ENSG00000175305

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000308108 ENSG00000175305 HEK293_OSMI2_2hA HEK293_TMG_2hB CCNE2 protein_coding protein_coding 11.05241 2.520655 18.24693 0.1954354 0.5810688 2.850862 6.2873620 1.9357569 11.5986991 0.31244105 0.6228225 2.576803 0.62978333 0.75793333 0.63483333 -0.1231000 3.582212e-01 7.792171e-07 FALSE TRUE
ENST00000524224 ENSG00000175305 HEK293_OSMI2_2hA HEK293_TMG_2hB CCNE2 protein_coding protein_coding 11.05241 2.520655 18.24693 0.1954354 0.5810688 2.850862 0.4884537 0.1913933 0.5298409 0.09634248 0.3256962 1.422518 0.06519167 0.07813333 0.03013333 -0.0480000 7.581954e-01 7.792171e-07 FALSE TRUE
MSTRG.31846.3 ENSG00000175305 HEK293_OSMI2_2hA HEK293_TMG_2hB CCNE2 protein_coding   11.05241 2.520655 18.24693 0.1954354 0.5810688 2.850862 2.6790149 0.1165248 4.3223123 0.03232251 0.1167792 5.097645 0.16792500 0.04843333 0.23766667 0.1892333 7.792171e-07 7.792171e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000175305 E001 4.9733238 0.0138578218 2.180623e-01 3.480806e-01 8 94879770 94880223 454 - 0.682 0.436 -1.140
ENSG00000175305 E002 177.3622230 0.0027065665 1.220091e-11 2.505068e-10 8 94880224 94881351 1128 - 2.053 2.317 0.882
ENSG00000175305 E003 92.1528513 0.0002992820 8.564461e-01 9.112263e-01 8 94881352 94881575 224 - 1.817 1.840 0.077
ENSG00000175305 E004 52.9265049 0.0004264163 2.355330e-01 3.690006e-01 8 94881576 94881613 38 - 1.572 1.662 0.306
ENSG00000175305 E005 84.4104871 0.0003097007 5.937301e-01 7.160665e-01 8 94881614 94881745 132 - 1.776 1.818 0.140
ENSG00000175305 E006 1.0329452 0.0121160782 2.746639e-01 4.138505e-01 8 94881746 94881769 24 - 0.208 0.435 1.491
ENSG00000175305 E007 93.3923287 0.0003518147 9.845280e-01 9.943903e-01 8 94882132 94882289 158 - 1.825 1.840 0.050
ENSG00000175305 E008 65.9105208 0.0005636563 1.124828e-01 2.091610e-01 8 94882781 94882892 112 - 1.689 1.600 -0.300
ENSG00000175305 E009 3.0474401 0.2024552495 1.293931e-01 2.333317e-01 8 94883719 94883921 203 - 0.433 0.784 1.568
ENSG00000175305 E010 74.9786839 0.0010871643 8.988559e-02 1.749533e-01 8 94885067 94885201 135 - 1.744 1.654 -0.307
ENSG00000175305 E011 0.1515154 0.0430789262 8.052698e-01   8 94885452 94885462 11 - 0.050 0.000 -7.560
ENSG00000175305 E012 61.9725152 0.0084643616 3.113700e-01 4.538175e-01 8 94885463 94885558 96 - 1.660 1.591 -0.235
ENSG00000175305 E013 66.6399099 0.0021045723 2.521049e-02 6.230661e-02 8 94887927 94888073 147 - 1.700 1.561 -0.471
ENSG00000175305 E014 52.3883440 0.0004838858 1.591961e-01 2.740452e-01 8 94890415 94890512 98 - 1.593 1.506 -0.296
ENSG00000175305 E015 38.4668543 0.0005591838 7.743169e-01 8.545150e-01 8 94890513 94890550 38 - 1.453 1.443 -0.032
ENSG00000175305 E016 71.1107962 0.0005143091 2.048527e-01 3.322125e-01 8 94892818 94892969 152 - 1.717 1.654 -0.216
ENSG00000175305 E017 0.5891098 0.0183762056 8.649609e-01 9.169745e-01 8 94893507 94893590 84 - 0.173 0.000 -9.537
ENSG00000175305 E018 0.8878743 0.0131438529 4.729489e-01 6.119632e-01 8 94893655 94893890 236 - 0.240 0.000 -10.116
ENSG00000175305 E019 51.4285203 0.0004727318 1.984217e-03 7.177436e-03 8 94893891 94893944 54 - 1.598 1.370 -0.784
ENSG00000175305 E020 0.3030308 0.3532340342 1.000000e+00   8 94893945 94893972 28 - 0.096 0.000 -8.690
ENSG00000175305 E021 62.2556479 0.0004066086 7.894942e-03 2.351502e-02 8 94894023 94894119 97 - 1.674 1.506 -0.573
ENSG00000175305 E022 36.0215141 0.0008836759 1.452519e-02 3.942207e-02 8 94894208 94894247 40 - 1.451 1.240 -0.732
ENSG00000175305 E023 3.7184346 0.0411619054 3.947048e-02 9.004882e-02 8 94894248 94894650 403 - 0.471 0.850 1.634
ENSG00000175305 E024 17.6390841 0.0010230648 3.957287e-01 5.395244e-01 8 94895177 94895254 78 - 1.142 1.055 -0.314
ENSG00000175305 E025 7.1149942 0.0033197495 6.770537e-01 7.818701e-01 8 94895385 94895618 234 - 0.771 0.848 0.300
ENSG00000175305 E026 0.5922303 0.0180108280 4.868071e-01 6.245303e-01 8 94896110 94896451 342 - 0.136 0.270 1.229
ENSG00000175305 E027 3.6880312 0.0404322254 1.077680e-01 2.022399e-01 8 94896452 94896678 227 - 0.489 0.794 1.323