ENSG00000175274

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000395648 ENSG00000175274 HEK293_OSMI2_2hA HEK293_TMG_2hB TP53I11 protein_coding protein_coding 19.8103 33.29499 14.20033 3.40914 0.4921822 -1.228798 10.3000893 18.4896844 5.2916924 1.0416266 0.18483701 -1.8029758 0.51210833 0.56126667 0.37433333 -0.18693333 3.285535e-03 8.974931e-05 FALSE TRUE
ENST00000525680 ENSG00000175274 HEK293_OSMI2_2hA HEK293_TMG_2hB TP53I11 protein_coding protein_coding 19.8103 33.29499 14.20033 3.40914 0.4921822 -1.228798 0.7007914 0.7311606 1.7821961 0.6181953 0.27003279 1.2738705 0.03886250 0.02670000 0.12460000 0.09790000 1.293145e-01 8.974931e-05 FALSE TRUE
ENST00000531130 ENSG00000175274 HEK293_OSMI2_2hA HEK293_TMG_2hB TP53I11 protein_coding processed_transcript 19.8103 33.29499 14.20033 3.40914 0.4921822 -1.228798 1.7427672 3.5104892 0.3224054 1.7975799 0.32240542 -3.4047601 0.06999583 0.09550000 0.02123333 -0.07426667 5.408753e-01 8.974931e-05 FALSE TRUE
ENST00000531928 ENSG00000175274 HEK293_OSMI2_2hA HEK293_TMG_2hB TP53I11 protein_coding protein_coding 19.8103 33.29499 14.20033 3.40914 0.4921822 -1.228798 1.6295283 3.0519935 0.9340680 0.1540230 0.02673262 -1.6975085 0.08090417 0.09490000 0.06580000 -0.02910000 3.734651e-01 8.974931e-05 FALSE TRUE
ENST00000532253 ENSG00000175274 HEK293_OSMI2_2hA HEK293_TMG_2hB TP53I11 protein_coding nonsense_mediated_decay 19.8103 33.29499 14.20033 3.40914 0.4921822 -1.228798 1.0534012 0.5837500 2.1997158 0.2569990 0.07605879 1.8959333 0.06577500 0.01620000 0.15533333 0.13913333 8.974931e-05 8.974931e-05 FALSE TRUE
ENST00000616990 ENSG00000175274 HEK293_OSMI2_2hA HEK293_TMG_2hB TP53I11 protein_coding protein_coding 19.8103 33.29499 14.20033 3.40914 0.4921822 -1.228798 1.7797936 2.8487513 1.6491740 0.8258843 0.20730868 -0.7849199 0.09045833 0.08376667 0.11710000 0.03333333 5.495216e-01 8.974931e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000175274 E001 0.0000000       11 44885903 44886564 662 -      
ENSG00000175274 E002 0.0000000       11 44901220 44901318 99 -      
ENSG00000175274 E003 0.1472490 0.0429642826 2.066357e-01   11 44903356 44903659 304 - 0.171 0.000 -9.719
ENSG00000175274 E004 0.1472490 0.0429642826 2.066357e-01   11 44903780 44903890 111 - 0.171 0.000 -11.822
ENSG00000175274 E005 4.0135934 0.0056568680 3.275663e-01 4.710310e-01 11 44932348 44932355 8 - 0.534 0.712 0.781
ENSG00000175274 E006 743.2875975 0.0068806635 2.917395e-05 1.740871e-04 11 44932356 44933482 1127 - 2.680 2.864 0.612
ENSG00000175274 E007 329.6048665 0.0025319630 8.495036e-03 2.502502e-02 11 44933483 44933865 383 - 2.382 2.494 0.376
ENSG00000175274 E008 658.5613389 0.0001198989 1.231139e-02 3.428070e-02 11 44933866 44934947 1082 - 2.771 2.763 -0.028
ENSG00000175274 E009 86.2350507 0.0050814879 2.200795e-02 5.569514e-02 11 44934948 44934979 32 - 1.949 1.860 -0.301
ENSG00000175274 E010 95.9535464 0.0003577498 1.207546e-03 4.666093e-03 11 44934980 44935017 38 - 2.001 1.903 -0.330
ENSG00000175274 E011 71.3664409 0.0003931916 1.581630e-03 5.899142e-03 11 44935561 44935567 7 - 1.883 1.770 -0.383
ENSG00000175274 E012 85.8957644 0.0011616071 1.884619e-03 6.866726e-03 11 44935568 44935577 10 - 1.956 1.850 -0.357
ENSG00000175274 E013 96.3982951 0.0003258522 7.199063e-03 2.174214e-02 11 44935578 44935619 42 - 1.988 1.911 -0.259
ENSG00000175274 E014 101.2909655 0.0002960606 1.501612e-02 4.052362e-02 11 44935620 44935662 43 - 2.003 1.938 -0.218
ENSG00000175274 E015 10.0988013 0.0017283879 8.648093e-01 9.168650e-01 11 44935663 44936056 394 - 0.965 1.009 0.162
ENSG00000175274 E016 17.2026274 0.0013558894 1.174143e-01 2.162615e-01 11 44936218 44936373 156 - 1.084 1.257 0.618
ENSG00000175274 E017 24.1027708 0.0007908721 8.634793e-04 3.485890e-03 11 44936374 44936455 82 - 1.101 1.414 1.105
ENSG00000175274 E018 29.1580115 0.0007649186 3.256378e-05 1.920465e-04 11 44936456 44936558 103 - 1.133 1.498 1.276
ENSG00000175274 E019 37.8766537 0.0005785547 1.905617e-06 1.489438e-05 11 44936559 44936667 109 - 1.242 1.611 1.278
ENSG00000175274 E020 24.2994368 0.0008230415 1.781903e-04 8.701988e-04 11 44936668 44936689 22 - 1.066 1.422 1.256
ENSG00000175274 E021 5.4789584 0.0031975816 5.486866e-01 6.785187e-01 11 44936690 44936802 113 - 0.687 0.796 0.442
ENSG00000175274 E022 88.0907322 0.0003230154 2.978544e-01 4.392314e-01 11 44936803 44936803 1 - 1.907 1.892 -0.053
ENSG00000175274 E023 116.9991378 0.0002689202 1.429053e-01 2.519870e-01 11 44936804 44936842 39 - 2.035 2.010 -0.085
ENSG00000175274 E024 91.2418155 0.0003526166 5.660024e-02 1.207598e-01 11 44936843 44936849 7 - 1.947 1.898 -0.166
ENSG00000175274 E025 87.1053410 0.0003350404 2.074484e-02 5.304926e-02 11 44936850 44936856 7 - 1.940 1.873 -0.226
ENSG00000175274 E026 91.9958651 0.0014810805 1.752508e-01 2.950075e-01 11 44936857 44936879 23 - 1.937 1.907 -0.103
ENSG00000175274 E027 72.9549727 0.0042692840 2.160055e-01 3.455866e-01 11 44936880 44936882 3 - 1.843 1.806 -0.125
ENSG00000175274 E028 86.0093686 0.0003658865 1.836506e-01 3.057889e-01 11 44936883 44936899 17 - 1.907 1.879 -0.095
ENSG00000175274 E029 3.1417180 0.0063426530 8.691073e-01 9.198773e-01 11 44936900 44937108 209 - 0.591 0.585 -0.029
ENSG00000175274 E030 3.1686848 0.0059806804 3.945697e-01 5.383937e-01 11 44937109 44937303 195 - 0.468 0.632 0.762
ENSG00000175274 E031 85.1340766 0.0003411079 5.582803e-01 6.865463e-01 11 44937304 44937320 17 - 1.881 1.883 0.008
ENSG00000175274 E032 86.4802536 0.0012501028 9.327528e-01 9.616249e-01 11 44937321 44937352 32 - 1.867 1.898 0.106
ENSG00000175274 E033 109.1540399 0.0012096989 6.784036e-01 7.828846e-01 11 44937555 44937613 59 - 1.979 1.991 0.038
ENSG00000175274 E034 152.9671007 0.0064326124 6.206073e-02 1.300952e-01 11 44938207 44938366 160 - 2.175 2.118 -0.191
ENSG00000175274 E035 0.7019140 0.0164168884 4.046128e-01 5.483182e-01 11 44938367 44938417 51 - 0.294 0.158 -1.141
ENSG00000175274 E036 3.2753523 0.0049370600 6.333335e-02 1.322507e-01 11 44939114 44939165 52 - 0.766 0.504 -1.143
ENSG00000175274 E037 14.6752014 0.0012815037 9.309643e-01 9.605507e-01 11 44939166 44939190 25 - 1.117 1.151 0.121
ENSG00000175274 E038 13.5021498 0.0013641041 4.869177e-03 1.556538e-02 11 44939191 44939281 91 - 0.833 1.177 1.273
ENSG00000175274 E039 0.6653823 0.0172671820 6.591361e-02 1.365595e-01 11 44940514 44940747 234 - 0.389 0.086 -2.726
ENSG00000175274 E040 4.1037859 0.0135507144 9.475680e-01 9.710222e-01 11 44941003 44941077 75 - 0.642 0.674 0.137
ENSG00000175274 E041 0.0000000       11 44943152 44943191 40 -      
ENSG00000175274 E042 0.7718584 0.0161231528 1.683276e-01 2.860198e-01 11 44947039 44947253 215 - 0.389 0.158 -1.729
ENSG00000175274 E043 0.5169874 0.0205923712 8.943155e-01 9.364554e-01 11 44949973 44950208 236 - 0.171 0.158 -0.143
ENSG00000175274 E044 57.3379363 0.0127322238 3.586960e-03 1.197383e-02 11 44950677 44950876 200 - 1.831 1.657 -0.590
ENSG00000175274 E045 16.0431320 0.0017902798 1.088520e-02 3.089345e-02 11 44950877 44951306 430 - 1.308 1.109 -0.708