ENSG00000175376

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000312234 ENSG00000175376 HEK293_OSMI2_2hA HEK293_TMG_2hB EIF1AD protein_coding protein_coding 55.46722 79.19086 47.37029 3.362908 0.6504843 -0.7412291 3.111410 3.991687 2.390878 0.2852499 0.7614193 -0.7370462 0.05667917 0.05063333 0.05056667 -6.666667e-05 9.430828e-01 1.987404e-08 FALSE  
ENST00000526451 ENSG00000175376 HEK293_OSMI2_2hA HEK293_TMG_2hB EIF1AD protein_coding protein_coding 55.46722 79.19086 47.37029 3.362908 0.6504843 -0.7412291 10.577709 16.397684 8.857614 1.1650429 1.2377401 -0.8877537 0.18753333 0.20866667 0.18636667 -2.230000e-02 8.140611e-01 1.987404e-08 FALSE  
ENST00000527051 ENSG00000175376 HEK293_OSMI2_2hA HEK293_TMG_2hB EIF1AD protein_coding protein_coding 55.46722 79.19086 47.37029 3.362908 0.6504843 -0.7412291 5.435688 4.597203 5.859446 0.3342624 0.2922175 0.3493331 0.10487917 0.05793333 0.12383333 6.590000e-02 1.987404e-08 1.987404e-08    
ENST00000527249 ENSG00000175376 HEK293_OSMI2_2hA HEK293_TMG_2hB EIF1AD protein_coding protein_coding 55.46722 79.19086 47.37029 3.362908 0.6504843 -0.7412291 9.028808 13.094368 7.253474 1.6135225 0.7241393 -0.8513162 0.16097917 0.16460000 0.15280000 -1.180000e-02 8.822008e-01 1.987404e-08 FALSE  
ENST00000529964 ENSG00000175376 HEK293_OSMI2_2hA HEK293_TMG_2hB EIF1AD protein_coding protein_coding 55.46722 79.19086 47.37029 3.362908 0.6504843 -0.7412291 4.320897 7.283826 3.308497 1.2885046 0.5800055 -1.1361459 0.07446667 0.09186667 0.06983333 -2.203333e-02 6.638563e-01 1.987404e-08 FALSE  
ENST00000532707 ENSG00000175376 HEK293_OSMI2_2hA HEK293_TMG_2hB EIF1AD protein_coding protein_coding 55.46722 79.19086 47.37029 3.362908 0.6504843 -0.7412291 1.688971 4.886375 0.000000 2.5212560 0.0000000 -8.9355703 0.02645417 0.06186667 0.00000000 -6.186667e-02 1.861360e-01 1.987404e-08 FALSE  
ENST00000533544 ENSG00000175376 HEK293_OSMI2_2hA HEK293_TMG_2hB EIF1AD protein_coding protein_coding 55.46722 79.19086 47.37029 3.362908 0.6504843 -0.7412291 9.871230 15.146844 8.442374 1.2589141 1.4795815 -0.8425408 0.17663750 0.19066667 0.17886667 -1.180000e-02 8.925996e-01 1.987404e-08 FALSE  
MSTRG.5750.4 ENSG00000175376 HEK293_OSMI2_2hA HEK293_TMG_2hB EIF1AD protein_coding   55.46722 79.19086 47.37029 3.362908 0.6504843 -0.7412291 6.922070 7.408001 7.642630 2.0499769 1.3143441 0.0449252 0.13155000 0.09296667 0.16200000 6.903333e-02 3.498976e-01 1.987404e-08 FALSE  
MSTRG.5750.5 ENSG00000175376 HEK293_OSMI2_2hA HEK293_TMG_2hB EIF1AD protein_coding   55.46722 79.19086 47.37029 3.362908 0.6504843 -0.7412291 3.523871 5.224052 2.692309 0.8356383 0.9397932 -0.9537357 0.06231250 0.06586667 0.05633333 -9.533333e-03 8.184147e-01 1.987404e-08 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000175376 E001 1464.090397 0.0017400813 1.474005e-01 2.581593e-01 11 65996545 65998335 1791 - 3.104 3.135 0.106
ENSG00000175376 E002 11.277091 0.0015401000 1.064888e-04 5.518805e-04 11 65998336 65998351 16 - 1.275 0.900 -1.361
ENSG00000175376 E003 87.798610 0.0032378817 3.092756e-04 1.417235e-03 11 65998352 65998388 37 - 2.015 1.850 -0.555
ENSG00000175376 E004 133.801132 0.0004988361 3.020695e-07 2.793564e-06 11 65998389 65998432 44 - 2.197 2.035 -0.543
ENSG00000175376 E005 270.751470 0.0001534964 2.212797e-02 5.593986e-02 11 65998433 65998566 134 - 2.427 2.380 -0.158
ENSG00000175376 E006 259.059827 0.0004048066 3.366578e-01 4.805336e-01 11 65998567 65998613 47 - 2.353 2.381 0.096
ENSG00000175376 E007 411.810431 0.0001967012 3.466627e-02 8.101025e-02 11 65998614 65998743 130 - 2.541 2.587 0.152
ENSG00000175376 E008 223.831505 0.0001879685 7.509411e-01 8.375087e-01 11 65999350 65999359 10 - 2.302 2.315 0.043
ENSG00000175376 E009 209.398162 0.0002368086 4.060426e-01 5.496974e-01 11 65999360 65999362 3 - 2.262 2.289 0.090
ENSG00000175376 E010 271.421688 0.0001742168 6.918027e-02 1.420104e-01 11 65999363 65999397 35 - 2.360 2.408 0.159
ENSG00000175376 E011 312.462552 0.0007069906 1.560526e-01 2.698624e-01 11 65999567 65999636 70 - 2.428 2.468 0.133
ENSG00000175376 E012 261.411140 0.0001882764 5.115774e-01 6.465689e-01 11 65999637 65999675 39 - 2.366 2.386 0.069
ENSG00000175376 E013 5.355186 0.0055555779 5.674209e-03 1.775124e-02 11 65999898 66000052 155 - 0.987 0.628 -1.423
ENSG00000175376 E014 267.639824 0.0006675479 1.111048e-01 2.071652e-01 11 66000053 66000098 46 - 2.358 2.404 0.155
ENSG00000175376 E015 300.594169 0.0002126536 2.255346e-02 5.683123e-02 11 66000099 66000161 63 - 2.399 2.456 0.189
ENSG00000175376 E016 436.105278 0.0001474675 8.813201e-01 9.279407e-01 11 66000303 66000406 104 - 2.599 2.601 0.007
ENSG00000175376 E017 279.645789 0.0001716767 4.695850e-02 1.037524e-01 11 66000407 66000476 70 - 2.436 2.396 -0.134
ENSG00000175376 E018 155.280124 0.0002267837 9.959171e-02 1.898569e-01 11 66000477 66000481 5 - 2.184 2.139 -0.151
ENSG00000175376 E019 87.963483 0.0003326660 9.540856e-03 2.763783e-02 11 66000482 66000505 24 - 1.977 1.879 -0.327
ENSG00000175376 E020 42.677438 0.0012240108 3.920701e-10 6.262247e-09 11 66000506 66000742 237 - 1.810 1.470 -1.159
ENSG00000175376 E021 313.580717 0.0060246165 6.542322e-01 7.644721e-01 11 66001910 66002039 130 - 2.467 2.453 -0.049
ENSG00000175376 E022 330.992837 0.0002532450 5.358793e-01 6.676799e-01 11 66002040 66002176 137 - 2.486 2.477 -0.028