ENSG00000175470

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000482010 ENSG00000175470 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP2R2D protein_coding nonsense_mediated_decay 30.47696 27.3881 36.33772 1.775898 0.6419073 0.4077887 7.036370 8.8249426 5.995981 1.3884535 1.1586575 -0.5568209 0.23648750 0.32110000 0.16476667 -0.15633333 0.08042795 0.0114547 FALSE TRUE
ENST00000490777 ENSG00000175470 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP2R2D protein_coding retained_intron 30.47696 27.3881 36.33772 1.775898 0.6419073 0.4077887 7.628790 8.5752865 8.442585 1.0898239 0.7116901 -0.0224736 0.25088333 0.31186667 0.23263333 -0.07923333 0.24783120 0.0114547 FALSE TRUE
MSTRG.4826.20 ENSG00000175470 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP2R2D protein_coding   30.47696 27.3881 36.33772 1.775898 0.6419073 0.4077887 5.754090 3.1612641 6.539653 0.6329656 0.6740270 1.0463603 0.18365417 0.11486667 0.17940000 0.06453333 0.22784071 0.0114547 FALSE TRUE
MSTRG.4826.5 ENSG00000175470 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP2R2D protein_coding   30.47696 27.3881 36.33772 1.775898 0.6419073 0.4077887 1.529139 1.1791039 2.791904 0.5896262 1.4335023 1.2365325 0.05021250 0.04243333 0.07813333 0.03570000 0.94199545 0.0114547 TRUE TRUE
MSTRG.4826.6 ENSG00000175470 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP2R2D protein_coding   30.47696 27.3881 36.33772 1.775898 0.6419073 0.4077887 1.895754 0.3575004 4.711825 0.2045314 0.1011077 3.6835269 0.05380417 0.01303333 0.12980000 0.11676667 0.01145470 0.0114547 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000175470 E001 3.9535008 0.0040373650 2.654836e-04 1.239222e-03 10 131900972 131901005 34 + 0.885 0.321 -2.607
ENSG00000175470 E002 3.4009121 0.0052988647 1.246242e-05 8.100764e-05 10 131901006 131901007 2 + 0.868 0.135 -4.129
ENSG00000175470 E003 10.3331353 0.0238377634 2.434546e-13 6.552314e-12 10 131901008 131901030 23 + 1.322 0.135 -5.778
ENSG00000175470 E004 13.1010295 0.0267065583 6.843617e-13 1.724990e-11 10 131901031 131901044 14 + 1.409 0.321 -4.491
ENSG00000175470 E005 16.0894531 0.0130914132 2.282766e-17 1.062302e-15 10 131901045 131901048 4 + 1.494 0.391 -4.368
ENSG00000175470 E006 17.4063890 0.0199545557 1.011276e-16 4.349222e-15 10 131901049 131901063 15 + 1.528 0.391 -4.486
ENSG00000175470 E007 19.3231681 0.0102102208 1.838378e-18 9.799528e-17 10 131901064 131901073 10 + 1.561 0.551 -3.789
ENSG00000175470 E008 43.1221162 0.0014637371 6.113373e-17 2.698416e-15 10 131901074 131901155 82 + 1.821 1.331 -1.676
ENSG00000175470 E009 43.8443663 0.0005815709 1.937907e-09 2.721502e-08 10 131901238 131901265 28 + 1.782 1.464 -1.082
ENSG00000175470 E010 52.5635917 0.0007102821 1.230801e-12 2.977030e-11 10 131901266 131901290 25 + 1.868 1.515 -1.197
ENSG00000175470 E011 80.3838488 0.0003251997 2.822871e-13 7.528993e-12 10 131901291 131901330 40 + 2.028 1.743 -0.957
ENSG00000175470 E012 6.8182020 0.0204971024 5.999971e-03 1.861006e-02 10 131911562 131912598 1037 + 0.651 1.038 1.510
ENSG00000175470 E013 108.4592912 0.0003144546 2.519922e-13 6.770553e-12 10 131934458 131934555 98 + 2.143 1.900 -0.816
ENSG00000175470 E014 3.5836712 0.0046715323 6.557882e-02 1.360102e-01 10 131934894 131935006 113 + 0.773 0.504 -1.171
ENSG00000175470 E015 2.2130482 0.0099954678 1.605178e-01 2.758217e-01 10 131939776 131940030 255 + 0.389 0.631 1.176
ENSG00000175470 E016 178.9614038 0.0010401221 6.146101e-04 2.586835e-03 10 131940031 131940158 128 + 2.300 2.208 -0.307
ENSG00000175470 E017 83.0287139 0.0030673270 7.679245e-02 1.543614e-01 10 131940159 131940162 4 + 1.878 1.968 0.303
ENSG00000175470 E018 104.4841630 0.0032305832 2.151247e-01 3.445731e-01 10 131940163 131940196 34 + 1.992 2.053 0.206
ENSG00000175470 E019 98.7757972 0.0088581195 7.525112e-01 8.386829e-01 10 131940582 131940606 25 + 1.987 2.010 0.079
ENSG00000175470 E020 175.6365433 0.0002037356 6.791611e-01 7.834489e-01 10 131940607 131940694 88 + 2.248 2.249 0.004
ENSG00000175470 E021 9.9775120 0.0042822208 2.881297e-01 4.286681e-01 10 131940695 131940841 147 + 1.090 0.989 -0.370
ENSG00000175470 E022 4.7620020 0.0038832925 9.934336e-02 1.894858e-01 10 131942549 131942658 110 + 0.851 0.632 -0.891
ENSG00000175470 E023 119.4826557 0.0009568932 2.082374e-01 3.363749e-01 10 131943968 131943997 30 + 2.101 2.070 -0.102
ENSG00000175470 E024 184.1425754 0.0003909176 5.664350e-02 1.208363e-01 10 131943998 131944094 97 + 2.290 2.251 -0.129
ENSG00000175470 E025 173.6997571 0.0004683920 3.905660e-01 5.345322e-01 10 131944095 131944145 51 + 2.250 2.238 -0.040
ENSG00000175470 E026 294.0494237 0.0002470942 8.154439e-01 8.831509e-01 10 131945295 131945459 165 + 2.469 2.477 0.025
ENSG00000175470 E027 1.1446155 0.0158450141 1.859922e-03 6.789182e-03 10 131945460 131945925 466 + 0.000 0.550 12.262
ENSG00000175470 E028 380.1549105 0.0001751582 1.844630e-01 3.068118e-01 10 131947530 131947791 262 + 2.566 2.602 0.120
ENSG00000175470 E029 251.6936074 0.0002019642 7.037898e-05 3.819274e-04 10 131955684 131955807 124 + 2.354 2.454 0.336
ENSG00000175470 E030 383.1314961 0.0049282740 9.713276e-05 5.086240e-04 10 131955808 131956086 279 + 2.504 2.658 0.513
ENSG00000175470 E031 233.9549082 0.0012413151 1.993651e-15 7.242401e-14 10 131956087 131956211 125 + 2.245 2.478 0.780
ENSG00000175470 E032 225.0510842 0.0010839972 2.210589e-20 1.477733e-18 10 131956212 131956653 442 + 2.206 2.475 0.899
ENSG00000175470 E033 26.8040384 0.0267327162 7.374941e-01 8.276409e-01 10 131956654 131957190 537 + 1.452 1.428 -0.083
ENSG00000175470 E034 6.3775225 0.0025292459 5.310476e-01 6.635582e-01 10 131957191 131957227 37 + 0.901 0.835 -0.254
ENSG00000175470 E035 5.2830534 0.0031358211 5.225081e-01 6.563163e-01 10 131957228 131957264 37 + 0.833 0.759 -0.290
ENSG00000175470 E036 9.5364569 0.0068418615 6.145547e-01 7.329645e-01 10 131957265 131957374 110 + 1.036 0.990 -0.168
ENSG00000175470 E037 5.6498421 0.1271369207 5.914423e-01 7.142209e-01 10 131957375 131957411 37 + 0.729 0.877 0.584
ENSG00000175470 E038 8.4887342 0.0647388831 6.004963e-01 7.217179e-01 10 131957412 131957527 116 + 0.917 1.014 0.365
ENSG00000175470 E039 5.3990682 0.0029306332 4.299593e-01 5.725950e-01 10 131957528 131957601 74 + 0.851 0.759 -0.361
ENSG00000175470 E040 2.9309717 0.1049191161 9.700030e-01 9.852249e-01 10 131957602 131957641 40 + 0.592 0.593 0.005
ENSG00000175470 E041 2.7773800 0.0103313231 8.680112e-01 9.191023e-01 10 131957642 131957674 33 + 0.558 0.593 0.161
ENSG00000175470 E042 2.8913315 0.0217358945 9.608092e-01 9.793259e-01 10 131957675 131957711 37 + 0.591 0.593 0.007
ENSG00000175470 E043 3.8781932 0.0044145601 6.154377e-01 7.336989e-01 10 131957712 131957821 110 + 0.729 0.667 -0.255
ENSG00000175470 E044 5.8801123 0.0034161780 5.501066e-01 6.797733e-01 10 131957822 131958039 218 + 0.794 0.879 0.332
ENSG00000175470 E045 4.1019037 0.0097498769 2.078462e-01 3.358997e-01 10 131958040 131958113 74 + 0.773 0.594 -0.753
ENSG00000175470 E046 10.0270464 0.0017244923 6.423307e-02 1.337579e-01 10 131958114 131958336 223 + 1.120 0.938 -0.668
ENSG00000175470 E047 3.1721861 0.1092341800 8.528649e-01 9.088351e-01 10 131958337 131958373 37 + 0.622 0.599 -0.103
ENSG00000175470 E048 7.9214855 0.1065117192 9.806983e-01 9.919081e-01 10 131958374 131958632 259 + 0.931 0.951 0.078
ENSG00000175470 E049 3.9870206 0.0567311600 5.827338e-01 7.070170e-01 10 131958633 131958706 74 + 0.729 0.636 -0.387
ENSG00000175470 E050 5.0564103 0.0043961897 6.230140e-01 7.396869e-01 10 131958707 131958780 74 + 0.814 0.759 -0.217
ENSG00000175470 E051 1.3201676 0.3940872727 6.755556e-01 7.807922e-01 10 131958781 131958928 148 + 0.333 0.393 0.352
ENSG00000175470 E052 1.4112044 0.0101243265 1.596120e-01 2.746013e-01 10 131958929 131958965 37 + 0.482 0.238 -1.476
ENSG00000175470 E053 1.4027854 0.0094950198 1.598385e-01 2.749062e-01 10 131958966 131959002 37 + 0.482 0.238 -1.476
ENSG00000175470 E054 2.8314907 0.0174658960 8.584052e-01 9.126393e-01 10 131959003 131959076 74 + 0.558 0.594 0.165
ENSG00000175470 E055 4.3534350 0.0081491469 3.793363e-01 5.235964e-01 10 131959077 131959113 37 + 0.651 0.786 0.555
ENSG00000175470 E056 7.2128531 0.0022634654 8.249952e-01 8.897465e-01 10 131959114 131959150 37 + 0.901 0.938 0.138
ENSG00000175470 E057 2.4691392 0.0060715466 8.966918e-01 9.379794e-01 10 131959151 131959187 37 + 0.521 0.551 0.139
ENSG00000175470 E058 2.5862098 0.0065527406 2.498822e-01 3.857579e-01 10 131959188 131959224 37 + 0.438 0.632 0.917
ENSG00000175470 E059 6.8098158 0.0025377784 7.348392e-01 8.256955e-01 10 131959225 131959409 185 + 0.868 0.919 0.194
ENSG00000175470 E060 4.5362879 0.0040307172 5.517544e-01 6.811742e-01 10 131959410 131959520 111 + 0.773 0.700 -0.296
ENSG00000175470 E061 8.1490659 0.0743715013 6.032932e-02 1.271692e-01 10 131959521 131960149 629 + 0.751 1.090 1.284
ENSG00000175470 E062 0.9317929 0.0815901069 5.890741e-01 7.121780e-01 10 131966159 131966202 44 + 0.335 0.237 -0.676