ENSG00000175471

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000429576 ENSG00000175471 HEK293_OSMI2_2hA HEK293_TMG_2hB MCTP1 protein_coding protein_coding 0.4219476 0.2210324 0.7326168 0.0204322 0.06830786 1.684522 0.027466636 0.04893513 0.01849233 0.027358236 0.01849233 -1.0485543 0.07692083 0.2472667 0.02840000 -0.218866667 0.225967196 0.008090393 FALSE TRUE
ENST00000503301 ENSG00000175471 HEK293_OSMI2_2hA HEK293_TMG_2hB MCTP1 protein_coding protein_coding 0.4219476 0.2210324 0.7326168 0.0204322 0.06830786 1.684522 0.034810232 0.02258811 0.08991994 0.022588109 0.04800992 1.6164270 0.12308750 0.1063000 0.11493333 0.008633333 0.941238556 0.008090393 FALSE FALSE
ENST00000505078 ENSG00000175471 HEK293_OSMI2_2hA HEK293_TMG_2hB MCTP1 protein_coding protein_coding 0.4219476 0.2210324 0.7326168 0.0204322 0.06830786 1.684522 0.056892189 0.04656504 0.20749514 0.046565035 0.02543492 1.9430007 0.11997500 0.1791667 0.28280000 0.103633333 0.662520698 0.008090393 FALSE TRUE
ENST00000506568 ENSG00000175471 HEK293_OSMI2_2hA HEK293_TMG_2hB MCTP1 protein_coding protein_coding 0.4219476 0.2210324 0.7326168 0.0204322 0.06830786 1.684522 0.021917596 0.03057453 0.02017291 0.004582973 0.02017291 -0.4273205 0.05802083 0.1381667 0.02973333 -0.108433333 0.302989568 0.008090393 FALSE TRUE
ENST00000507214 ENSG00000175471 HEK293_OSMI2_2hA HEK293_TMG_2hB MCTP1 protein_coding protein_coding 0.4219476 0.2210324 0.7326168 0.0204322 0.06830786 1.684522 0.107434733 0.00000000 0.25759994 0.000000000 0.04793949 4.7420059 0.13600000 0.0000000 0.35193333 0.351933333 0.008090393 0.008090393 FALSE FALSE
ENST00000508509 ENSG00000175471 HEK293_OSMI2_2hA HEK293_TMG_2hB MCTP1 protein_coding protein_coding 0.4219476 0.2210324 0.7326168 0.0204322 0.06830786 1.684522 0.026244892 0.00000000 0.00000000 0.000000000 0.00000000 0.0000000 0.06876250 0.0000000 0.00000000 0.000000000   0.008090393 FALSE TRUE
ENST00000512425 ENSG00000175471 HEK293_OSMI2_2hA HEK293_TMG_2hB MCTP1 protein_coding protein_coding 0.4219476 0.2210324 0.7326168 0.0204322 0.06830786 1.684522 0.004822441 0.00000000 0.03857953 0.000000000 0.03857953 2.2803484 0.00711250 0.0000000 0.05690000 0.056900000 1.000000000 0.008090393 FALSE TRUE
ENST00000512568 ENSG00000175471 HEK293_OSMI2_2hA HEK293_TMG_2hB MCTP1 protein_coding processed_transcript 0.4219476 0.2210324 0.7326168 0.0204322 0.06830786 1.684522 0.019527176 0.00000000 0.00000000 0.000000000 0.00000000 0.0000000 0.06006250 0.0000000 0.00000000 0.000000000   0.008090393 FALSE FALSE
ENST00000515393 ENSG00000175471 HEK293_OSMI2_2hA HEK293_TMG_2hB MCTP1 protein_coding protein_coding 0.4219476 0.2210324 0.7326168 0.0204322 0.06830786 1.684522 0.070441910 0.06350638 0.06906966 0.005629609 0.01000250 0.1052547 0.21150833 0.2950333 0.09480000 -0.200233333 0.172612153 0.008090393 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000175471 E001 0.1817044 0.042109024 0.31245390   5 94703690 94703740 51 - 0.000 0.148 11.073
ENSG00000175471 E002 2.9379667 0.061704118 0.39483006 0.53865975 5 94703741 94705203 1463 - 0.525 0.667 0.630
ENSG00000175471 E003 3.0590908 0.005430310 0.21738524 0.34723850 5 94705204 94706578 1375 - 0.526 0.703 0.778
ENSG00000175471 E004 0.3729606 0.028161454 0.73595376 0.82658994 5 94706579 94706590 12 - 0.101 0.148 0.630
ENSG00000175471 E005 4.1029373 0.004610132 0.08498893 0.16738813 5 94706591 94707495 905 - 0.795 0.535 -1.109
ENSG00000175471 E006 1.0393897 0.012198908 0.01702442 0.04498849 5 94707496 94707524 29 - 0.452 0.000 -12.911
ENSG00000175471 E007 1.2898780 0.010675817 0.94664117 0.97049277 5 94707525 94707567 43 - 0.363 0.345 -0.109
ENSG00000175471 E008 1.5133995 0.012124658 0.71936360 0.81423446 5 94708512 94708548 37 - 0.363 0.418 0.307
ENSG00000175471 E009 1.9551466 0.019691209 0.73487202 0.82572745 5 94708549 94708609 61 - 0.491 0.418 -0.370
ENSG00000175471 E010 0.4439371 0.022122346 0.18108438 0.30257447 5 94708610 94710693 2084 - 0.252 0.000 -11.688
ENSG00000175471 E011 2.5451988 0.009735089 0.67666418 0.78158220 5 94710818 94710927 110 - 0.526 0.583 0.264
ENSG00000175471 E012 1.9142718 0.198666583 0.22347102 0.35453057 5 94714777 94714886 110 - 0.363 0.577 1.087
ENSG00000175471 E013 2.0616346 0.007522251 0.27221623 0.41107137 5 94779110 94779163 54 - 0.410 0.583 0.848
ENSG00000175471 E014 0.0000000       5 94784828 94784897 70 -      
ENSG00000175471 E015 1.3284874 0.011842500 0.73291350 0.82426741 5 94799013 94799084 72 - 0.410 0.345 -0.376
ENSG00000175471 E016 1.2898780 0.010675817 0.94664117 0.97049277 5 94799085 94799132 48 - 0.363 0.345 -0.109
ENSG00000175471 E017 0.0000000       5 94867143 94867221 79 -      
ENSG00000175471 E018 0.3332198 0.029478338 0.73637171   5 94867222 94867382 161 - 0.101 0.148 0.627
ENSG00000175471 E019 0.4815130 0.022564473 0.33533724 0.47911787 5 94867383 94868332 950 - 0.101 0.257 1.625
ENSG00000175471 E020 2.7573051 0.006296540 0.05401057 0.11628356 5 94868333 94868452 120 - 0.410 0.703 1.366
ENSG00000175471 E021 2.4983978 0.220312480 0.56961720 0.69615429 5 94870417 94870491 75 - 0.490 0.589 0.466
ENSG00000175471 E022 2.9914372 0.027251286 0.18142804 0.30303643 5 94870872 94870973 102 - 0.491 0.703 0.949
ENSG00000175471 E023 2.6215970 0.008970740 0.05804516 0.12328861 5 94871315 94871417 103 - 0.410 0.702 1.363
ENSG00000175471 E024 2.3637219 0.111573851 0.99607428 1.00000000 5 94873139 94873241 103 - 0.526 0.532 0.031
ENSG00000175471 E025 1.5543008 0.009191937 0.20201475 0.32871599 5 94888879 94888972 94 - 0.491 0.257 -1.373
ENSG00000175471 E026 2.3208486 0.007243862 0.11794354 0.21698518 5 94894649 94894835 187 - 0.617 0.345 -1.372
ENSG00000175471 E027 2.0692119 0.009287685 0.54597537 0.67622974 5 94909251 94909315 65 - 0.526 0.418 -0.542
ENSG00000175471 E028 1.9542281 0.007966216 0.83749315 0.89841182 5 94909316 94909381 66 - 0.452 0.480 0.142
ENSG00000175471 E029 2.3064761 0.172345182 0.70607909 0.80430378 5 94912806 94912857 52 - 0.492 0.537 0.214
ENSG00000175471 E030 3.2716696 0.069235970 0.22179649 0.35253490 5 94912858 94912976 119 - 0.716 0.480 -1.057
ENSG00000175471 E031 0.4502799 0.031866206 0.18321590 0.30523416 5 94917896 94917973 78 - 0.252 0.000 -11.689
ENSG00000175471 E032 0.4804688 0.022685164 0.86581117 0.91758829 5 94923962 94924021 60 - 0.183 0.148 -0.373
ENSG00000175471 E033 0.0000000       5 94929628 94929701 74 -      
ENSG00000175471 E034 0.2214452 0.039889477 0.31200848   5 94930743 94931952 1210 - 0.000 0.148 11.087
ENSG00000175471 E035 0.5943067 0.019820822 0.57029943 0.69680252 5 94931953 94931991 39 - 0.252 0.147 -0.960
ENSG00000175471 E036 2.3260585 0.008116304 0.32766779 0.47114120 5 94940084 94940195 112 - 0.589 0.418 -0.833
ENSG00000175471 E037 0.7728905 0.015493027 0.37478083 0.51922266 5 94942348 94942349 2 - 0.311 0.148 -1.373
ENSG00000175471 E038 1.0694769 0.012192479 0.82686277 0.89108595 5 94942350 94942384 35 - 0.311 0.345 0.210
ENSG00000175471 E039 0.7727888 0.017267182 0.34088478 0.48481363 5 94942385 94942393 9 - 0.183 0.345 1.210
ENSG00000175471 E040 1.2188023 0.014116016 0.94735555 0.97092576 5 94942394 94942427 34 - 0.363 0.345 -0.112
ENSG00000175471 E041 1.3274433 0.011282107 0.29214666 0.43309137 5 94953219 94953292 74 - 0.452 0.257 -1.182
ENSG00000175471 E042 1.5436030 0.009736057 0.93492254 0.96303936 5 94953293 94953319 27 - 0.410 0.418 0.041
ENSG00000175471 E043 1.3889671 0.040972846 0.75748052 0.84230849 5 94953320 94953361 42 - 0.410 0.345 -0.373
ENSG00000175471 E044 0.0000000       5 94976745 94976809 65 -      
ENSG00000175471 E045 0.0000000       5 94978984 94979066 83 -      
ENSG00000175471 E046 1.6093681 0.103912862 0.66571301 0.77335386 5 95017367 95017484 118 - 0.452 0.347 -0.579
ENSG00000175471 E047 0.0000000       5 95017485 95017487 3 -      
ENSG00000175471 E048 0.0000000       5 95038069 95038187 119 -      
ENSG00000175471 E049 0.0000000       5 95068785 95068829 45 -      
ENSG00000175471 E050 0.0000000       5 95081426 95081637 212 -      
ENSG00000175471 E051 0.0000000       5 95081638 95081646 9 -      
ENSG00000175471 E052 0.0000000       5 95081801 95081884 84 -      
ENSG00000175471 E053 0.0000000       5 95154242 95154274 33 -      
ENSG00000175471 E054 0.0000000       5 95166123 95166175 53 -      
ENSG00000175471 E055 3.4707638 0.010414131 0.51366086 0.64844078 5 95283856 95285094 1239 - 0.693 0.583 -0.473