ENSG00000174915

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000308020 ENSG00000174915 HEK293_OSMI2_2hA HEK293_TMG_2hB PTDSS2 protein_coding protein_coding 70.47038 95.78729 47.56205 3.582311 1.857112 -1.009871 52.231529 74.609966 35.636943 2.57298098 0.6507557 -1.0657833 0.73862083 0.77906667 0.7505 -0.02856667 5.343176e-01 4.548177e-10 FALSE  
MSTRG.4894.11 ENSG00000174915 HEK293_OSMI2_2hA HEK293_TMG_2hB PTDSS2 protein_coding   70.47038 95.78729 47.56205 3.582311 1.857112 -1.009871 3.068358 2.732856 4.285188 0.02951846 0.2569396 0.6470424 0.04859167 0.02866667 0.0908 0.06213333 4.548177e-10 4.548177e-10 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000174915 E001 1.6083596 0.3773168207 8.394110e-01 8.996446e-01 11 448268 448280 13 + 0.290 0.416 0.763
ENSG00000174915 E002 3.8602909 0.1150503136 8.530708e-01 9.089972e-01 11 448281 448419 139 + 0.585 0.652 0.296
ENSG00000174915 E003 0.8857808 0.9250427678 5.967322e-01 7.186322e-01 11 449926 450278 353 + 0.000 0.304 10.573
ENSG00000174915 E004 2.4358257 0.0903153157 9.912444e-01 9.986442e-01 11 450279 450295 17 + 0.462 0.487 0.129
ENSG00000174915 E005 11.1331475 0.0020252029 1.948991e-03 7.068911e-03 11 450296 450326 31 + 1.221 0.924 -1.081
ENSG00000174915 E006 24.3301354 0.0022450845 7.226248e-07 6.187251e-06 11 450327 450344 18 + 1.568 1.222 -1.198
ENSG00000174915 E007 25.6211567 0.0057407039 8.028697e-06 5.450486e-05 11 450345 450346 2 + 1.579 1.252 -1.130
ENSG00000174915 E008 26.4671967 0.0115009808 1.421112e-04 7.125948e-04 11 450347 450353 7 + 1.579 1.276 -1.046
ENSG00000174915 E009 50.7322212 0.0140158610 1.795315e-09 2.537239e-08 11 450354 450419 66 + 1.926 1.492 -1.471
ENSG00000174915 E010 43.7976678 0.0085534344 2.977993e-10 4.850171e-09 11 450420 450423 4 + 1.855 1.438 -1.416
ENSG00000174915 E011 63.0462215 0.0190601300 3.659304e-09 4.884043e-08 11 450424 450450 27 + 2.029 1.576 -1.532
ENSG00000174915 E012 272.4807124 0.0046726995 1.412230e-09 2.037388e-08 11 450451 450637 187 + 2.534 2.315 -0.730
ENSG00000174915 E013 4.1955780 0.0038101920 3.434648e-02 8.042666e-02 11 451352 451384 33 + 0.855 0.567 -1.197
ENSG00000174915 E014 8.7736048 0.0019606226 2.716474e-02 6.633170e-02 11 451385 451493 109 + 1.092 0.861 -0.859
ENSG00000174915 E015 0.9641442 0.0169008503 5.790348e-01 7.040178e-01 11 458674 458860 187 + 0.168 0.278 0.921
ENSG00000174915 E016 6.5902237 0.0025660633 1.654575e-01 2.822996e-01 11 458861 460186 1326 + 0.680 0.887 0.825
ENSG00000174915 E017 433.1601823 0.0001767482 4.302760e-08 4.703121e-07 11 460187 460288 102 + 2.648 2.563 -0.283
ENSG00000174915 E018 5.1615089 0.0247243010 4.396586e-01 5.814101e-01 11 460289 460760 472 + 0.825 0.720 -0.421
ENSG00000174915 E019 10.1902892 0.0078312679 9.550570e-01 9.757857e-01 11 460761 461051 291 + 1.000 1.008 0.028
ENSG00000174915 E020 268.1881562 0.0001875139 8.147689e-01 8.826267e-01 11 473895 473919 25 + 2.372 2.383 0.037
ENSG00000174915 E021 380.2380086 0.0001490517 1.284799e-01 2.320428e-01 11 473920 473977 58 + 2.541 2.528 -0.045
ENSG00000174915 E022 405.4584690 0.0015129969 1.394891e-01 2.473214e-01 11 479085 479152 68 + 2.575 2.554 -0.068
ENSG00000174915 E023 3.3621348 0.0361008859 7.237419e-02 1.472947e-01 11 479153 479445 293 + 0.793 0.509 -1.226
ENSG00000174915 E024 5.9723786 0.0030101772 7.866146e-02 1.573620e-01 11 480125 480594 470 + 0.933 0.720 -0.833
ENSG00000174915 E025 693.2064764 0.0001948113 2.676495e-03 9.302510e-03 11 486939 487073 135 + 2.812 2.784 -0.096
ENSG00000174915 E026 15.0237195 0.0012331600 9.851345e-03 2.839960e-02 11 487239 487419 181 + 1.300 1.086 -0.760
ENSG00000174915 E027 510.7714728 0.0001701057 5.790295e-06 4.062943e-05 11 487420 487470 51 + 2.702 2.641 -0.205
ENSG00000174915 E028 674.9466398 0.0001448942 7.959854e-06 5.408401e-05 11 488199 488312 114 + 2.817 2.766 -0.167
ENSG00000174915 E029 641.0085112 0.0001517663 4.605144e-01 6.005406e-01 11 488529 488647 119 + 2.755 2.761 0.018
ENSG00000174915 E030 12.0805458 0.0062870811 3.368280e-03 1.134620e-02 11 489350 489399 50 + 1.256 0.977 -1.006
ENSG00000174915 E031 541.0558361 0.0003299379 1.569396e-01 2.710178e-01 11 489400 489514 115 + 2.653 2.696 0.144
ENSG00000174915 E032 556.6077765 0.0008795738 8.782369e-05 4.648247e-04 11 489588 489733 146 + 2.621 2.724 0.341
ENSG00000174915 E033 9.3341805 0.0024531375 6.072936e-01 7.273104e-01 11 489791 489882 92 + 1.000 0.957 -0.160
ENSG00000174915 E034 666.3476419 0.0001381099 3.180855e-04 1.453177e-03 11 489883 490068 186 + 2.720 2.794 0.245
ENSG00000174915 E035 839.1251050 0.0007396153 2.316730e-08 2.667584e-07 11 490420 490642 223 + 2.787 2.907 0.401
ENSG00000174915 E036 1273.8688700 0.0024801771 1.042580e-08 1.280394e-07 11 490643 491120 478 + 2.939 3.098 0.529
ENSG00000174915 E037 680.3993208 0.0055816257 8.335198e-03 2.463038e-02 11 491121 491399 279 + 2.696 2.818 0.408