ENSG00000174799

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000257287 ENSG00000174799 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP135 protein_coding protein_coding 6.925778 2.288364 10.53297 0.3281196 0.2775928 2.197603 3.0805476 0.1766885 5.9978342 0.1766885 0.1534992 5.0081397 0.33702917 0.09246667 0.57040000 0.47793333 0.04078732 0.04078732 FALSE TRUE
ENST00000515081 ENSG00000174799 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP135 protein_coding retained_intron 6.925778 2.288364 10.53297 0.3281196 0.2775928 2.197603 1.5744244 0.7122413 1.9056313 0.1210975 0.2476508 1.4072671 0.23965833 0.32020000 0.18026667 -0.13993333 0.18514213 0.04078732 FALSE TRUE
MSTRG.24914.1 ENSG00000174799 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP135 protein_coding   6.925778 2.288364 10.53297 0.3281196 0.2775928 2.197603 0.9501745 0.4165945 1.0957332 0.2345411 0.2433486 1.3740660 0.15123333 0.16840000 0.10516667 -0.06323333 0.93655599 0.04078732 FALSE TRUE
MSTRG.24914.2 ENSG00000174799 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP135 protein_coding   6.925778 2.288364 10.53297 0.3281196 0.2775928 2.197603 0.7265376 0.7508227 0.8273029 0.4443542 0.5801585 0.1381893 0.13070417 0.33570000 0.07823333 -0.25746667 0.73985881 0.04078732 FALSE TRUE
MSTRG.24914.8 ENSG00000174799 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP135 protein_coding   6.925778 2.288364 10.53297 0.3281196 0.2775928 2.197603 0.3647580 0.1769459 0.3805914 0.1769459 0.1224216 1.0630394 0.09992917 0.06013333 0.03570000 -0.02443333 0.84959576 0.04078732 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000174799 E001 0.8126314 0.0153787590 7.525727e-01 8.387218e-01 4 55948765 55948838 74 + 0.187 0.252 0.548
ENSG00000174799 E002 3.2035235 0.0083769243 2.462932e-01 3.816072e-01 4 55948839 55948870 32 + 0.480 0.694 0.964
ENSG00000174799 E003 7.3334181 0.0022461128 6.899740e-01 7.917856e-01 4 55948871 55948944 74 + 0.796 0.863 0.262
ENSG00000174799 E004 20.9620437 0.0082746214 4.363980e-01 5.784828e-01 4 55948945 55949059 115 + 1.238 1.158 -0.282
ENSG00000174799 E005 33.1840159 0.0049990249 8.310149e-01 8.940552e-01 4 55952086 55952243 158 + 1.416 1.405 -0.036
ENSG00000174799 E006 0.0000000       4 55952244 55952553 310 +      
ENSG00000174799 E007 14.8529248 0.0024903756 6.824027e-01 7.858484e-01 4 55953085 55953092 8 + 1.090 1.050 -0.145
ENSG00000174799 E008 46.4507334 0.0012489408 3.815446e-02 8.764488e-02 4 55953093 55953275 183 + 1.577 1.431 -0.501
ENSG00000174799 E009 29.4782507 0.0750071938 6.183086e-01 7.359961e-01 4 55954216 55954277 62 + 1.368 1.342 -0.089
ENSG00000174799 E010 37.1224643 0.0006137052 8.404974e-01 9.004524e-01 4 55954278 55954383 106 + 1.454 1.479 0.084
ENSG00000174799 E011 30.5188311 0.0006990425 3.762580e-01 5.206067e-01 4 55957223 55957275 53 + 1.363 1.443 0.276
ENSG00000174799 E012 42.6474595 0.0006871746 7.954933e-01 8.694090e-01 4 55957276 55957364 89 + 1.521 1.511 -0.033
ENSG00000174799 E013 35.1482006 0.0007227670 9.650558e-01 9.820060e-01 4 55959682 55959766 85 + 1.438 1.443 0.019
ENSG00000174799 E014 3.3554323 0.1530052477 6.841184e-01 7.871639e-01 4 55959767 55960925 1159 + 0.536 0.613 0.350
ENSG00000174799 E015 46.9425747 0.0021180807 4.416687e-01 5.833094e-01 4 55964274 55964402 129 + 1.569 1.522 -0.162
ENSG00000174799 E016 0.5202097 0.0201636361 3.960168e-01 5.397983e-01 4 55964866 55965643 778 + 0.104 0.252 1.548
ENSG00000174799 E017 62.8581681 0.0004354136 5.420509e-01 6.729132e-01 4 55965644 55965859 216 + 1.688 1.661 -0.092
ENSG00000174799 E018 30.8936540 0.0393322454 3.142007e-06 2.339979e-05 4 55965860 55966580 721 + 1.232 1.769 1.845
ENSG00000174799 E019 17.5335280 0.0043349606 2.122697e-02 5.406759e-02 4 55969063 55969066 4 + 1.192 0.907 -1.040
ENSG00000174799 E020 33.5276857 0.0006190728 8.337517e-02 1.648542e-01 4 55969067 55969128 62 + 1.438 1.298 -0.483
ENSG00000174799 E021 48.5552865 0.0004855173 9.647122e-04 3.837760e-03 4 55971270 55971408 139 + 1.604 1.362 -0.831
ENSG00000174799 E022 50.1990461 0.0014247854 2.395632e-05 1.459732e-04 4 55974746 55974969 224 + 1.628 1.299 -1.134
ENSG00000174799 E023 34.8791769 0.0017048960 3.754490e-06 2.750171e-05 4 55980143 55980295 153 + 1.484 1.019 -1.642
ENSG00000174799 E024 38.6295015 0.0049277931 2.785850e-03 9.632088e-03 4 55981227 55981379 153 + 1.510 1.245 -0.923
ENSG00000174799 E025 32.8126756 0.0006641726 7.068278e-03 2.140311e-02 4 55985281 55985358 78 + 1.440 1.203 -0.828
ENSG00000174799 E026 39.9105061 0.0009473294 1.777823e-02 4.665963e-02 4 55991934 55992085 152 + 1.516 1.332 -0.635
ENSG00000174799 E027 40.2085454 0.0005193658 2.090800e-01 3.374331e-01 4 55999302 55999417 116 + 1.505 1.418 -0.299
ENSG00000174799 E028 48.1786193 0.0021256453 1.655547e-01 2.824325e-01 4 55999491 55999645 155 + 1.582 1.491 -0.311
ENSG00000174799 E029 26.4302095 0.0008857587 2.117563e-01 3.405513e-01 4 56008327 56008382 56 + 1.289 1.405 0.404
ENSG00000174799 E030 48.1117784 0.0005238140 2.806745e-01 4.205421e-01 4 56009735 56009903 169 + 1.577 1.512 -0.224
ENSG00000174799 E031 41.2769238 0.0471728839 9.936786e-02 1.895249e-01 4 56011412 56011522 111 + 1.525 1.365 -0.553
ENSG00000174799 E032 48.1781287 0.0128223785 7.148758e-01 8.109451e-01 4 56011800 56011985 186 + 1.567 1.558 -0.031
ENSG00000174799 E033 63.8901853 0.0004306776 8.076856e-01 8.778045e-01 4 56017648 56017857 210 + 1.680 1.704 0.082
ENSG00000174799 E034 63.3271776 0.0004239178 5.572828e-01 6.857258e-01 4 56019353 56019555 203 + 1.674 1.717 0.147
ENSG00000174799 E035 48.3281632 0.0008564290 3.762926e-01 5.206310e-01 4 56020676 56020780 105 + 1.555 1.623 0.231
ENSG00000174799 E036 40.3540947 0.0005790301 5.781425e-01 7.032988e-01 4 56024501 56024614 114 + 1.499 1.467 -0.110
ENSG00000174799 E037 175.3858077 0.0008222374 7.839321e-24 7.638006e-22 4 56031360 56033361 2002 + 2.044 2.367 1.080