ENSG00000174842

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000370360 ENSG00000174842 HEK293_OSMI2_2hA HEK293_TMG_2hB GLMN protein_coding protein_coding 21.58949 9.137714 30.57792 0.9350452 1.269286 1.741479 10.4010467 4.4617364 16.4267154 0.3804415 2.19093944 1.8780150 0.46230417 0.50883333 0.53390000 0.02506667 0.95268350 0.02649634 FALSE TRUE
ENST00000471465 ENSG00000174842 HEK293_OSMI2_2hA HEK293_TMG_2hB GLMN protein_coding retained_intron 21.58949 9.137714 30.57792 0.9350452 1.269286 1.741479 1.8570518 0.8306297 1.0124648 0.1970396 0.27489184 0.2825088 0.11132500 0.08826667 0.03296667 -0.05530000 0.02649634 0.02649634   FALSE
ENST00000495852 ENSG00000174842 HEK293_OSMI2_2hA HEK293_TMG_2hB GLMN protein_coding protein_coding 21.58949 9.137714 30.57792 0.9350452 1.269286 1.741479 1.3910317 1.1742186 0.0000000 0.6589330 0.00000000 -6.8877916 0.08937083 0.13026667 0.00000000 -0.13026667 0.09473257 0.02649634 FALSE TRUE
MSTRG.1598.11 ENSG00000174842 HEK293_OSMI2_2hA HEK293_TMG_2hB GLMN protein_coding   21.58949 9.137714 30.57792 0.9350452 1.269286 1.741479 2.3611907 1.1761686 3.4922674 0.6050915 0.98780070 1.5619802 0.09693750 0.11656667 0.11516667 -0.00140000 0.92027190 0.02649634 FALSE TRUE
MSTRG.1598.2 ENSG00000174842 HEK293_OSMI2_2hA HEK293_TMG_2hB GLMN protein_coding   21.58949 9.137714 30.57792 0.9350452 1.269286 1.741479 0.8186202 0.7877144 0.4199021 0.5139302 0.03508207 -0.8918641 0.05423750 0.08503333 0.01376667 -0.07126667 0.22197078 0.02649634 FALSE TRUE
MSTRG.1598.7 ENSG00000174842 HEK293_OSMI2_2hA HEK293_TMG_2hB GLMN protein_coding   21.58949 9.137714 30.57792 0.9350452 1.269286 1.741479 2.8982093 0.2163624 6.3521997 0.2163624 0.61002917 4.8128195 0.10956667 0.02213333 0.20986667 0.18773333 0.03823978 0.02649634 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000174842 E001 0.6986918 0.0172671820 3.215882e-02 7.616346e-02 1 92246402 92246413 12 - 0.073 0.439 3.266
ENSG00000174842 E002 1.6522400 0.1204103027 2.688713e-03 9.340044e-03 1 92246414 92246436 23 - 0.135 0.712 3.516
ENSG00000174842 E003 1.6522400 0.1204103027 2.688713e-03 9.340044e-03 1 92246437 92246467 31 - 0.135 0.712 3.516
ENSG00000174842 E004 2.1746397 0.0340011229 2.698016e-03 9.367894e-03 1 92246468 92246474 7 - 0.237 0.756 2.693
ENSG00000174842 E005 3.2022864 0.0050507940 1.655371e-03 6.138768e-03 1 92246475 92246489 15 - 0.390 0.870 2.142
ENSG00000174842 E006 2.8034032 0.0057460556 1.040604e-02 2.976092e-02 1 92246490 92246491 2 - 0.390 0.796 1.851
ENSG00000174842 E007 3.6203009 0.0043338556 2.754215e-02 6.709588e-02 1 92246492 92246496 5 - 0.503 0.834 1.419
ENSG00000174842 E008 74.0320969 0.0003316823 2.989292e-12 6.786048e-11 1 92246497 92246646 150 - 1.726 2.020 0.992
ENSG00000174842 E009 112.1892495 0.0003660993 1.107938e-17 5.409681e-16 1 92247062 92247144 83 - 1.905 2.201 0.991
ENSG00000174842 E010 149.2588313 0.0012376671 1.125818e-08 1.374776e-07 1 92247878 92247989 112 - 2.069 2.261 0.641
ENSG00000174842 E011 12.5282874 0.0342486335 5.233312e-03 1.656700e-02 1 92247990 92248408 419 - 0.955 1.307 1.265
ENSG00000174842 E012 74.8033052 0.0044812482 1.049412e-01 1.980024e-01 1 92262863 92262864 2 - 1.806 1.897 0.304
ENSG00000174842 E013 114.0990780 0.0003130176 2.052606e-02 5.259628e-02 1 92262865 92262926 62 - 1.990 2.072 0.277
ENSG00000174842 E014 145.6847731 0.0002366964 1.405356e-02 3.834550e-02 1 92263623 92263732 110 - 2.097 2.173 0.256
ENSG00000174842 E015 129.1232421 0.0011280972 8.068213e-02 1.606138e-01 1 92264554 92264638 85 - 2.048 2.109 0.206
ENSG00000174842 E016 114.0795269 0.0003878598 2.918548e-01 4.327657e-01 1 92266419 92266492 74 - 2.000 2.037 0.123
ENSG00000174842 E017 4.2177426 0.0044183323 5.465219e-02 1.173941e-01 1 92266540 92266593 54 - 0.592 0.869 1.139
ENSG00000174842 E018 76.3345217 0.0028628200 3.849229e-01 5.290717e-01 1 92266700 92266741 42 - 1.827 1.866 0.130
ENSG00000174842 E019 117.4801598 0.0002974336 1.752316e-01 2.949779e-01 1 92267913 92268002 90 - 2.038 1.985 -0.178
ENSG00000174842 E020 80.0943489 0.0003743919 3.901885e-01 5.342000e-01 1 92268105 92268135 31 - 1.870 1.829 -0.137
ENSG00000174842 E021 108.5263791 0.0002569594 5.836024e-01 7.076902e-01 1 92269723 92269776 54 - 1.997 1.974 -0.076
ENSG00000174842 E022 189.2824532 0.0002117016 2.283033e-03 8.099054e-03 1 92271465 92271652 188 - 2.253 2.161 -0.308
ENSG00000174842 E023 124.9560910 0.0003086242 1.072131e-03 4.208356e-03 1 92286490 92286592 103 - 2.080 1.955 -0.418
ENSG00000174842 E024 187.2385488 0.0054104707 4.591238e-04 2.002985e-03 1 92288914 92289151 238 - 2.263 2.098 -0.552
ENSG00000174842 E025 104.4046413 0.0015587888 1.932709e-07 1.857195e-06 1 92290198 92290306 109 - 2.027 1.782 -0.826
ENSG00000174842 E026 2.5246886 0.0080591460 5.027758e-01 6.387773e-01 1 92290307 92290330 24 - 0.477 0.593 0.543
ENSG00000174842 E027 93.7730844 0.0003027096 2.630623e-07 2.463245e-06 1 92291418 92291537 120 - 1.981 1.746 -0.789
ENSG00000174842 E028 97.3563101 0.0014025767 1.913346e-05 1.192282e-04 1 92297404 92297520 117 - 1.992 1.789 -0.682
ENSG00000174842 E029 58.2068902 0.0006107728 1.508945e-04 7.510437e-04 1 92297521 92297529 9 - 1.775 1.556 -0.743
ENSG00000174842 E030 0.8148214 0.0183228510 8.680644e-01 9.191330e-01 1 92297530 92297960 431 - 0.237 0.200 -0.317
ENSG00000174842 E031 75.8581992 0.0004171090 9.681699e-05 5.071440e-04 1 92297961 92298029 69 - 1.883 1.688 -0.658
ENSG00000174842 E032 11.5960654 0.0070146163 1.035460e-01 1.959007e-01 1 92298486 92298924 439 - 1.101 0.903 -0.734
ENSG00000174842 E033 46.2919569 0.0004914081 4.512349e-02 1.004242e-01 1 92298925 92299002 78 - 1.658 1.534 -0.423