ENSG00000175198

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000376279 ENSG00000175198 HEK293_OSMI2_2hA HEK293_TMG_2hB PCCA protein_coding protein_coding 7.42189 4.342805 8.553327 0.2111394 0.2017884 0.9762262 0.4523776 0.1486334 0.6479510 0.1486334 0.34660510 2.0522838 0.05399167 0.03146667 0.07390000 0.04243333 0.70031256 0.01894697 FALSE TRUE
ENST00000376285 ENSG00000175198 HEK293_OSMI2_2hA HEK293_TMG_2hB PCCA protein_coding protein_coding 7.42189 4.342805 8.553327 0.2111394 0.2017884 0.9762262 5.1062151 2.8887925 6.2803791 0.0940568 0.35286616 1.1176949 0.67378750 0.66720000 0.73516667 0.06796667 0.60311253 0.01894697 FALSE TRUE
ENST00000458283 ENSG00000175198 HEK293_OSMI2_2hA HEK293_TMG_2hB PCCA protein_coding protein_coding 7.42189 4.342805 8.553327 0.2111394 0.2017884 0.9762262 0.6098590 0.5552184 0.4818312 0.2931241 0.48183122 -0.2006451 0.08402917 0.13286667 0.05890000 -0.07396667 0.53124101 0.01894697 FALSE TRUE
ENST00000637358 ENSG00000175198 HEK293_OSMI2_2hA HEK293_TMG_2hB PCCA protein_coding protein_coding 7.42189 4.342805 8.553327 0.2111394 0.2017884 0.9762262 0.2416331 0.3568254 0.1980795 0.1069488 0.03013499 -0.8179583 0.04292500 0.08023333 0.02333333 -0.05690000 0.01894697 0.01894697 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000175198 E001 0.4386386 0.1040033419 1.0000000000 1.000000000 13 100089015 100089092 78 + 0.172 0.156 -0.161
ENSG00000175198 E002 0.7331366 0.0189319466 0.4448184333 0.586367066 13 100089093 100089099 7 + 0.295 0.157 -1.155
ENSG00000175198 E003 12.3584195 0.0014048112 0.1103583896 0.206065784 13 100089100 100089225 126 + 1.178 1.025 -0.553
ENSG00000175198 E004 10.0416087 0.0017146718 0.5337733612 0.665906508 13 100102883 100102898 16 + 1.067 1.007 -0.222
ENSG00000175198 E005 17.7832980 0.0010365404 0.2112502332 0.339976918 13 100102899 100102960 62 + 1.310 1.211 -0.348
ENSG00000175198 E006 0.1472490 0.0449525042 0.8683028076   13 100104464 100104560 97 + 0.094 0.000 -10.320
ENSG00000175198 E007 21.4122124 0.0009518090 0.0192017378 0.049773710 13 100111841 100111888 48 + 1.411 1.234 -0.618
ENSG00000175198 E008 24.5479962 0.0011647416 0.0066387782 0.020285756 13 100111993 100112061 69 + 1.472 1.276 -0.680
ENSG00000175198 E009 0.1472490 0.0449525042 0.8683028076   13 100149201 100149705 505 + 0.094 0.000 -10.320
ENSG00000175198 E010 0.5900403 0.4982197011 0.8407652229 0.900617161 13 100154494 100154656 163 + 0.237 0.154 -0.773
ENSG00000175198 E011 36.5417031 0.0106193806 0.1164426195 0.214881209 13 100154979 100155092 114 + 1.613 1.492 -0.415
ENSG00000175198 E012 28.5939090 0.0009204936 0.0273470328 0.066701097 13 100157287 100157340 54 + 1.519 1.374 -0.499
ENSG00000175198 E013 1.3371049 0.4849036056 0.2306430598 0.363227475 13 100160673 100161625 953 + 0.173 0.522 2.254
ENSG00000175198 E014 46.7924103 0.0005283735 0.0256714975 0.063260294 13 100209332 100209463 132 + 1.714 1.600 -0.386
ENSG00000175198 E015 29.6500513 0.0171898189 0.4005091526 0.544209043 13 100235842 100235878 37 + 1.503 1.425 -0.267
ENSG00000175198 E016 9.4153631 0.0653298752 0.0022672038 0.008051644 13 100236481 100237497 1017 + 0.749 1.245 1.846
ENSG00000175198 E017 30.6803696 0.0163207493 0.2166670330 0.346375814 13 100257595 100257673 79 + 1.529 1.417 -0.382
ENSG00000175198 E018 29.1141332 0.0007126183 0.9303543971 0.960181571 13 100262729 100262831 103 + 1.465 1.474 0.032
ENSG00000175198 E019 34.1698701 0.0006452011 0.4165525704 0.559912551 13 100268689 100268783 95 + 1.556 1.511 -0.154
ENSG00000175198 E020 42.5894440 0.0005320150 0.0072348583 0.021833886 13 100273196 100273346 151 + 1.684 1.539 -0.495
ENSG00000175198 E021 0.1482932 0.0405600397 0.2772612101   13 100293224 100293254 31 + 0.000 0.157 11.734
ENSG00000175198 E022 44.1945167 0.0005209546 0.2071171444 0.335070166 13 100301460 100301603 144 + 1.673 1.610 -0.216
ENSG00000175198 E023 34.1636263 0.0008264218 0.6028717299 0.723755525 13 100302924 100302996 73 + 1.525 1.560 0.119
ENSG00000175198 E024 21.9180045 0.0014715962 0.4510708366 0.592073836 13 100302997 100302998 2 + 1.330 1.390 0.207
ENSG00000175198 E025 0.8836199 0.1024086711 0.8878408706 0.932303806 13 100305776 100305834 59 + 0.294 0.270 -0.169
ENSG00000175198 E026 35.7439539 0.0007053409 0.7558763768 0.841091252 13 100307192 100307260 69 + 1.564 1.550 -0.050
ENSG00000175198 E027 35.7744842 0.0006596447 0.4899509277 0.627317190 13 100309833 100309908 76 + 1.576 1.539 -0.126
ENSG00000175198 E028 43.6919082 0.0031395867 0.5992779504 0.720715373 13 100330561 100330671 111 + 1.633 1.669 0.120
ENSG00000175198 E029 0.0000000       13 100330672 100330672 1 +      
ENSG00000175198 E030 44.5688695 0.0061861236 0.5314897449 0.663922395 13 100340157 100340259 103 + 1.638 1.686 0.162
ENSG00000175198 E031 27.0142855 0.0009342933 0.9136227423 0.949289952 13 100368472 100368498 27 + 1.450 1.447 -0.009
ENSG00000175198 E032 36.4784355 0.0005896069 0.0897510351 0.174747067 13 100368499 100368574 76 + 1.522 1.623 0.345
ENSG00000175198 E033 40.6069901 0.0005423580 0.0377231185 0.086811929 13 100425633 100425731 99 + 1.562 1.678 0.397
ENSG00000175198 E034 36.4231911 0.0069190012 0.2902576114 0.431041802 13 100449252 100449305 54 + 1.532 1.602 0.240
ENSG00000175198 E035 0.0000000       13 100489968 100491649 1682 +      
ENSG00000175198 E036 0.9254501 0.0133499541 0.8928867511 0.935554024 13 100491650 100491817 168 + 0.295 0.272 -0.155
ENSG00000175198 E037 43.8069447 0.0005108539 0.0002242895 0.001067478 13 100515427 100515567 141 + 1.556 1.751 0.664
ENSG00000175198 E038 1.4381962 0.0305219263 0.0744233123 0.150612343 13 100527297 100527344 48 + 0.238 0.557 1.840
ENSG00000175198 E039 41.5079779 0.0143891541 0.0362273136 0.084017725 13 100527675 100527752 78 + 1.550 1.713 0.551
ENSG00000175198 E040 48.4004874 0.0010387845 0.0040338586 0.013237068 13 100530098 100530437 340 + 1.624 1.774 0.509