ENSG00000174938

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000308713 ENSG00000174938 HEK293_OSMI2_2hA HEK293_TMG_2hB SEZ6L2 protein_coding protein_coding 14.52386 22.50582 9.729749 0.9893458 0.1561699 -1.208983 4.836247 6.344723 3.3375964 0.3386587 0.2154922 -0.9247037 0.33765833 0.2828333 0.34250000 0.05966667 3.527733e-01 8.231666e-10 FALSE TRUE
ENST00000346932 ENSG00000174938 HEK293_OSMI2_2hA HEK293_TMG_2hB SEZ6L2 protein_coding protein_coding 14.52386 22.50582 9.729749 0.9893458 0.1561699 -1.208983 2.154222 4.738486 0.9072621 0.7478305 0.4624810 -2.3720618 0.12865833 0.2108000 0.09303333 -0.11776667 5.732877e-01 8.231666e-10 FALSE TRUE
ENST00000350527 ENSG00000174938 HEK293_OSMI2_2hA HEK293_TMG_2hB SEZ6L2 protein_coding protein_coding 14.52386 22.50582 9.729749 0.9893458 0.1561699 -1.208983 3.805450 7.861067 2.6949926 0.9839749 0.3506792 -1.5409346 0.22792083 0.3488000 0.27690000 -0.07190000 5.730209e-01 8.231666e-10 FALSE TRUE
ENST00000617533 ENSG00000174938 HEK293_OSMI2_2hA HEK293_TMG_2hB SEZ6L2 protein_coding protein_coding 14.52386 22.50582 9.729749 0.9893458 0.1561699 -1.208983 1.702202 0.000000 1.9721474 0.0000000 0.6060678 7.6309205 0.18337083 0.0000000 0.20463333 0.20463333 8.231666e-10 8.231666e-10 FALSE TRUE
MSTRG.12411.8 ENSG00000174938 HEK293_OSMI2_2hA HEK293_TMG_2hB SEZ6L2 protein_coding   14.52386 22.50582 9.729749 0.9893458 0.1561699 -1.208983 1.550037 3.367345 0.6547232 0.4370402 0.4894158 -2.3450640 0.09258333 0.1486000 0.06616667 -0.08243333 4.299503e-01 8.231666e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000174938 E001 1.217768 0.0110910259 6.888684e-02 1.415261e-01 16 29871159 29871160 2 - 0.000 0.382 10.815
ENSG00000174938 E002 62.006604 0.0128761701 4.041650e-06 2.936334e-05 16 29871161 29871316 156 - 1.410 1.803 1.340
ENSG00000174938 E003 57.661874 0.0062729048 8.255335e-05 4.401149e-04 16 29871317 29871335 19 - 1.468 1.758 0.989
ENSG00000174938 E004 361.331740 0.0036635306 1.677936e-07 1.632247e-06 16 29871336 29871728 393 - 2.334 2.532 0.657
ENSG00000174938 E005 265.678761 0.0004988272 2.550985e-07 2.395304e-06 16 29872187 29872283 97 - 2.240 2.389 0.498
ENSG00000174938 E006 302.261415 0.0001868728 1.379779e-06 1.111562e-05 16 29872409 29872526 118 - 2.316 2.440 0.414
ENSG00000174938 E007 133.835460 0.0002651686 1.703569e-03 6.294217e-03 16 29872705 29872743 39 - 1.963 2.085 0.409
ENSG00000174938 E008 320.572111 0.0001580070 1.419989e-01 2.507716e-01 16 29873240 29873431 192 - 2.406 2.447 0.136
ENSG00000174938 E009 345.109615 0.0002338013 3.967564e-02 9.042540e-02 16 29873538 29873729 192 - 2.427 2.480 0.177
ENSG00000174938 E010 124.721294 0.0002968352 7.286495e-01 8.210605e-01 16 29876756 29876764 9 - 2.017 2.037 0.068
ENSG00000174938 E011 192.277907 0.0001879057 2.104189e-02 5.367990e-02 16 29876765 29876853 89 - 2.157 2.233 0.255
ENSG00000174938 E012 206.690378 0.0042196396 2.988953e-02 7.174888e-02 16 29876854 29876950 97 - 2.169 2.269 0.333
ENSG00000174938 E013 219.747317 0.0051900029 4.340004e-01 5.763804e-01 16 29877271 29877467 197 - 2.243 2.284 0.138
ENSG00000174938 E014 104.753226 0.0054218875 2.414585e-03 8.505689e-03 16 29878287 29878425 139 - 2.057 1.912 -0.486
ENSG00000174938 E015 126.535718 0.0059331987 1.426772e-06 1.146106e-05 16 29879864 29880064 201 - 2.193 1.968 -0.755
ENSG00000174938 E016 98.415122 0.0003753606 5.732600e-11 1.053369e-09 16 29885586 29885749 164 - 2.095 1.856 -0.804
ENSG00000174938 E017 0.000000       16 29885750 29886019 270 -      
ENSG00000174938 E018 95.041751 0.0004666887 1.080223e-11 2.238514e-10 16 29887649 29887817 169 - 2.088 1.834 -0.854
ENSG00000174938 E019 99.742489 0.0006504061 2.532005e-08 2.893303e-07 16 29888540 29888725 186 - 2.078 1.871 -0.697
ENSG00000174938 E020 95.104337 0.0003257313 2.193325e-07 2.086462e-06 16 29895259 29895460 202 - 2.049 1.856 -0.648
ENSG00000174938 E021 63.987550 0.0004619331 4.233282e-07 3.799657e-06 16 29895721 29895860 140 - 1.902 1.674 -0.772
ENSG00000174938 E022 39.804836 0.0033949797 1.313831e-04 6.649474e-04 16 29896822 29896911 90 - 1.703 1.467 -0.803
ENSG00000174938 E023 17.703478 0.0010539592 1.978254e-03 7.159414e-03 16 29896912 29896958 47 - 1.382 1.130 -0.888
ENSG00000174938 E024 50.037059 0.0004893750 7.798620e-05 4.185066e-04 16 29896959 29897121 163 - 1.785 1.585 -0.677
ENSG00000174938 E025 65.153021 0.0005220398 1.039402e-06 8.592758e-06 16 29897853 29897984 132 - 1.911 1.693 -0.734
ENSG00000174938 E026 89.141855 0.0040359099 2.002731e-06 1.557710e-05 16 29898941 29899550 610 - 2.047 1.822 -0.755