ENSG00000175595

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000311895 ENSG00000175595 HEK293_OSMI2_2hA HEK293_TMG_2hB ERCC4 protein_coding protein_coding 4.95035 1.564259 7.326221 0.1381715 0.3272213 2.220364 2.6180542 0.60208040 4.27917804 0.10717470 0.28101152 2.8089081 0.4369750 0.40166667 0.584100000 0.18243333 3.058730e-01 3.634611e-05 FALSE TRUE
ENST00000462862 ENSG00000175595 HEK293_OSMI2_2hA HEK293_TMG_2hB ERCC4 protein_coding nonsense_mediated_decay 4.95035 1.564259 7.326221 0.1381715 0.3272213 2.220364 0.2133798 0.55457567 0.04513185 0.17488908 0.04513185 -3.3562090 0.1235333 0.34136667 0.006333333 -0.33503333 3.634611e-05 3.634611e-05 FALSE TRUE
ENST00000574781 ENSG00000175595 HEK293_OSMI2_2hA HEK293_TMG_2hB ERCC4 protein_coding processed_transcript 4.95035 1.564259 7.326221 0.1381715 0.3272213 2.220364 0.3154511 0.02873072 0.71520878 0.02873072 0.04798078 4.2268463 0.0575750 0.02023333 0.098200000 0.07796667 2.405204e-02 3.634611e-05 FALSE FALSE
ENST00000682617 ENSG00000175595 HEK293_OSMI2_2hA HEK293_TMG_2hB ERCC4 protein_coding protein_coding 4.95035 1.564259 7.326221 0.1381715 0.3272213 2.220364 0.2795499 0.02235143 0.63803005 0.02235143 0.12370833 4.3241593 0.0535250 0.01560000 0.088733333 0.07313333 7.235340e-02 3.634611e-05 FALSE TRUE
ENST00000683407 ENSG00000175595 HEK293_OSMI2_2hA HEK293_TMG_2hB ERCC4 protein_coding retained_intron 4.95035 1.564259 7.326221 0.1381715 0.3272213 2.220364 0.6820921 0.27400101 0.42935781 0.05788845 0.11452785 0.6295003 0.1555375 0.17203333 0.058333333 -0.11370000 2.903981e-02 3.634611e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000175595 E001 0.4502799 0.0336203223 7.231671e-01 8.170593e-01 16 13920138 13920153 16 + 0.153 0.000 -9.626
ENSG00000175595 E002 0.4502799 0.0336203223 7.231671e-01 8.170593e-01 16 13920154 13920156 3 + 0.153 0.000 -11.321
ENSG00000175595 E003 0.5975289 0.0309013194 4.954116e-01 6.322235e-01 16 13920157 13920157 1 + 0.194 0.000 -11.705
ENSG00000175595 E004 2.4086607 0.0120832721 1.611455e-01 2.765992e-01 16 13920158 13920177 20 + 0.382 0.678 1.418
ENSG00000175595 E005 2.5601761 0.0189933164 2.125758e-01 3.415849e-01 16 13920178 13920178 1 + 0.406 0.678 1.280
ENSG00000175595 E006 5.0408454 0.0984108309 3.844197e-01 5.285683e-01 16 13920179 13920190 12 + 0.642 0.848 0.837
ENSG00000175595 E007 18.2643684 0.0414263540 2.832993e-01 4.233801e-01 16 13920191 13920372 182 + 1.195 1.094 -0.360
ENSG00000175595 E008 1.0329332 0.1460277998 2.584221e-01 3.956721e-01 16 13920373 13920427 55 + 0.298 0.000 -12.076
ENSG00000175595 E009 1.6252627 0.0152808506 8.655921e-01 9.174228e-01 16 13920428 13920564 137 + 0.328 0.399 0.421
ENSG00000175595 E010 7.4816001 0.0079649870 2.953842e-01 4.365198e-01 16 13920565 13922030 1466 + 0.848 0.742 -0.422
ENSG00000175595 E011 28.5336886 0.0007290375 1.979199e-02 5.104601e-02 16 13922031 13922211 181 + 1.384 1.244 -0.489
ENSG00000175595 E012 0.4460135 0.0299770825 7.235328e-01 8.173347e-01 16 13924530 13924637 108 + 0.153 0.000 -11.341
ENSG00000175595 E013 2.7261777 0.0062061038 4.276800e-01 5.705220e-01 16 13924638 13926153 1516 + 0.512 0.399 -0.582
ENSG00000175595 E014 2.8119015 0.0066183864 4.284501e-01 5.712128e-01 16 13926154 13926291 138 + 0.512 0.399 -0.581
ENSG00000175595 E015 1.0330470 0.0118593871 2.029890e-01 3.299640e-01 16 13926292 13926551 260 + 0.298 0.000 -12.493
ENSG00000175595 E016 0.7363589 0.0154722958 3.582113e-01 5.025789e-01 16 13926552 13926560 9 + 0.231 0.000 -12.070
ENSG00000175595 E017 31.5790392 0.0006160171 8.390695e-02 1.656610e-01 16 13926561 13926756 196 + 1.418 1.344 -0.259
ENSG00000175595 E018 0.6653823 0.0171182229 7.120281e-01 8.088748e-01 16 13926757 13926801 45 + 0.153 0.244 0.834
ENSG00000175595 E019 1.1792638 0.0126381623 6.848023e-01 7.876973e-01 16 13927450 13927655 206 + 0.298 0.243 -0.391
ENSG00000175595 E020 1.6919729 0.0759755376 4.586890e-01 5.989940e-01 16 13927973 13928027 55 + 0.381 0.245 -0.895
ENSG00000175595 E021 22.3784745 0.0066694596 5.752376e-03 1.796137e-02 16 13928028 13928121 94 + 1.301 1.061 -0.853
ENSG00000175595 E022 24.6596088 0.0019493377 1.313067e-02 3.621122e-02 16 13928122 13928235 114 + 1.336 1.162 -0.613
ENSG00000175595 E023 0.0000000       16 13928544 13928691 148 +      
ENSG00000175595 E024 31.8006022 0.0006135698 1.552719e-02 4.168729e-02 16 13930710 13930890 181 + 1.432 1.297 -0.470
ENSG00000175595 E025 0.1515154 0.0433676069 1.000000e+00   16 13932026 13932156 131 + 0.057 0.000 -9.789
ENSG00000175595 E026 25.6534255 0.0007683658 8.774163e-02 1.717100e-01 16 13932157 13932285 129 + 1.334 1.244 -0.313
ENSG00000175595 E027 0.1451727 0.0431762532 1.000000e+00   16 13932286 13932404 119 + 0.057 0.000 -9.790
ENSG00000175595 E028 0.7300161 0.0432473115 3.688995e-01 5.133156e-01 16 13932405 13933247 843 + 0.231 0.000 -11.926
ENSG00000175595 E029 0.4375944 0.0251364425 7.252769e-01 8.185972e-01 16 13934022 13934191 170 + 0.153 0.000 -11.369
ENSG00000175595 E030 24.6682483 0.0051028348 7.445822e-02 1.506653e-01 16 13934192 13934302 111 + 1.319 1.206 -0.396
ENSG00000175595 E031 0.1472490 0.0432249438 1.000000e+00   16 13934303 13934355 53 + 0.057 0.000 -9.790
ENSG00000175595 E032 72.6747919 0.0021598752 8.944987e-04 3.594597e-03 16 13935146 13935743 598 + 1.778 1.650 -0.433
ENSG00000175595 E033 11.0133967 0.0215717308 8.438196e-08 8.690828e-07 16 13935744 13936727 984 + 0.751 1.444 2.530
ENSG00000175595 E034 0.1472490 0.0432249438 1.000000e+00   16 13937764 13937765 2 + 0.057 0.000 -9.790
ENSG00000175595 E035 21.4678834 0.0009109968 9.487234e-02 1.826980e-01 16 13937766 13937858 93 + 1.263 1.163 -0.355
ENSG00000175595 E036 5.2165403 0.0031720767 1.167571e-01 2.153357e-01 16 13937859 13940361 2503 + 0.741 0.513 -0.998
ENSG00000175595 E037 0.8815316 0.0136968632 2.676270e-01 4.059468e-01 16 13943974 13944095 122 + 0.266 0.000 -12.301
ENSG00000175595 E038 22.1800840 0.0008907919 7.834207e-03 2.336585e-02 16 13944723 13944835 113 + 1.295 1.089 -0.731
ENSG00000175595 E039 353.0171299 0.0056887814 1.876772e-08 2.199906e-07 16 13947614 13952348 4735 + 2.395 2.595 0.665