 3.079757e-01 4.502074e-01 9 95875097 95875147 51 - 1.486 1.528 0.146
ENSG00000175611 E027 17.9869583 0.0010876096 8.886553e-01 9.328177e-01 9 95875148 95875154 7 - 1.278 1.272 -0.020
ENSG00000175611 E028 18.2053993 0.0011433844 5.231476e-01 6.568955e-01 9 95875155 95875225 71 - 1.317 1.251 -0.230
ENSG00000175611 E029 58.4031821 0.0006160762 6.478341e-02 1.346893e-01 9 95875226 95875864 639 - 1.737 1.796 0.201
ENSG00000175611 E030 9.4276923 0.0021609415 1.685292e-04 8.288963e-04 9 95875865 95876136 272 - 0.747 1.152 1.527