ENSG00000175455

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000409657 ENSG00000175455 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC14 protein_coding nonsense_mediated_decay 14.02001 5.585748 20.37779 1.301547 0.3728009 1.865303 2.0775495 1.97847214 2.5324171 0.41949534 0.56229616 0.3545404 0.19426667 0.357300000 0.12406667 -0.233233333 0.0002635169 8.14543e-05 FALSE TRUE
ENST00000409697 ENSG00000175455 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC14 protein_coding protein_coding 14.02001 5.585748 20.37779 1.301547 0.3728009 1.865303 1.6366637 1.05994918 2.4227735 0.26017997 1.24349506 1.1850598 0.12691667 0.222833333 0.11796667 -0.104866667 0.7558201977 8.14543e-05 FALSE TRUE
ENST00000419247 ENSG00000175455 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC14 protein_coding protein_coding 14.02001 5.585748 20.37779 1.301547 0.3728009 1.865303 0.8004182 0.28811264 0.9930437 0.10133752 0.12309286 1.7504549 0.05458750 0.050966667 0.04893333 -0.002033333 1.0000000000 8.14543e-05 FALSE TRUE
ENST00000426152 ENSG00000175455 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC14 protein_coding protein_coding 14.02001 5.585748 20.37779 1.301547 0.3728009 1.865303 0.9846363 0.21559491 1.9760128 0.14967550 0.61219665 3.1380685 0.05890417 0.033166667 0.09596667 0.062800000 0.3030267609 8.14543e-05 FALSE FALSE
ENST00000485727 ENSG00000175455 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC14 protein_coding protein_coding 14.02001 5.585748 20.37779 1.301547 0.3728009 1.865303 0.9199110 0.11194183 1.7077635 0.03889006 0.08665024 3.8162664 0.05259583 0.019266667 0.08373333 0.064466667 0.0000814543 8.14543e-05 FALSE TRUE
ENST00000488653 ENSG00000175455 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC14 protein_coding protein_coding 14.02001 5.585748 20.37779 1.301547 0.3728009 1.865303 0.8228055 0.53563630 0.7661992 0.33730947 0.76619916 0.5084873 0.07594167 0.078533333 0.03796667 -0.040566667 0.4746821541 8.14543e-05 FALSE TRUE
ENST00000495381 ENSG00000175455 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC14 protein_coding retained_intron 14.02001 5.585748 20.37779 1.301547 0.3728009 1.865303 1.0896251 0.25068985 0.7160139 0.08522737 0.37552817 1.4776627 0.08156667 0.044233333 0.03480000 -0.009433333 0.8467520618 8.14543e-05 FALSE TRUE
MSTRG.23546.11 ENSG00000175455 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC14 protein_coding   14.02001 5.585748 20.37779 1.301547 0.3728009 1.865303 0.8729476 0.00000000 1.5069817 0.00000000 0.53909271 7.2450599 0.04777917 0.000000000 0.07470000 0.074700000 0.0005427100 8.14543e-05 FALSE TRUE
MSTRG.23546.19 ENSG00000175455 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC14 protein_coding   14.02001 5.585748 20.37779 1.301547 0.3728009 1.865303 0.6516718 0.05206081 1.3233238 0.04031059 0.13766883 4.4252008 0.03440417 0.007566667 0.06480000 0.057233333 0.0001890066 8.14543e-05 FALSE TRUE
MSTRG.23546.24 ENSG00000175455 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC14 protein_coding   14.02001 5.585748 20.37779 1.301547 0.3728009 1.865303 0.6978349 0.00000000 1.5207314 0.00000000 0.76164238 7.2580774 0.03855417 0.000000000 0.07596667 0.075966667 0.3464686690 8.14543e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000175455 E001 1.8779411 0.0076994691 1.299896e-01 2.341555e-01 3 123897305 123897510 206 - 0.319 0.594 1.433
ENSG00000175455 E002 3.2182682 0.0487959031 4.393101e-02 9.825855e-02 3 123897511 123897613 103 - 0.420 0.804 1.722
ENSG00000175455 E003 0.0000000       3 123913422 123913452 31 -      
ENSG00000175455 E004 8.2076682 0.0089643424 2.143433e-03 7.670032e-03 3 123913453 123913716 264 - 0.783 1.160 1.408
ENSG00000175455 E005 6.3674814 0.0028743010 1.310681e-01 2.356390e-01 3 123913717 123913724 8 - 0.756 0.964 0.801
ENSG00000175455 E006 5.9904553 0.0026952530 2.641695e-01 4.021157e-01 3 123913725 123913726 2 - 0.742 0.905 0.636
ENSG00000175455 E007 135.2003710 0.0073744156 6.716748e-15 2.274294e-13 3 123913727 123914318 592 - 1.930 2.333 1.350
ENSG00000175455 E008 45.2672550 0.0059361838 2.451829e-04 1.155203e-03 3 123914319 123914393 75 - 1.526 1.781 0.866
ENSG00000175455 E009 87.3646751 0.0122890231 1.438004e-05 9.210101e-05 3 123914394 123914661 268 - 1.794 2.087 0.985
ENSG00000175455 E010 93.7973149 0.0031341727 2.595437e-06 1.970654e-05 3 123914662 123914879 218 - 1.848 2.076 0.765
ENSG00000175455 E011 84.5004244 0.0035776097 1.849302e-03 6.755976e-03 3 123914880 123914994 115 - 1.826 1.994 0.564
ENSG00000175455 E012 88.0633720 0.0054711030 6.750770e-03 2.057652e-02 3 123914995 123915132 138 - 1.847 2.007 0.538
ENSG00000175455 E013 54.8195067 0.0004696192 3.882243e-03 1.281323e-02 3 123915133 123915198 66 - 1.642 1.804 0.547
ENSG00000175455 E014 27.2505342 0.0088172619 6.771344e-02 1.395594e-01 3 123915199 123915199 1 - 1.353 1.513 0.552
ENSG00000175455 E015 61.5414963 0.0014118520 3.984086e-04 1.768281e-03 3 123915200 123915289 90 - 1.678 1.871 0.651
ENSG00000175455 E016 52.3950517 0.0007451377 8.547083e-02 1.681624e-01 3 123915290 123915372 83 - 1.637 1.744 0.365
ENSG00000175455 E017 39.2684222 0.0005939447 7.992812e-01 8.719820e-01 3 123915373 123915399 27 - 1.542 1.572 0.102
ENSG00000175455 E018 31.6409319 0.0053784749 5.014069e-01 6.375555e-01 3 123915400 123915400 1 - 1.441 1.507 0.227
ENSG00000175455 E019 45.7876290 0.0005072238 1.983588e-01 3.241648e-01 3 123915401 123915471 71 - 1.587 1.675 0.298
ENSG00000175455 E020 28.0315593 0.0044654865 6.268829e-01 7.427582e-01 3 123915472 123915481 10 - 1.396 1.447 0.174
ENSG00000175455 E021 81.7283124 0.0009701503 3.256986e-01 4.691466e-01 3 123915482 123915718 237 - 1.870 1.839 -0.104
ENSG00000175455 E022 0.7342825 0.0174040127 2.033215e-01 3.303571e-01 3 123930772 123931101 330 - 0.280 0.001 -9.520
ENSG00000175455 E023 66.9613253 0.0004097387 1.218920e-01 2.226065e-01 3 123931102 123931234 133 - 1.747 1.835 0.298
ENSG00000175455 E024 78.5115290 0.0010755744 9.148239e-01 9.500656e-01 3 123931308 123931526 219 - 1.838 1.857 0.065
ENSG00000175455 E025 0.5159433 0.2027775177 7.225233e-01 8.166082e-01 3 123933525 123933526 2 - 0.134 0.202 0.715
ENSG00000175455 E026 2.3123132 0.0401730830 1.565851e-01 2.705536e-01 3 123933527 123933672 146 - 0.388 0.656 1.287
ENSG00000175455 E027 61.0799776 0.0004130556 8.251786e-01 8.898763e-01 3 123933673 123933755 83 - 1.737 1.739 0.009
ENSG00000175455 E028 77.2296250 0.0004306346 3.173191e-01 4.601827e-01 3 123944849 123944990 142 - 1.848 1.816 -0.109
ENSG00000175455 E029 25.0528521 0.0007547365 9.315811e-01 9.609064e-01 3 123946803 123946803 1 - 1.360 1.366 0.024
ENSG00000175455 E030 78.6696386 0.0003838548 9.098224e-02 1.766848e-01 3 123946804 123947012 209 - 1.860 1.796 -0.216
ENSG00000175455 E031 45.6957235 0.0006850634 5.172226e-01 6.516515e-01 3 123947013 123947057 45 - 1.616 1.592 -0.083
ENSG00000175455 E032 59.7146442 0.0031396376 1.210939e-01 2.215012e-01 3 123947058 123947195 138 - 1.744 1.672 -0.245
ENSG00000175455 E033 38.4298739 0.0009787976 6.392155e-02 1.332235e-01 3 123947196 123947279 84 - 1.566 1.456 -0.379
ENSG00000175455 E034 31.7023422 0.0083948533 3.793907e-02 8.723518e-02 3 123947280 123947300 21 - 1.494 1.337 -0.545
ENSG00000175455 E035 28.4466094 0.0089446159 5.940995e-03 1.845330e-02 3 123947301 123947319 19 - 1.466 1.229 -0.823
ENSG00000175455 E036 40.7874658 0.0015097865 2.541393e-04 1.192439e-03 3 123948691 123948707 17 - 1.620 1.378 -0.832
ENSG00000175455 E037 69.7144171 0.0240710033 6.346209e-02 1.324655e-01 3 123948708 123948785 78 - 1.824 1.703 -0.409
ENSG00000175455 E038 56.3736794 0.0105937344 6.549152e-02 1.358618e-01 3 123948896 123948945 50 - 1.728 1.619 -0.370
ENSG00000175455 E039 87.1343613 0.0083329026 6.010352e-02 1.267807e-01 3 123948946 123949132 187 - 1.912 1.820 -0.311
ENSG00000175455 E040 8.1816548 0.0045764642 5.635411e-03 1.764504e-02 3 123949133 123949313 181 - 0.994 0.594 -1.598
ENSG00000175455 E041 19.3392466 0.0011864454 5.820796e-03 1.813943e-02 3 123949384 123949464 81 - 1.316 1.062 -0.904
ENSG00000175455 E042 20.6763158 0.0009328728 1.830259e-03 6.696303e-03 3 123949465 123949586 122 - 1.346 1.062 -1.006
ENSG00000175455 E043 102.1286042 0.0003017108 3.765634e-35 9.276829e-33 3 123952595 123955842 3248 - 2.063 1.418 -2.188
ENSG00000175455 E044 49.9388015 0.0022614318 9.893649e-03 2.850203e-02 3 123955843 123955965 123 - 1.687 1.537 -0.508
ENSG00000175455 E045 12.9485186 0.0108685120 9.443641e-03 2.739266e-02 3 123955966 123956045 80 - 1.158 0.837 -1.189
ENSG00000175455 E046 35.1150593 0.0402937508 3.806948e-03 1.260006e-02 3 123956046 123956076 31 - 1.573 1.237 -1.161
ENSG00000175455 E047 37.0615553 0.0613605719 4.606132e-02 1.021454e-01 3 123956077 123956115 39 - 1.577 1.353 -0.771
ENSG00000175455 E048 10.2381337 0.0163345184 5.721739e-02 1.218378e-01 3 123956116 123956354 239 - 1.054 0.799 -0.964
ENSG00000175455 E049 39.3260027 0.0005499225 5.970318e-04 2.522770e-03 3 123956355 123956427 73 - 1.601 1.377 -0.768
ENSG00000175455 E050 21.5553197 0.0008544951 1.495174e-04 7.449015e-04 3 123956428 123956739 312 - 1.370 1.016 -1.260
ENSG00000175455 E051 34.9734297 0.0055846513 1.803396e-04 8.794933e-04 3 123956740 123956795 56 - 1.568 1.269 -1.032
ENSG00000175455 E052 15.1140423 0.0011916826 3.294900e-05 1.940646e-04 3 123956796 123958900 2105 - 1.242 0.755 -1.813
ENSG00000175455 E053 33.8523222 0.0005899564 3.969030e-05 2.289231e-04 3 123961144 123961408 265 - 1.555 1.255 -1.040