ENSG00000175161

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000407528 ENSG00000175161 HEK293_OSMI2_2hA HEK293_TMG_2hB CADM2 protein_coding protein_coding 1.471829 2.057428 1.233521 0.1573063 0.2381784 -0.7334062 0.1086131 0.03708151 0.1804024 0.01883588 0.01751903 2.0158192 0.08995833 0.01956667 0.1629333 0.14336667 0.006178535 0.006178535 FALSE TRUE
ENST00000485126 ENSG00000175161 HEK293_OSMI2_2hA HEK293_TMG_2hB CADM2 protein_coding processed_transcript 1.471829 2.057428 1.233521 0.1573063 0.2381784 -0.7334062 0.7777454 1.14639224 0.6099779 0.14975057 0.11673664 -0.8993422 0.51112917 0.56733333 0.5094333 -0.05790000 0.847049486 0.006178535 TRUE FALSE
MSTRG.23292.1 ENSG00000175161 HEK293_OSMI2_2hA HEK293_TMG_2hB CADM2 protein_coding   1.471829 2.057428 1.233521 0.1573063 0.2381784 -0.7334062 0.5544141 0.86019670 0.4431409 0.26177193 0.17605256 -0.9413820 0.37400417 0.40726667 0.3276333 -0.07963333 0.850069290 0.006178535 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000175161 E001 0.9222279 0.013561505 9.876279e-01 9.963371e-01 3 84958989 84959004 16 + 0.306 0.285 -0.143
ENSG00000175161 E002 19.9413851 0.005746056 2.345414e-04 1.110746e-03 3 84959005 84959492 488 + 1.156 1.402 0.862
ENSG00000175161 E003 6.4965520 0.002702600 2.666733e-01 4.049054e-01 3 84959493 84959545 53 + 0.811 0.910 0.383
ENSG00000175161 E004 7.6423014 0.002485279 2.407357e-01 3.750363e-01 3 84959546 84959589 44 + 0.875 0.972 0.366
ENSG00000175161 E005 12.2062949 0.001898498 1.667304e-02 4.421861e-02 3 84959590 84959668 79 + 1.010 1.192 0.658
ENSG00000175161 E006 7.9175016 0.002878344 9.460884e-06 6.324404e-05 3 84960097 84960438 342 + 0.610 1.106 1.936
ENSG00000175161 E007 7.1584598 0.071660393 4.971815e-01 6.337285e-01 3 85041579 85041778 200 + 0.854 0.934 0.304
ENSG00000175161 E008 0.0000000       3 85726482 85726521 40 +      
ENSG00000175161 E009 0.0000000       3 85726522 85726548 27 +      
ENSG00000175161 E010 2.1379097 0.008434103 2.758791e-01 4.152786e-01 3 85802047 85802196 150 + 0.610 0.406 -0.990
ENSG00000175161 E011 2.0605904 0.007925469 7.685550e-01 8.504142e-01 3 85883291 85883443 153 + 0.530 0.456 -0.364
ENSG00000175161 E012 1.6650287 0.008857862 5.191342e-01 6.532652e-01 3 85886190 85886327 138 + 0.484 0.350 -0.724
ENSG00000175161 E013 2.7679168 0.005842550 4.551905e-01 5.957230e-01 3 85912373 85912543 171 + 0.645 0.501 -0.654
ENSG00000175161 E014 2.8315038 0.005746056 7.958378e-01 8.696327e-01 3 85935767 85935857 91 + 0.610 0.542 -0.309
ENSG00000175161 E015 4.7619014 0.003864897 2.371871e-02 5.923175e-02 3 85961469 85961647 179 + 0.912 0.579 -1.362
ENSG00000175161 E016 3.4384985 0.005506375 2.839434e-02 6.880648e-02 3 85979164 85979283 120 + 0.811 0.456 -1.556
ENSG00000175161 E017 1.4039313 0.013404836 1.337867e-02 3.679820e-02 3 86065605 86065730 126 + 0.572 0.117 -3.139
ENSG00000175161 E018 15.2826297 0.046832424 3.772599e-07 3.418345e-06 3 86066665 86074429 7765 + 1.468 0.797 -2.430