ENSG00000174939

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000308748 ENSG00000174939 HEK293_OSMI2_2hA HEK293_TMG_2hB ASPHD1 protein_coding protein_coding 3.078451 5.238796 1.611612 0.2893933 0.02818198 -1.694558 1.55334214 2.27957896 0.6438812 0.14149350 0.1021501 -1.807982 0.46004167 0.4358667 0.40156667 -0.0343000 0.863549803 0.005614762 FALSE TRUE
ENST00000414952 ENSG00000174939 HEK293_OSMI2_2hA HEK293_TMG_2hB ASPHD1 protein_coding nonsense_mediated_decay 3.078451 5.238796 1.611612 0.2893933 0.02818198 -1.694558 0.07347185 0.03111727 0.2267810 0.03111727 0.0918318 2.525737 0.06265833 0.0054000 0.13903333 0.1336333 0.005614762 0.005614762 TRUE TRUE
ENST00000483405 ENSG00000174939 HEK293_OSMI2_2hA HEK293_TMG_2hB ASPHD1 protein_coding protein_coding 3.078451 5.238796 1.611612 0.2893933 0.02818198 -1.694558 0.69979379 1.28907915 0.3704224 0.13077161 0.2316366 -1.771815 0.22573333 0.2448333 0.22553333 -0.0193000 0.840976779 0.005614762 FALSE FALSE
ENST00000563177 ENSG00000174939 HEK293_OSMI2_2hA HEK293_TMG_2hB ASPHD1 protein_coding protein_coding 3.078451 5.238796 1.611612 0.2893933 0.02818198 -1.694558 0.58330723 1.43035063 0.1209148 0.19072498 0.1209148 -3.459720 0.14792083 0.2707667 0.07646667 -0.1943000 0.171048126 0.005614762 FALSE FALSE
ENST00000651383 ENSG00000174939 HEK293_OSMI2_2hA HEK293_TMG_2hB ASPHD1 protein_coding protein_coding 3.078451 5.238796 1.611612 0.2893933 0.02818198 -1.694558 0.07576731 0.00000000 0.2496122 0.00000000 0.2496122 4.698286 0.06099167 0.0000000 0.15746667 0.1574667 0.671652703 0.005614762 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000174939 E001 0.2214452 0.0426226220 1.00000000   16 29900365 29900374 10 + 0.000 0.068 7.473
ENSG00000174939 E002 0.2214452 0.0426226220 1.00000000   16 29900375 29900378 4 + 0.000 0.068 9.281
ENSG00000174939 E003 0.7728880 0.0160214720 0.37332112 0.51776833 16 29900379 29900383 5 + 0.000 0.225 11.152
ENSG00000174939 E004 7.9226235 0.0061088947 0.44031910 0.58200102 16 29900384 29900487 104 + 0.930 0.830 -0.385
ENSG00000174939 E005 13.3294478 0.0016831860 0.49225053 0.62943942 16 29900488 29900566 79 + 1.111 1.040 -0.255
ENSG00000174939 E006 18.5931772 0.0015895597 0.38248616 0.52668543 16 29900567 29900741 175 + 1.253 1.177 -0.270
ENSG00000174939 E007 10.1120384 0.0018811597 0.27284511 0.41180112 16 29900742 29900857 116 + 1.042 0.918 -0.463
ENSG00000174939 E008 4.4327393 0.0041803551 0.25238755 0.38873856 16 29900858 29900881 24 + 0.779 0.607 -0.720
ENSG00000174939 E009 6.1246355 0.0029126088 0.02041582 0.05236409 16 29900882 29900920 39 + 0.990 0.689 -1.174
ENSG00000174939 E010 38.1053987 0.0006618625 0.32751138 0.47098065 16 29900921 29901551 631 + 1.534 1.476 -0.200
ENSG00000174939 E011 32.6729562 0.0019335869 0.28947969 0.43015969 16 29901552 29901743 192 + 1.348 1.430 0.282
ENSG00000174939 E012 43.2017097 0.0005670983 0.31804708 0.46097457 16 29901744 29901920 177 + 1.483 1.548 0.221
ENSG00000174939 E013 33.8239168 0.0008021709 0.06760379 0.13937075 16 29904852 29904965 114 + 1.323 1.461 0.476
ENSG00000174939 E014 31.3910740 0.0008330251 0.38658194 0.53075136 16 29905788 29905959 172 + 1.348 1.415 0.232
ENSG00000174939 E015 7.0383768 0.0036086250 0.51722580 0.65165147 16 29905960 29906078 119 + 0.731 0.829 0.390
ENSG00000174939 E016 0.7728880 0.0160214720 0.37332112 0.51776833 16 29906079 29906127 49 + 0.000 0.225 11.152
ENSG00000174939 E017 2.3917193 0.0079180599 0.07173693 0.14623969 16 29919531 29919864 334 + 0.677 0.372 -1.473