ENSG00000175215

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000398073 ENSG00000175215 HEK293_OSMI2_2hA HEK293_TMG_2hB CTDSP2 protein_coding protein_coding 28.20894 31.4525 22.64535 2.328417 0.2262628 -0.4737816 20.118572 25.086732 15.0779801 1.4903797 0.1642983 -0.7340998 0.70697500 0.79973333 0.66586667 -0.133866667 0.001282438 0.001282438 FALSE TRUE
ENST00000547169 ENSG00000175215 HEK293_OSMI2_2hA HEK293_TMG_2hB CTDSP2 protein_coding retained_intron 28.20894 31.4525 22.64535 2.328417 0.2262628 -0.4737816 2.014568 1.423839 1.9942145 0.2730937 0.7052624 0.4831542 0.07292083 0.04456667 0.08870000 0.044133333 0.461481731 0.001282438 FALSE TRUE
ENST00000549039 ENSG00000175215 HEK293_OSMI2_2hA HEK293_TMG_2hB CTDSP2 protein_coding protein_coding 28.20894 31.4525 22.64535 2.328417 0.2262628 -0.4737816 1.983544 1.623851 0.9847778 0.2944411 0.9847778 -0.7158300 0.07029583 0.05276667 0.04280000 -0.009966667 0.280291037 0.001282438 FALSE TRUE
MSTRG.7538.3 ENSG00000175215 HEK293_OSMI2_2hA HEK293_TMG_2hB CTDSP2 protein_coding   28.20894 31.4525 22.64535 2.328417 0.2262628 -0.4737816 1.677440 1.564397 2.0861057 0.3476059 0.3736467 0.4129117 0.06246667 0.04916667 0.09233333 0.043166667 0.210133193 0.001282438 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000175215 E001 1675.5090477 0.0008241817 3.187877e-10 5.168010e-09 12 57819927 57822799 2873 - 3.135 3.228 0.309
ENSG00000175215 E002 138.5188076 0.0002807480 3.978158e-01 5.415723e-01 12 57822800 57822890 91 - 2.126 2.114 -0.038
ENSG00000175215 E003 345.7287574 0.0003053596 4.287300e-01 5.714560e-01 12 57822891 57823182 292 - 2.491 2.523 0.106
ENSG00000175215 E004 429.4635949 0.0018744371 7.326055e-01 8.240409e-01 12 57823183 57823460 278 - 2.602 2.610 0.024
ENSG00000175215 E005 323.7617708 0.0002704006 8.740233e-02 1.711983e-01 12 57823461 57823652 192 - 2.498 2.477 -0.069
ENSG00000175215 E006 202.7489846 0.0002289587 8.687662e-01 9.196448e-01 12 57823653 57823727 75 - 2.276 2.286 0.036
ENSG00000175215 E007 165.1074449 0.0002286805 4.687285e-01 6.081169e-01 12 57823904 57823957 54 - 2.197 2.191 -0.019
ENSG00000175215 E008 144.2333752 0.0005008080 2.286766e-01 3.608701e-01 12 57823958 57824005 48 - 2.152 2.129 -0.076
ENSG00000175215 E009 193.2749057 0.0002050723 1.780899e-01 2.987436e-01 12 57824006 57824089 84 - 2.276 2.255 -0.068
ENSG00000175215 E010 194.1856808 0.0004259923 1.545278e-01 2.677903e-01 12 57824227 57824319 93 - 2.277 2.254 -0.080
ENSG00000175215 E011 3.5687044 0.0309029663 2.649352e-01 4.029466e-01 12 57824320 57824543 224 - 0.747 0.579 -0.715
ENSG00000175215 E012 133.9204292 0.0002879204 4.837381e-02 1.062870e-01 12 57826346 57826378 33 - 2.132 2.085 -0.160
ENSG00000175215 E013 125.2571669 0.0010081792 4.472721e-01 5.886702e-01 12 57826379 57826402 24 - 2.085 2.073 -0.038
ENSG00000175215 E014 159.8962001 0.0044703089 2.329639e-01 3.659532e-01 12 57826996 57827090 95 - 2.205 2.169 -0.118
ENSG00000175215 E015 90.7960152 0.0031318998 5.794023e-02 1.231058e-01 12 57827091 57827097 7 - 1.982 1.911 -0.240
ENSG00000175215 E016 3.6690361 0.0056793139 7.239440e-01 8.176362e-01 12 57827098 57827123 26 - 0.593 0.659 0.288
ENSG00000175215 E017 3.0164173 0.0058487547 1.185923e-01 2.179312e-01 12 57827124 57827407 284 - 0.713 0.482 -1.035
ENSG00000175215 E018 10.6680474 0.0018752699 1.420177e-02 3.868138e-02 12 57827534 57827551 18 - 1.181 0.948 -0.847
ENSG00000175215 E019 120.7750040 0.0002910278 1.986382e-02 5.120198e-02 12 57827552 57827590 39 - 2.101 2.038 -0.209
ENSG00000175215 E020 130.0819885 0.0002944472 1.571654e-03 5.866668e-03 12 57829448 57829543 96 - 2.147 2.061 -0.288
ENSG00000175215 E021 88.8081323 0.0019123683 3.340988e-05 1.963945e-04 12 57829544 57829596 53 - 2.027 1.866 -0.542
ENSG00000175215 E022 0.3729606 0.0315645267 7.011283e-01 8.004093e-01 12 57845440 57845534 95 - 0.151 0.099 -0.711
ENSG00000175215 E023 93.9413058 0.0022011811 6.383888e-03 1.962074e-02 12 57846372 57846729 358 - 2.017 1.917 -0.337