ENSG00000174780

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000504757 ENSG00000174780 HEK293_OSMI2_2hA HEK293_TMG_2hB SRP72 protein_coding protein_coding 53.77635 13.56482 95.60644 1.336303 1.51386 2.816326 9.9836201 0.4357191 17.81148771 0.1104410 2.23118321 5.321339 0.12280000 0.03176667 0.1870000000 0.15523333 8.346239e-07 8.346239e-07 FALSE TRUE
ENST00000507126 ENSG00000174780 HEK293_OSMI2_2hA HEK293_TMG_2hB SRP72 protein_coding retained_intron 53.77635 13.56482 95.60644 1.336303 1.51386 2.816326 0.2402979 1.1175181 0.09228056 1.1175181 0.04855293 -3.462547 0.01448333 0.06973333 0.0009666667 -0.06876667 8.697314e-01 8.346239e-07 FALSE FALSE
ENST00000642900 ENSG00000174780 HEK293_OSMI2_2hA HEK293_TMG_2hB SRP72 protein_coding protein_coding 53.77635 13.56482 95.60644 1.336303 1.51386 2.816326 39.4340321 11.4956797 70.30775291 0.4094407 2.41705653 2.611543 0.79654583 0.85953333 0.7349666667 -0.12456667 2.562976e-01 8.346239e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000174780 E001 9.676030 0.0191221847 1.217526e-01 2.224269e-01 4 56467617 56467617 1 + 0.929 0.718 -0.824
ENSG00000174780 E002 240.184297 0.0003261254 4.332013e-10 6.861931e-09 4 56467618 56467735 118 + 2.259 2.099 -0.537
ENSG00000174780 E003 179.793134 0.0012162375 5.578187e-08 5.948276e-07 4 56467736 56467744 9 + 2.136 1.958 -0.597
ENSG00000174780 E004 408.095763 0.0025717212 5.332405e-10 8.313786e-09 4 56469653 56469773 121 + 2.489 2.322 -0.557
ENSG00000174780 E005 413.212006 0.0022855413 3.372112e-08 3.761845e-07 4 56471720 56471843 124 + 2.490 2.356 -0.447
ENSG00000174780 E006 409.767194 0.0026692884 1.401029e-04 7.039966e-04 4 56474054 56474197 144 + 2.480 2.404 -0.254
ENSG00000174780 E007 371.057646 0.0034001185 8.382516e-03 2.474473e-02 4 56474280 56474391 112 + 2.433 2.391 -0.138
ENSG00000174780 E008 4.429624 0.0036264405 1.566229e-03 5.849876e-03 4 56474392 56474508 117 + 0.495 1.014 2.132
ENSG00000174780 E009 11.105244 0.0015308577 3.469781e-01 4.911384e-01 4 56475677 56476670 994 + 0.966 0.891 -0.284
ENSG00000174780 E010 235.234113 0.0012735828 2.251586e-03 8.003831e-03 4 56476671 56476702 32 + 2.238 2.186 -0.174
ENSG00000174780 E011 9.353329 0.0028642186 4.596666e-01 5.997828e-01 4 56476703 56477172 470 + 0.896 0.841 -0.213
ENSG00000174780 E012 340.533996 0.0005126314 2.097244e-03 7.525649e-03 4 56478379 56478503 125 + 2.395 2.367 -0.091
ENSG00000174780 E013 273.262504 0.0007590408 2.224349e-04 1.059664e-03 4 56478592 56478649 58 + 2.303 2.240 -0.210
ENSG00000174780 E014 393.656240 0.0001279251 1.309912e-05 8.464930e-05 4 56483139 56483270 132 + 2.460 2.410 -0.167
ENSG00000174780 E015 370.526355 0.0002013332 4.196545e-02 9.466022e-02 4 56484736 56484864 129 + 2.425 2.433 0.029
ENSG00000174780 E016 1.048853 0.1674243373 1.000000e+00 1.000000e+00 4 56486228 56486324 97 + 0.244 0.265 0.157
ENSG00000174780 E017 251.452952 0.0030810323 8.364293e-01 8.976984e-01 4 56486325 56486397 73 + 2.250 2.299 0.165
ENSG00000174780 E018 264.077333 0.0002222046 3.057848e-01 4.479343e-01 4 56487949 56488013 65 + 2.275 2.305 0.101
ENSG00000174780 E019 1.139508 0.0116543654 3.424110e-01 4.864048e-01 4 56489062 56489387 326 + 0.211 0.431 1.441
ENSG00000174780 E020 311.461853 0.0001685182 7.478528e-01 8.352649e-01 4 56489388 56489483 96 + 2.344 2.397 0.176
ENSG00000174780 E021 358.640855 0.0001684416 6.406376e-01 7.538456e-01 4 56490333 56490436 104 + 2.401 2.475 0.246
ENSG00000174780 E022 333.931998 0.0001663078 7.174553e-01 8.128248e-01 4 56490568 56490645 78 + 2.370 2.441 0.238
ENSG00000174780 E023 439.255624 0.0014369277 8.652268e-01 9.171690e-01 4 56491431 56491568 138 + 2.491 2.546 0.182
ENSG00000174780 E024 1.699473 0.0083000928 7.415429e-01 8.306808e-01 4 56491569 56491683 115 + 0.327 0.431 0.591
ENSG00000174780 E025 3.038581 0.0059908173 4.156085e-03 1.358076e-02 4 56495271 56495356 86 + 0.376 0.891 2.301
ENSG00000174780 E026 259.255736 0.0012556714 7.892304e-01 8.650871e-01 4 56495357 56495394 38 + 2.264 2.315 0.170
ENSG00000174780 E027 1.471671 0.0301894783 5.404757e-01 6.716222e-01 4 56500451 56500535 85 + 0.273 0.432 0.960
ENSG00000174780 E028 434.577889 0.0008924368 1.297035e-01 2.337368e-01 4 56500536 56500695 160 + 2.480 2.580 0.336
ENSG00000174780 E029 1592.777211 0.0088405943 1.713824e-09 2.431702e-08 4 56501684 56503681 1998 + 3.000 3.289 0.959