ENSG00000174891

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000295930 ENSG00000174891 HEK293_OSMI2_2hA HEK293_TMG_2hB RSRC1 protein_coding protein_coding 13.81099 5.190184 24.20214 0.3554343 0.6332022 2.219096 5.3051242 1.3552023 9.954922 0.5703586 0.2021349 2.867744 0.3795333 0.24950000 0.4114667 0.1619667 2.824272e-01 5.844711e-14 FALSE TRUE
ENST00000471994 ENSG00000174891 HEK293_OSMI2_2hA HEK293_TMG_2hB RSRC1 protein_coding protein_coding 13.81099 5.190184 24.20214 0.3554343 0.6332022 2.219096 6.0259625 0.3133028 11.784616 0.3133028 0.4420818 5.189099 0.3272375 0.05346667 0.4868000 0.4333333 2.657201e-02 5.844711e-14 FALSE FALSE
ENST00000611884 ENSG00000174891 HEK293_OSMI2_2hA HEK293_TMG_2hB RSRC1 protein_coding protein_coding 13.81099 5.190184 24.20214 0.3554343 0.6332022 2.219096 0.6988088 2.6225800 0.000000 0.5341581 0.0000000 -8.040334 0.1411083 0.52123333 0.0000000 -0.5212333 5.844711e-14 5.844711e-14 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000174891 E001 2.3895558 0.0065849733 2.375560e-03 8.385301e-03 3 158105855 158106010 156 + 0.304 0.822 2.474
ENSG00000174891 E002 0.2214452 0.0388884216 1.320394e-01   3 158107789 158107971 183 + 0.000 0.212 12.875
ENSG00000174891 E003 0.0000000       3 158109939 158110000 62 +      
ENSG00000174891 E004 0.0000000       3 158110001 158110051 51 +      
ENSG00000174891 E005 0.0000000       3 158110052 158110067 16 +      
ENSG00000174891 E006 0.0000000       3 158110068 158110072 5 +      
ENSG00000174891 E007 0.0000000       3 158110073 158110074 2 +      
ENSG00000174891 E008 0.0000000       3 158110075 158110076 2 +      
ENSG00000174891 E009 0.7845438 0.2833889069 4.177673e-01 5.610875e-01 3 158110077 158110088 12 + 0.179 0.350 1.282
ENSG00000174891 E010 10.5886324 0.0016832257 3.538741e-02 8.239766e-02 3 158110089 158110105 17 + 1.053 0.822 -0.871
ENSG00000174891 E011 10.7401479 0.0016266500 3.068546e-02 7.330360e-02 3 158110106 158110106 1 + 1.060 0.822 -0.894
ENSG00000174891 E012 24.2295260 0.0076758988 5.369119e-03 1.693284e-02 3 158110107 158110128 22 + 1.386 1.151 -0.827
ENSG00000174891 E013 36.7877767 0.0031892695 3.979724e-04 1.766511e-03 3 158110129 158110148 20 + 1.560 1.323 -0.817
ENSG00000174891 E014 37.9596536 0.0010080297 7.709982e-05 4.143405e-04 3 158110149 158110155 7 + 1.576 1.323 -0.871
ENSG00000174891 E015 46.7933519 0.0005685388 6.645177e-06 4.600602e-05 3 158110156 158110197 42 + 1.666 1.406 -0.890
ENSG00000174891 E016 41.1661890 0.0011399715 4.732500e-06 3.388096e-05 3 158110198 158110211 14 + 1.617 1.323 -1.010
ENSG00000174891 E017 16.0532409 0.0026256201 1.592684e-01 2.741397e-01 3 158110212 158110223 12 + 1.196 1.089 -0.383
ENSG00000174891 E018 0.1472490 0.0434306724 1.000000e+00   3 158110224 158110386 163 + 0.068 0.000 -10.176
ENSG00000174891 E019 6.2419849 0.0026723087 2.510250e-02 6.208751e-02 3 158110387 158110604 218 + 0.871 0.545 -1.358
ENSG00000174891 E020 64.0822598 0.0003866495 2.838437e-06 2.136151e-05 3 158122103 158122153 51 + 1.794 1.572 -0.751
ENSG00000174891 E021 101.9280274 0.0003451629 3.334075e-04 1.513939e-03 3 158122154 158122298 145 + 1.971 1.860 -0.374
ENSG00000174891 E022 110.1646449 0.0009465961 5.436781e-03 1.711603e-02 3 158123866 158123991 126 + 1.996 1.920 -0.257
ENSG00000174891 E023 0.1451727 0.0431297856 1.000000e+00   3 158132086 158132263 178 + 0.068 0.000 -10.175
ENSG00000174891 E024 0.6717251 0.0278140442 9.237924e-01 9.560081e-01 3 158136745 158136898 154 + 0.178 0.212 0.308
ENSG00000174891 E025 94.9987662 0.0033594035 3.281918e-02 7.744666e-02 3 158203072 158203137 66 + 1.934 1.864 -0.233
ENSG00000174891 E026 102.2479265 0.0003399899 8.944281e-02 1.742813e-01 3 158203138 158203245 108 + 1.955 1.926 -0.098
ENSG00000174891 E027 0.7406253 0.0154585699 2.290579e-01 3.613033e-01 3 158203246 158203269 24 + 0.266 0.000 -12.410
ENSG00000174891 E028 0.3666179 0.0296985309 3.724358e-01 5.169037e-01 3 158203270 158210341 7072 + 0.068 0.212 1.894
ENSG00000174891 E029 0.9620705 0.0121989077 7.201148e-01 8.147805e-01 3 158218690 158221417 2728 + 0.266 0.211 -0.430
ENSG00000174891 E030 1.5166363 0.0089855916 8.293712e-01 8.928648e-01 3 158225657 158225733 77 + 0.371 0.353 -0.110
ENSG00000174891 E031 0.1515154 0.0428843273 1.000000e+00   3 158231170 158231278 109 + 0.068 0.000 -10.176
ENSG00000174891 E032 65.1241238 0.0004859458 3.675066e-01 5.118910e-01 3 158298039 158298075 37 + 1.733 1.817 0.283
ENSG00000174891 E033 0.9222159 0.2799969862 8.385511e-01 8.990740e-01 3 158302682 158303575 894 + 0.266 0.212 -0.427
ENSG00000174891 E034 0.0000000       3 158330292 158330387 96 +      
ENSG00000174891 E035 73.7441434 0.0004077748 3.975886e-01 5.413428e-01 3 158354857 158354908 52 + 1.785 1.864 0.265
ENSG00000174891 E036 0.0000000       3 158354909 158354951 43 +      
ENSG00000174891 E037 81.6360339 0.0003167767 3.115236e-02 7.419721e-02 3 158460935 158461003 69 + 1.817 1.948 0.442
ENSG00000174891 E038 3.1042465 0.0049674737 4.657752e-01 6.053975e-01 3 158461004 158461009 6 + 0.527 0.677 0.668
ENSG00000174891 E039 0.2214452 0.0388884216 1.320394e-01   3 158461010 158461856 847 + 0.000 0.212 12.875
ENSG00000174891 E040 0.7363589 0.0155158474 2.290544e-01 3.613008e-01 3 158461857 158463250 1394 + 0.266 0.000 -12.410
ENSG00000174891 E041 0.2214452 0.0388884216 1.320394e-01   3 158469344 158469732 389 + 0.000 0.212 12.875
ENSG00000174891 E042 96.5385360 0.0003991202 6.096837e-02 1.282651e-01 3 158537092 158537198 107 + 1.894 2.008 0.382
ENSG00000174891 E043 105.9859554 0.0004051198 6.223533e-02 1.304034e-01 3 158543335 158543487 153 + 1.936 2.046 0.370
ENSG00000174891 E044 1.7566186 0.3031376092 7.126335e-01 8.093077e-01 3 158543488 158543511 24 + 0.428 0.346 -0.465
ENSG00000174891 E045 8.1663828 0.0268811011 2.944891e-01 4.355771e-01 3 158543512 158544182 671 + 0.860 1.040 0.674
ENSG00000174891 E046 284.8834212 0.0060778799 9.842947e-12 2.052975e-10 3 158544183 158545730 1548 + 2.303 2.591 0.961