ENSG00000175029

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000531469 ENSG00000175029 HEK293_OSMI2_2hA HEK293_TMG_2hB CTBP2 protein_coding protein_coding 36.84569 26.26601 53.78111 2.547787 0.9801153 1.033622 2.121284 0.2416268 4.484201 0.1898464 1.363117 4.1587072 0.05115417 0.0104000 0.08433333 0.07393333 0.083724159 0.002265523 FALSE TRUE
MSTRG.4789.9 ENSG00000175029 HEK293_OSMI2_2hA HEK293_TMG_2hB CTBP2 protein_coding   36.84569 26.26601 53.78111 2.547787 0.9801153 1.033622 23.451783 20.7312785 32.207161 2.6090171 1.819001 0.6353245 0.65029167 0.7853333 0.59806667 -0.18726667 0.002265523 0.002265523 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000175029 E001 149.9012625 0.0003537722 1.412961e-13 3.929554e-12 10 124984317 124988189 3873 - 2.251 2.031 -0.736
ENSG00000175029 E002 36.6868055 0.0005662983 5.238149e-01 6.574390e-01 10 124988190 124988360 171 - 1.583 1.560 -0.078
ENSG00000175029 E003 21.6694280 0.0362518888 9.299813e-01 9.599325e-01 10 124988361 124988361 1 - 1.345 1.380 0.121
ENSG00000175029 E004 674.7649410 0.0039402916 9.741497e-07 8.101038e-06 10 124988362 124989134 773 - 2.749 2.913 0.544
ENSG00000175029 E005 101.3322812 0.0006306698 2.084109e-05 1.287385e-04 10 124989135 124989160 26 - 1.927 2.096 0.568
ENSG00000175029 E006 167.4651183 0.0002299321 5.819433e-06 4.081424e-05 10 124989161 124989224 64 - 2.160 2.300 0.467
ENSG00000175029 E007 139.4085677 0.0002374571 2.699393e-03 9.372333e-03 10 124989225 124989240 16 - 2.098 2.203 0.352
ENSG00000175029 E008 376.4539818 0.0001736455 2.818231e-03 9.728419e-03 10 124989241 124989385 145 - 2.543 2.613 0.233
ENSG00000175029 E009 381.3003810 0.0001506667 2.764685e-01 4.159377e-01 10 124989386 124989501 116 - 2.565 2.599 0.114
ENSG00000175029 E010 462.3270795 0.0001230324 7.098378e-01 8.071149e-01 10 124989502 124989698 197 - 2.659 2.667 0.026
ENSG00000175029 E011 324.4225136 0.0004496467 4.355472e-02 9.756573e-02 10 124992695 124992812 118 - 2.520 2.489 -0.103
ENSG00000175029 E012 248.9710654 0.0002751437 6.716995e-02 1.386438e-01 10 124993202 124993266 65 - 2.404 2.374 -0.099
ENSG00000175029 E013 179.3060909 0.0002338265 4.068910e-01 5.505234e-01 10 124993267 124993329 63 - 2.256 2.247 -0.029
ENSG00000175029 E014 265.6873518 0.0001702139 6.902229e-01 7.919704e-01 10 124993855 124993985 131 - 2.413 2.436 0.077
ENSG00000175029 E015 257.1802991 0.0001952619 1.677784e-01 2.853089e-01 10 124994469 124994606 138 - 2.390 2.436 0.152
ENSG00000175029 E016 209.0791792 0.0009619003 6.937181e-01 7.947294e-01 10 124994607 124994683 77 - 2.309 2.334 0.084
ENSG00000175029 E017 8.2125917 0.0021493976 4.677398e-01 6.072345e-01 10 124997792 124997963 172 - 0.987 0.916 -0.266
ENSG00000175029 E018 364.7386732 0.0001887905 2.214511e-02 5.597915e-02 10 124997964 124998170 207 - 2.572 2.541 -0.101
ENSG00000175029 E019 345.6961451 0.0001947860 7.598182e-10 1.151746e-08 10 125002960 125003104 145 - 2.579 2.470 -0.365
ENSG00000175029 E020 238.9305762 0.0001820184 1.103901e-08 1.350276e-07 10 125003338 125003463 126 - 2.425 2.302 -0.408
ENSG00000175029 E021 105.1862137 0.0014021150 3.046261e-02 7.286956e-02 10 125003464 125003492 29 - 2.054 1.984 -0.233
ENSG00000175029 E022 1.9185502 0.0081032925 9.931465e-03 2.859141e-02 10 125005547 125006013 467 - 0.242 0.683 2.358
ENSG00000175029 E023 0.5922303 0.0179303189 6.016243e-01 7.227477e-01 10 125026082 125027957 1876 - 0.242 0.154 -0.810
ENSG00000175029 E024 0.0000000       10 125027958 125028071 114 -      
ENSG00000175029 E025 113.9866582 0.0004287432 1.335689e-02 3.675001e-02 10 125038997 125039045 49 - 2.087 2.015 -0.240
ENSG00000175029 E026 136.2447423 0.0024834750 1.812006e-01 3.027339e-01 10 125039046 125039155 110 - 2.150 2.109 -0.136
ENSG00000175029 E027 3.6482112 0.0044109912 4.493847e-02 1.000865e-01 10 125074743 125074843 101 - 0.510 0.815 1.307
ENSG00000175029 E028 6.7378187 0.0404300240 3.278664e-02 7.737950e-02 10 125088191 125088319 129 - 0.718 1.036 1.221
ENSG00000175029 E029 0.8846626 0.0147250791 5.500104e-02 1.179990e-01 10 125100587 125100772 186 - 0.096 0.432 2.777
ENSG00000175029 E030 50.7019571 0.0047387513 2.605382e-01 3.980820e-01 10 125110990 125110996 7 - 1.732 1.675 -0.194
ENSG00000175029 E031 85.4133467 0.0049828542 6.255147e-02 1.309413e-01 10 125110997 125111093 97 - 1.966 1.877 -0.299
ENSG00000175029 E032 0.4815130 0.0220486610 3.157333e-01 4.585045e-01 10 125111759 125111796 38 - 0.096 0.267 1.774
ENSG00000175029 E033 4.1414581 0.0038560702 3.860223e-01 5.302135e-01 10 125122657 125122868 212 - 0.758 0.644 -0.473
ENSG00000175029 E034 4.1050256 0.0038739440 4.691710e-01 6.084629e-01 10 125133512 125133612 101 - 0.738 0.644 -0.394
ENSG00000175029 E035 0.0000000       10 125138007 125138104 98 -      
ENSG00000175029 E036 0.0000000       10 125138211 125138250 40 -      
ENSG00000175029 E037 0.3697384 0.0274424043 9.559250e-02 1.837785e-01 10 125139633 125139694 62 - 0.000 0.268 10.128
ENSG00000175029 E038 4.3253406 0.0037845533 1.612019e-01 2.766684e-01 10 125158635 125158716 82 - 0.794 0.600 -0.809
ENSG00000175029 E039 0.8179419 0.0156821227 9.152452e-01 9.503450e-01 10 125159752 125159856 105 - 0.242 0.268 0.191
ENSG00000175029 E040 3.5125798 0.0047002868 7.605975e-01 8.446505e-01 10 125159857 125160145 289 - 0.627 0.684 0.245
ENSG00000175029 E041 65.2952000 0.0219182322 1.470992e-01 2.577484e-01 10 125160319 125160520 202 - 1.863 1.743 -0.406
ENSG00000175029 E042 43.5273830 0.0005304445 3.221099e-01 4.653997e-01 10 125160827 125161230 404 - 1.665 1.626 -0.133