ENSG00000174796

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000311638 ENSG00000174796 HEK293_OSMI2_2hA HEK293_TMG_2hB THAP6 protein_coding protein_coding 5.886461 2.910169 7.50177 0.3959572 0.3449103 1.363101 2.18644968 0.6273022 3.08789897 0.11938776 0.13593971 2.2812405 0.32708333 0.22983333 0.411766667 0.181933333 0.093825802 0.001293094 FALSE TRUE
ENST00000507556 ENSG00000174796 HEK293_OSMI2_2hA HEK293_TMG_2hB THAP6 protein_coding protein_coding 5.886461 2.910169 7.50177 0.3959572 0.3449103 1.363101 0.55333078 0.1914347 0.81525526 0.08390122 0.13498222 2.0345283 0.09953750 0.06256667 0.108933333 0.046366667 0.500902979 0.001293094 FALSE TRUE
ENST00000507557 ENSG00000174796 HEK293_OSMI2_2hA HEK293_TMG_2hB THAP6 protein_coding protein_coding 5.886461 2.910169 7.50177 0.3959572 0.3449103 1.363101 0.12601052 0.2895901 0.07973671 0.14489923 0.07973671 -1.7392200 0.02655833 0.08913333 0.011500000 -0.077633333 0.381337458 0.001293094   FALSE
ENST00000514480 ENSG00000174796 HEK293_OSMI2_2hA HEK293_TMG_2hB THAP6 protein_coding protein_coding 5.886461 2.910169 7.50177 0.3959572 0.3449103 1.363101 0.51067243 0.1817857 0.69432255 0.04284803 0.04895944 1.8767412 0.07353750 0.06103333 0.092433333 0.031400000 0.451682541 0.001293094 FALSE TRUE
MSTRG.25027.10 ENSG00000174796 HEK293_OSMI2_2hA HEK293_TMG_2hB THAP6 protein_coding   5.886461 2.910169 7.50177 0.3959572 0.3449103 1.363101 0.31514894 0.0000000 0.06217793 0.00000000 0.06217793 2.8515578 0.05320000 0.00000000 0.008366667 0.008366667 0.964902124 0.001293094 FALSE TRUE
MSTRG.25027.3 ENSG00000174796 HEK293_OSMI2_2hA HEK293_TMG_2hB THAP6 protein_coding   5.886461 2.910169 7.50177 0.3959572 0.3449103 1.363101 0.84515231 0.6340927 0.94835951 0.24075588 0.21349773 0.5732985 0.16604583 0.22706667 0.124533333 -0.102533333 0.664754399 0.001293094 TRUE TRUE
MSTRG.25027.6 ENSG00000174796 HEK293_OSMI2_2hA HEK293_TMG_2hB THAP6 protein_coding   5.886461 2.910169 7.50177 0.3959572 0.3449103 1.363101 0.13229336 0.0000000 0.58777088 0.00000000 0.21163563 5.9015207 0.01817500 0.00000000 0.076100000 0.076100000 0.001293094 0.001293094 TRUE TRUE
MSTRG.25027.7 ENSG00000174796 HEK293_OSMI2_2hA HEK293_TMG_2hB THAP6 protein_coding   5.886461 2.910169 7.50177 0.3959572 0.3449103 1.363101 0.09167878 0.1665103 0.00000000 0.16651034 0.00000000 -4.1416808 0.02861667 0.05590000 0.000000000 -0.055900000 0.622844864 0.001293094 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000174796 E001 0.0000000       4 75513946 75513998 53 +      
ENSG00000174796 E002 0.1472490 0.0448846422 1.000000e+00   4 75514218 75514437 220 + 0.078 0.000 -8.546
ENSG00000174796 E003 0.0000000       4 75514438 75514443 6 +      
ENSG00000174796 E004 0.1451727 0.0427968222 1.000000e+00   4 75514444 75514453 10 + 0.078 0.000 -10.833
ENSG00000174796 E005 2.5496953 0.0072578181 6.774772e-01 7.821827e-01 4 75514454 75514472 19 + 0.551 0.498 -0.249
ENSG00000174796 E006 3.6139753 0.0147445995 7.479238e-01 8.353393e-01 4 75514473 75514478 6 + 0.657 0.625 -0.136
ENSG00000174796 E007 8.1269592 0.0158491103 4.176228e-01 5.609480e-01 4 75514479 75514487 9 + 0.957 0.872 -0.320
ENSG00000174796 E008 9.2801972 0.0021767118 5.981771e-01 7.198301e-01 4 75514488 75514488 1 + 0.993 0.958 -0.132
ENSG00000174796 E009 9.5789617 0.0018938892 4.953144e-01 6.321340e-01 4 75514489 75514490 2 + 1.010 0.958 -0.195
ENSG00000174796 E010 10.3205174 0.0017749005 4.413675e-01 5.830075e-01 4 75514491 75514493 3 + 1.043 0.983 -0.220
ENSG00000174796 E011 16.3067063 0.0011598766 7.979676e-01 8.710907e-01 4 75514494 75514519 26 + 1.203 1.206 0.013
ENSG00000174796 E012 16.3067063 0.0011598766 7.979676e-01 8.710907e-01 4 75514520 75514520 1 + 1.203 1.206 0.013
ENSG00000174796 E013 4.7994772 0.0038128969 3.114004e-01 4.538513e-01 4 75514521 75514869 349 + 0.676 0.840 0.664
ENSG00000174796 E014 4.5372339 0.0036779200 7.265826e-01 8.195581e-01 4 75514870 75514991 122 + 0.693 0.767 0.301
ENSG00000174796 E015 30.1618977 0.0006881477 3.871492e-02 8.865519e-02 4 75515433 75515532 100 + 1.490 1.373 -0.403
ENSG00000174796 E016 49.2969233 0.0021956677 5.970932e-01 7.189140e-01 4 75516772 75516979 208 + 1.663 1.661 -0.009
ENSG00000174796 E017 1.0632334 0.0153930648 5.232074e-02 1.132905e-01 4 75516980 75517720 741 + 0.144 0.499 2.455
ENSG00000174796 E018 32.3238992 0.0007321310 8.509268e-01 9.075759e-01 4 75521736 75521861 126 + 1.479 1.494 0.051
ENSG00000174796 E019 2.6340066 0.1374286548 5.139857e-01 6.487558e-01 4 75521862 75522582 721 + 0.471 0.633 0.751
ENSG00000174796 E020 39.8837781 0.0005495421 9.232915e-07 7.718419e-06 4 75526960 75527429 470 + 1.644 1.353 -1.000
ENSG00000174796 E021 20.3596847 0.0373440893 3.797141e-03 1.257415e-02 4 75527430 75527598 169 + 1.373 1.013 -1.281
ENSG00000174796 E022 111.6295354 0.0005298785 1.166712e-04 5.986082e-04 4 75527599 75530026 2428 + 2.046 1.943 -0.346
ENSG00000174796 E023 7.2532674 0.0023441162 7.673521e-01 8.496102e-01 4 75539859 75539959 101 + 0.886 0.873 -0.049
ENSG00000174796 E024 12.1359602 0.0028615393 2.841404e-02 6.884454e-02 4 75542409 75542486 78 + 0.994 1.235 0.869
ENSG00000174796 E025 9.7819900 0.0269174118 7.543318e-02 1.522138e-01 4 75542487 75542552 66 + 0.897 1.149 0.925
ENSG00000174796 E026 14.7446785 0.0013706721 9.594231e-01 9.785343e-01 4 75542553 75543055 503 + 1.146 1.176 0.110
ENSG00000174796 E027 24.6714040 0.0017131959 2.776832e-12 6.340394e-11 4 75544328 75544692 365 + 1.139 1.655 1.789
ENSG00000174796 E028 27.4193689 0.0575343288 1.497329e-06 1.197857e-05 4 75546974 75547198 225 + 1.101 1.765 2.300
ENSG00000174796 E029 0.0000000       4 75549605 75549720 116 +      
ENSG00000174796 E030 0.1515154 0.0423671959 1.000000e+00   4 75550336 75550473 138 + 0.078 0.000 -10.835