ENSG00000174839

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000311128 ENSG00000174839 HEK293_OSMI2_2hA HEK293_TMG_2hB DENND6A protein_coding protein_coding 16.49466 5.274165 26.11709 1.160539 0.9509433 2.305799 11.8704509 4.4896603 18.5567950 1.1057850 0.7242863 2.044837 0.7754333 0.84773333 0.710733333 -0.13700000 1.934964e-01 9.129535e-06 FALSE TRUE
ENST00000471531 ENSG00000174839 HEK293_OSMI2_2hA HEK293_TMG_2hB DENND6A protein_coding protein_coding 16.49466 5.274165 26.11709 1.160539 0.9509433 2.305799 0.4666784 0.3414434 0.1282977 0.1924925 0.1282977 -1.345516 0.0402000 0.06436667 0.005233333 -0.05913333 2.952358e-01 9.129535e-06 FALSE FALSE
MSTRG.23144.6 ENSG00000174839 HEK293_OSMI2_2hA HEK293_TMG_2hB DENND6A protein_coding   16.49466 5.274165 26.11709 1.160539 0.9509433 2.305799 1.9451884 0.1378213 4.1008901 0.0263390 0.4851420 4.797525 0.0791875 0.02956667 0.157366667 0.12780000 9.129535e-06 9.129535e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000174839 E001 428.4412989 0.0114098591 1.075584e-13 3.042193e-12 3 57625454 57626402 949 - 2.403 2.836 1.443
ENSG00000174839 E002 53.7508471 0.0004714822 3.262250e-03 1.103889e-02 3 57626403 57626420 18 - 1.577 1.820 0.826
ENSG00000174839 E003 28.4206272 0.0008874226 1.556712e-04 7.723710e-04 3 57626421 57626432 12 - 1.279 1.632 1.215
ENSG00000174839 E004 13.7572007 0.0651015249 1.752856e-02 4.610143e-02 3 57626433 57626449 17 - 0.931 1.429 1.781
ENSG00000174839 E005 196.7620142 0.0014034793 1.110094e-08 1.357062e-07 3 57626450 57627437 988 - 2.123 2.392 0.898
ENSG00000174839 E006 96.3439721 0.0003405118 2.523903e-05 1.528648e-04 3 57627438 57627814 377 - 1.819 2.075 0.858
ENSG00000174839 E007 123.3612571 0.0003059624 2.638271e-02 6.471574e-02 3 57627815 57628085 271 - 1.982 1.970 -0.043
ENSG00000174839 E008 198.8302293 0.0002117687 3.158720e-09 4.267651e-08 3 57628086 57628345 260 - 2.205 2.081 -0.415
ENSG00000174839 E009 115.1080304 0.0006526859 1.105622e-06 9.094423e-06 3 57628811 57628885 75 - 1.972 1.820 -0.511
ENSG00000174839 E010 1.7263515 0.0093907450 6.266829e-03 1.931132e-02 3 57630349 57630420 72 - 0.226 0.752 2.767
ENSG00000174839 E011 113.8140421 0.0030485396 1.306796e-04 6.617522e-04 3 57630421 57630523 103 - 1.964 1.835 -0.437
ENSG00000174839 E012 74.6080226 0.0003336490 2.469056e-02 6.124696e-02 3 57630715 57630738 24 - 1.772 1.730 -0.141
ENSG00000174839 E013 94.6067167 0.0010453646 2.844307e-02 6.889725e-02 3 57630739 57630824 86 - 1.871 1.840 -0.105
ENSG00000174839 E014 69.4445922 0.0010507648 3.549642e-02 8.260985e-02 3 57630925 57630978 54 - 1.741 1.697 -0.147
ENSG00000174839 E015 0.5244761 0.2960982461 4.598334e-01 5.999096e-01 3 57630979 57631184 206 - 0.105 0.253 1.529
ENSG00000174839 E016 72.0055806 0.0022885441 1.144616e-02 3.222579e-02 3 57633265 57633354 90 - 1.761 1.684 -0.262
ENSG00000174839 E017 68.5498645 0.0004356365 6.452917e-02 1.342624e-01 3 57634558 57634622 65 - 1.730 1.705 -0.086
ENSG00000174839 E018 72.0932842 0.0006077510 8.306150e-03 2.456002e-02 3 57634704 57634769 66 - 1.761 1.691 -0.237
ENSG00000174839 E019 92.1471813 0.0003525101 9.877378e-03 2.846382e-02 3 57641653 57641747 95 - 1.862 1.815 -0.158
ENSG00000174839 E020 76.1755988 0.0003727528 4.648103e-02 1.029051e-01 3 57645661 57645756 96 - 1.776 1.749 -0.092
ENSG00000174839 E021 76.3694024 0.0003217865 6.324386e-03 1.946812e-02 3 57646316 57646438 123 - 1.786 1.717 -0.231
ENSG00000174839 E022 0.1482932 0.0411597534 8.237194e-02   3 57657651 57657679 29 - 0.000 0.249 11.607
ENSG00000174839 E023 68.9929455 0.0009220200 7.710902e-04 3.153968e-03 3 57657680 57657735 56 - 1.753 1.632 -0.409
ENSG00000174839 E024 77.1880534 0.0034862456 8.192561e-05 4.370881e-04 3 57659118 57659180 63 - 1.806 1.631 -0.592
ENSG00000174839 E025 91.5520708 0.0003458386 4.374718e-06 3.154602e-05 3 57660760 57660839 80 - 1.877 1.717 -0.537
ENSG00000174839 E026 99.4639862 0.0003233031 7.020643e-07 6.026187e-06 3 57661446 57661551 106 - 1.912 1.743 -0.572
ENSG00000174839 E027 71.5099162 0.0006810478 3.190507e-05 1.886021e-04 3 57663636 57663713 78 - 1.770 1.600 -0.578
ENSG00000174839 E028 30.9802483 0.0216230501 3.410708e-01 4.849841e-01 3 57663714 57663716 3 - 1.399 1.354 -0.156
ENSG00000174839 E029 4.6168293 0.0046928221 7.833640e-02 1.568077e-01 3 57665961 57666122 162 - 0.572 0.902 1.355
ENSG00000174839 E030 70.4427404 0.0030067916 1.124116e-01 2.090533e-01 3 57666123 57666235 113 - 1.742 1.717 -0.083
ENSG00000174839 E031 41.8979683 0.0006410847 1.204122e-03 4.654601e-03 3 57672256 57672298 43 - 1.542 1.371 -0.590
ENSG00000174839 E032 43.2311732 0.0027067618 1.000038e-02 2.876359e-02 3 57672400 57672438 39 - 1.551 1.425 -0.432
ENSG00000174839 E033 17.6438771 0.0012560636 1.399846e-02 3.822434e-02 3 57679487 57679725 239 - 1.190 0.979 -0.762
ENSG00000174839 E034 73.4254507 0.0017891999 3.077451e-03 1.049379e-02 3 57692782 57693117 336 - 1.772 1.670 -0.346