ENSG00000175582

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000310653 ENSG00000175582 HEK293_OSMI2_2hA HEK293_TMG_2hB RAB6A protein_coding protein_coding 29.81935 17.02347 46.39664 1.043213 2.048842 1.445959 14.27872 10.985739 20.555622 0.7269125 0.3492251 0.9032901 0.52987917 0.6450667 0.4441000 -0.20096667 2.023051e-10 5.70325e-26 FALSE TRUE
ENST00000336083 ENSG00000175582 HEK293_OSMI2_2hA HEK293_TMG_2hB RAB6A protein_coding protein_coding 29.81935 17.02347 46.39664 1.043213 2.048842 1.445959 10.62885 5.898247 16.700297 0.3248288 1.1568180 1.4999353 0.35822500 0.3469333 0.3598667 0.01293333 8.901519e-01 5.70325e-26 FALSE TRUE
ENST00000541973 ENSG00000175582 HEK293_OSMI2_2hA HEK293_TMG_2hB RAB6A protein_coding protein_coding 29.81935 17.02347 46.39664 1.043213 2.048842 1.445959 4.38738 0.000000 8.346367 0.0000000 1.2065894 9.7067321 0.09714583 0.0000000 0.1789000 0.17890000 5.703250e-26 5.70325e-26 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000175582 E001 1270.8982682 0.0034550180 8.416483e-17 3.657897e-15 11 73675638 73677398 1761 - 2.981 3.223 0.805
ENSG00000175582 E002 261.4798301 0.0006815772 2.168666e-01 3.466305e-01 11 73677399 73677590 192 - 2.354 2.448 0.312
ENSG00000175582 E003 314.3991962 0.0011497696 3.069481e-01 4.491262e-01 11 73677591 73677893 303 - 2.454 2.489 0.118
ENSG00000175582 E004 121.3326788 0.0002463887 3.230543e-01 4.663932e-01 11 73677894 73677907 14 - 2.044 2.072 0.096
ENSG00000175582 E005 148.3384891 0.0002317136 8.479383e-01 9.055768e-01 11 73677908 73677943 36 - 2.118 2.187 0.230
ENSG00000175582 E006 122.8517100 0.0003271027 8.163324e-01 8.837898e-01 11 73677944 73677962 19 - 2.037 2.108 0.236
ENSG00000175582 E007 172.1902568 0.0001936944 1.867367e-01 3.096391e-01 11 73679654 73679685 32 - 2.198 2.223 0.084
ENSG00000175582 E008 181.1727708 0.0002448907 8.126622e-02 1.615323e-01 11 73679686 73679720 35 - 2.222 2.235 0.045
ENSG00000175582 E009 0.2214452 0.0394745750 2.077053e-01   11 73704164 73704215 52 - 0.000 0.186 10.486
ENSG00000175582 E010 260.0106104 0.0004618078 8.517990e-04 3.444193e-03 11 73707420 73707513 94 - 2.388 2.367 -0.071
ENSG00000175582 E011 251.1555549 0.0002062412 1.028621e-12 2.520947e-11 11 73716251 73716362 112 - 2.401 2.285 -0.388
ENSG00000175582 E012 89.4371000 0.0006231130 2.057425e-07 1.967358e-06 11 73718613 73718718 106 - 1.966 1.802 -0.554
ENSG00000175582 E013 147.1091587 0.0004552950 2.015958e-06 1.567118e-05 11 73718785 73718890 106 - 2.164 2.069 -0.321
ENSG00000175582 E014 191.0425748 0.0016857137 7.169257e-09 9.072774e-08 11 73720846 73720899 54 - 2.288 2.150 -0.461
ENSG00000175582 E015 0.2966881 0.0268934412 5.481107e-01   11 73729464 73730764 1301 - 0.145 0.000 -8.919
ENSG00000175582 E016 184.6516104 0.0010037213 3.498534e-08 3.886721e-07 11 73730765 73730823 59 - 2.268 2.153 -0.386
ENSG00000175582 E017 0.0000000       11 73760048 73760095 48 -      
ENSG00000175582 E018 305.8316668 0.0017821588 1.756866e-11 3.511637e-10 11 73760566 73761137 572 - 2.491 2.353 -0.461