ENSG00000175115

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000320580 ENSG00000175115 HEK293_OSMI2_2hA HEK293_TMG_2hB PACS1 protein_coding protein_coding 11.00672 18.97809 7.243576 0.6025348 0.07186936 -1.38833 7.8039263 11.0203393 6.56113571 1.7221419 0.09237311 -0.7472625 0.74424583 0.5762667 0.905933333 0.3296667 6.204359e-05 1.073278e-10 FALSE TRUE
ENST00000524815 ENSG00000175115 HEK293_OSMI2_2hA HEK293_TMG_2hB PACS1 protein_coding protein_coding 11.00672 18.97809 7.243576 0.6025348 0.07186936 -1.38833 0.1227569 0.9820554 0.00000000 0.5044099 0.00000000 -6.6323488 0.00658750 0.0527000 0.000000000 -0.0527000 2.672991e-01 1.073278e-10 FALSE TRUE
ENST00000529677 ENSG00000175115 HEK293_OSMI2_2hA HEK293_TMG_2hB PACS1 protein_coding protein_coding 11.00672 18.97809 7.243576 0.6025348 0.07186936 -1.38833 1.2126209 3.8591526 0.06064279 0.4550973 0.03310172 -5.7753314 0.07695833 0.2052000 0.008366667 -0.1968333 1.073278e-10 1.073278e-10 FALSE TRUE
ENST00000529757 ENSG00000175115 HEK293_OSMI2_2hA HEK293_TMG_2hB PACS1 protein_coding protein_coding 11.00672 18.97809 7.243576 0.6025348 0.07186936 -1.38833 0.9657539 2.4282374 0.00000000 0.6153555 0.00000000 -7.9296948 0.06505833 0.1303000 0.000000000 -0.1303000 6.755156e-09 1.073278e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000175115 E001 2.2195720 0.0290448665 3.794350e-08 4.188488e-07 11 66070272 66070362 91 + 0.903 0.000 -15.936
ENSG00000175115 E002 47.6756956 0.0008399066 2.657859e-09 3.644232e-08 11 66070363 66070842 480 + 1.815 1.537 -0.943
ENSG00000175115 E003 0.1817044 0.0394756277 1.000000e+00   11 66083973 66084230 258 + 0.000 0.089 12.486
ENSG00000175115 E004 0.1817044 0.0394756277 1.000000e+00   11 66100763 66100874 112 + 0.000 0.089 12.486
ENSG00000175115 E005 0.1472490 0.0431402267 2.198646e-01   11 66121021 66121067 47 + 0.166 0.000 -14.812
ENSG00000175115 E006 48.1520217 0.0006606992 8.910232e-07 7.479028e-06 11 66193486 66193573 88 + 1.790 1.567 -0.754
ENSG00000175115 E007 61.2963677 0.0004648019 1.063606e-09 1.569291e-08 11 66210362 66210451 90 + 1.907 1.661 -0.831
ENSG00000175115 E008 87.4756296 0.0019342254 8.179382e-06 5.543247e-05 11 66211134 66211259 126 + 2.005 1.847 -0.531
ENSG00000175115 E009 72.4829954 0.0003865199 2.383206e-02 5.946700e-02 11 66216119 66216197 79 + 1.865 1.800 -0.219
ENSG00000175115 E010 72.7106490 0.0038608261 4.313349e-01 5.738903e-01 11 66216198 66216263 66 + 1.824 1.819 -0.018
ENSG00000175115 E011 54.9439000 0.0019162709 2.371291e-01 3.708667e-01 11 66216520 66216542 23 + 1.718 1.689 -0.098
ENSG00000175115 E012 77.7012443 0.0013736294 3.023648e-01 4.442333e-01 11 66216543 66216611 69 + 1.854 1.842 -0.040
ENSG00000175115 E013 95.2964001 0.0049519899 9.236865e-02 1.788108e-01 11 66216695 66216775 81 + 1.968 1.921 -0.157
ENSG00000175115 E014 0.5514428 0.0196420121 2.916709e-01 4.325574e-01 11 66216776 66217505 730 + 0.000 0.226 14.114
ENSG00000175115 E015 1.5563746 0.0134324435 4.089716e-01 5.525807e-01 11 66217506 66217617 112 + 0.457 0.330 -0.713
ENSG00000175115 E016 1.1049644 0.0859686392 1.940252e-01 3.188401e-01 11 66217618 66218697 1080 + 0.457 0.225 -1.456
ENSG00000175115 E017 0.6955713 0.0163045506 4.354320e-01 5.776701e-01 11 66219545 66219745 201 + 0.286 0.163 -1.034
ENSG00000175115 E018 75.8889510 0.0050154124 1.017080e-01 1.930983e-01 11 66219746 66219805 60 + 1.870 1.820 -0.168
ENSG00000175115 E019 1.6941604 0.0330223263 7.337083e-02 1.489151e-01 11 66220288 66220630 343 + 0.579 0.282 -1.614
ENSG00000175115 E020 67.6081516 0.0008831238 3.243430e-02 7.669317e-02 11 66220631 66220669 39 + 1.830 1.765 -0.221
ENSG00000175115 E021 98.6833108 0.0009256900 1.415027e-02 3.856661e-02 11 66220670 66220791 122 + 1.991 1.929 -0.209
ENSG00000175115 E022 79.2548153 0.0011279873 2.000588e-01 3.263321e-01 11 66221154 66221247 94 + 1.870 1.848 -0.074
ENSG00000175115 E023 1.4435834 0.0095630297 3.048613e-02 7.292029e-02 11 66221248 66221643 396 + 0.579 0.226 -2.036
ENSG00000175115 E024 76.8598483 0.0003431833 2.239964e-01 3.551847e-01 11 66227504 66227584 81 + 1.776 1.865 0.300
ENSG00000175115 E025 0.9244034 0.0132399363 5.839968e-01 7.079962e-01 11 66230380 66230547 168 + 0.166 0.281 0.965
ENSG00000175115 E026 97.4395287 0.0005605457 1.528008e-01 2.654702e-01 11 66230548 66230663 116 + 1.873 1.966 0.314
ENSG00000175115 E027 98.7620762 0.0003310817 1.305030e-01 2.348616e-01 11 66230805 66230940 136 + 1.878 1.973 0.319
ENSG00000175115 E028 0.6632174 0.0200301107 8.007903e-01 8.730283e-01 11 66231794 66232171 378 + 0.166 0.226 0.547
ENSG00000175115 E029 77.1233157 0.0008270071 9.131535e-01 9.489637e-01 11 66232172 66232276 105 + 1.827 1.857 0.100
ENSG00000175115 E030 77.6735245 0.0003530606 7.288089e-01 8.211891e-01 11 66232960 66233066 107 + 1.836 1.855 0.065
ENSG00000175115 E031 56.8182938 0.0004550323 6.973634e-01 7.974924e-01 11 66233785 66233819 35 + 1.706 1.721 0.049
ENSG00000175115 E032 73.5103811 0.0004643577 4.603431e-01 6.003884e-01 11 66233820 66233909 90 + 1.824 1.826 0.005
ENSG00000175115 E033 54.7296173 0.0004444795 2.678992e-01 4.062816e-01 11 66233910 66233939 30 + 1.714 1.692 -0.076
ENSG00000175115 E034 88.0302667 0.0003598652 5.213917e-01 6.552789e-01 11 66234132 66234242 111 + 1.897 1.905 0.028
ENSG00000175115 E035 86.4759713 0.0003179207 2.212770e-01 3.519605e-01 11 66235301 66235403 103 + 1.904 1.889 -0.053
ENSG00000175115 E036 0.0000000       11 66235404 66235517 114 +      
ENSG00000175115 E037 57.6012090 0.0122669122 8.412518e-01 9.009678e-01 11 66235898 66235940 43 + 1.707 1.727 0.067
ENSG00000175115 E038 0.5546650 0.0200271058 9.354799e-01 9.633956e-01 11 66238516 66238803 288 + 0.166 0.163 -0.034
ENSG00000175115 E039 57.8541116 0.0056291628 1.475132e-01 2.583066e-01 11 66238804 66238846 43 + 1.759 1.706 -0.180
ENSG00000175115 E040 113.8110508 0.0016371706 8.405876e-01 9.005070e-01 11 66239142 66239277 136 + 1.995 2.022 0.090
ENSG00000175115 E041 1.5875059 0.0291921732 2.145699e-02 5.455374e-02 11 66239278 66239739 462 + 0.000 0.483 15.608
ENSG00000175115 E042 0.0000000       11 66240948 66241074 127 +      
ENSG00000175115 E043 0.5848540 0.0260972916 2.932208e-01 4.342689e-01 11 66241227 66241426 200 + 0.000 0.226 14.095
ENSG00000175115 E044 59.6552978 0.0017992664 3.258735e-01 4.693164e-01 11 66241427 66241447 21 + 1.673 1.761 0.296
ENSG00000175115 E045 144.9434509 0.0002885134 7.461126e-01 8.339605e-01 11 66241448 66241653 206 + 2.098 2.123 0.082
ENSG00000175115 E046 109.0837107 0.0002719426 9.205076e-02 1.783139e-01 11 66242912 66243031 120 + 1.922 2.020 0.330
ENSG00000175115 E047 598.0089464 0.0062292229 1.184105e-11 2.435141e-10 11 66243165 66244744 1580 + 2.514 2.798 0.946