ENSG00000175467

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000312397 ENSG00000175467 HEK293_OSMI2_2hA HEK293_TMG_2hB SART1 protein_coding protein_coding 74.52427 140.8396 45.94447 7.293468 0.3667461 -1.615879 43.81210 71.86858 30.09009 1.464600 0.6105191 -1.255794 0.6237542 0.5124333 0.6548333 0.1424 0.0006416488 0.0002023997 FALSE TRUE
ENST00000529580 ENSG00000175467 HEK293_OSMI2_2hA HEK293_TMG_2hB SART1 protein_coding retained_intron 74.52427 140.8396 45.94447 7.293468 0.3667461 -1.615879 29.09331 67.30106 14.46398 6.711419 0.6100109 -2.217382 0.3476708 0.4757333 0.3148333 -0.1609 0.0002023997 0.0002023997 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000175467 E001 14.137749 0.0659360642 7.134601e-01 8.099599e-01 11 65961728 65961728 1 + 1.069 1.109 0.146
ENSG00000175467 E002 14.870896 0.0670827547 6.027505e-01 7.236654e-01 11 65961729 65961733 5 + 1.069 1.134 0.236
ENSG00000175467 E003 18.242204 0.0541331752 6.371428e-01 7.510861e-01 11 65961734 65961739 6 + 1.267 1.185 -0.287
ENSG00000175467 E004 469.119767 0.0070698129 3.817644e-07 3.455854e-06 11 65961740 65962093 354 + 2.756 2.526 -0.765
ENSG00000175467 E005 2.846151 0.0119612445 1.634699e-01 2.796717e-01 11 65964006 65964073 68 + 0.695 0.459 -1.076
ENSG00000175467 E006 244.316938 0.0009348253 3.605790e-12 8.069771e-11 11 65964074 65964131 58 + 2.457 2.252 -0.686
ENSG00000175467 E007 1.023493 0.0191075839 6.673779e-01 7.746367e-01 11 65964132 65964512 381 + 0.328 0.243 -0.590
ENSG00000175467 E008 292.148090 0.0012800182 1.313142e-08 1.583721e-07 11 65964515 65964570 56 + 2.509 2.340 -0.564
ENSG00000175467 E009 2.362689 0.1213265630 4.324978e-02 9.701321e-02 11 65965051 65965091 41 + 0.743 0.332 -1.981
ENSG00000175467 E010 522.567250 0.0021876195 3.374162e-05 1.981355e-04 11 65965092 65965218 127 + 2.729 2.604 -0.418
ENSG00000175467 E011 555.663468 0.0003939703 1.655753e-06 1.310813e-05 11 65965342 65965447 106 + 2.737 2.637 -0.332
ENSG00000175467 E012 522.854390 0.0003892196 5.754883e-06 4.040639e-05 11 65965702 65965779 78 + 2.709 2.612 -0.322
ENSG00000175467 E013 502.593727 0.0001368729 3.123402e-04 1.429964e-03 11 65965887 65965986 100 + 2.674 2.599 -0.249
ENSG00000175467 E014 686.993630 0.0008737088 1.399828e-02 3.822434e-02 11 65966076 65966218 143 + 2.797 2.738 -0.197
ENSG00000175467 E015 1.694173 0.0088011750 2.240802e-02 5.652563e-02 11 65966219 65966349 131 + 0.642 0.243 -2.174
ENSG00000175467 E016 846.830811 0.0026572428 2.690124e-01 4.074723e-01 11 65966350 65966556 207 + 2.873 2.834 -0.130
ENSG00000175467 E017 757.518245 0.0008833274 8.082674e-02 1.608376e-01 11 65967259 65967383 125 + 2.828 2.784 -0.146
ENSG00000175467 E018 779.220089 0.0001045811 7.374318e-03 2.219042e-02 11 65967471 65967586 116 + 2.780 2.814 0.110
ENSG00000175467 E019 396.270187 0.0001307045 2.835550e-03 9.780721e-03 11 65967679 65967680 2 + 2.469 2.526 0.189
ENSG00000175467 E020 752.680481 0.0001121486 4.507118e-07 4.022329e-06 11 65967681 65967821 141 + 2.734 2.806 0.242
ENSG00000175467 E021 934.270105 0.0002121109 3.327251e-03 1.122696e-02 11 65976395 65976568 174 + 2.857 2.893 0.120
ENSG00000175467 E022 828.398929 0.0005914199 1.976278e-01 3.232519e-01 11 65976656 65976748 93 + 2.821 2.837 0.053
ENSG00000175467 E023 507.536967 0.0003204597 7.344479e-02 1.490336e-01 11 65976749 65976766 18 + 2.600 2.628 0.095
ENSG00000175467 E024 746.792043 0.0008653561 7.793818e-03 2.325844e-02 11 65977014 65977101 88 + 2.751 2.799 0.159
ENSG00000175467 E025 753.707624 0.0012152594 9.285496e-04 3.714485e-03 11 65977563 65977653 91 + 2.739 2.807 0.226
ENSG00000175467 E026 380.670040 0.0036918090 1.747112e-01 2.943294e-01 11 65977764 65977764 1 + 2.464 2.507 0.145
ENSG00000175467 E027 1009.325613 0.0010039599 3.484969e-04 1.574119e-03 11 65977765 65977899 135 + 2.869 2.933 0.212
ENSG00000175467 E028 5.205732 0.0032611772 1.835264e-02 4.790504e-02 11 65977900 65978152 253 + 0.950 0.622 -1.310
ENSG00000175467 E029 4.532004 0.0254726086 8.675050e-02 1.702064e-01 11 65978487 65978599 113 + 0.858 0.584 -1.130
ENSG00000175467 E030 770.731717 0.0003950458 3.514482e-07 3.205161e-06 11 65978600 65978689 90 + 2.736 2.819 0.278
ENSG00000175467 E031 531.839410 0.0003279772 1.773565e-11 3.542399e-10 11 65978793 65978914 122 + 2.535 2.667 0.439
ENSG00000175467 E032 2.994559 0.0055669531 2.689965e-02 6.578360e-02 11 65978915 65978957 43 + 0.784 0.429 -1.590
ENSG00000175467 E033 194.903953 0.0043552755 5.494595e-03 1.727287e-02 11 65979012 65980137 1126 + 2.113 2.233 0.398