ENSG00000174748

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000307839 ENSG00000174748 HEK293_OSMI2_2hA HEK293_TMG_2hB RPL15 protein_coding protein_coding 4031.197 7461.015 2672.047 294.0004 17.22583 -1.481423 283.9454 285.1465 368.9331 46.46042 14.77797 0.3716442 0.08684167 0.0388000 0.1380333 0.09923333 5.211331e-07 5.800019e-25 FALSE TRUE
ENST00000412097 ENSG00000174748 HEK293_OSMI2_2hA HEK293_TMG_2hB RPL15 protein_coding protein_coding 4031.197 7461.015 2672.047 294.0004 17.22583 -1.481423 890.8187 1895.5934 520.1761 124.44511 23.24945 -1.8655574 0.20777083 0.2535667 0.1948000 -0.05876667 1.410532e-02 5.800019e-25 FALSE TRUE
ENST00000645079 ENSG00000174748 HEK293_OSMI2_2hA HEK293_TMG_2hB RPL15 protein_coding protein_coding 4031.197 7461.015 2672.047 294.0004 17.22583 -1.481423 2535.7517 4669.4497 1582.5217 143.43456 26.72942 -1.5610212 0.62624167 0.6263333 0.5922000 -0.03413333 1.540356e-01 5.800019e-25 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000174748 E001 1.725407 8.341851e-03 3.757924e-01 5.202018e-01 3 23916591 23916768 178 + 0.509 0.331 -0.966
ENSG00000174748 E002 2.138123 1.306997e-02 4.590232e-02 1.018608e-01 3 23916804 23916978 175 + 0.690 0.331 -1.774
ENSG00000174748 E003 8.175759 2.049039e-03 3.303098e-01 4.739053e-01 3 23916979 23917095 117 + 0.996 0.850 -0.552
ENSG00000174748 E004 81.850382 3.381199e-04 1.391883e-02 3.804198e-02 3 23917096 23917131 36 + 1.766 1.851 0.285
ENSG00000174748 E005 103.208104 4.901119e-04 6.716848e-02 1.386431e-01 3 23917132 23917137 6 + 1.898 1.943 0.152
ENSG00000174748 E006 119.739449 5.554743e-04 1.835200e-01 3.056226e-01 3 23917138 23917138 1 + 1.981 2.001 0.067
ENSG00000174748 E007 1476.995511 3.855063e-04 6.642994e-03 2.029667e-02 3 23917139 23917146 8 + 3.140 3.070 -0.233
ENSG00000174748 E008 1478.986167 3.721362e-04 7.305139e-03 2.201312e-02 3 23917147 23917147 1 + 3.140 3.071 -0.231
ENSG00000174748 E009 9504.774671 1.787166e-03 6.893796e-02 1.416096e-01 3 23917148 23917173 26 + 3.889 3.898 0.030
ENSG00000174748 E010 1935.701946 6.108149e-04 2.304769e-01 3.630247e-01 3 23917174 23917239 66 + 3.242 3.193 -0.163
ENSG00000174748 E011 502.057607 6.976573e-04 2.538603e-02 6.267225e-02 3 23917240 23917268 29 + 2.681 2.600 -0.269
ENSG00000174748 E012 448.726840 1.166397e-03 1.392907e-02 3.806393e-02 3 23917269 23917295 27 + 2.641 2.548 -0.311
ENSG00000174748 E013 23.035205 8.881971e-04 2.947832e-26 3.586756e-24 3 23917296 23917298 3 + 1.762 0.971 -2.765
ENSG00000174748 E014 57.812656 4.749449e-04 4.371695e-44 1.912713e-41 3 23917299 23917444 146 + 2.106 1.423 -2.313
ENSG00000174748 E015 25.849222 7.679451e-03 7.617945e-15 2.553246e-13 3 23917445 23917532 88 + 1.749 1.107 -2.224
ENSG00000174748 E016 34.851349 1.225623e-02 7.249972e-12 1.543936e-10 3 23917533 23917665 133 + 1.846 1.277 -1.948
ENSG00000174748 E017 20.437899 1.116760e-02 4.218038e-11 7.926740e-10 3 23917666 23917704 39 + 1.648 1.034 -2.147
ENSG00000174748 E018 44.894145 2.286815e-03 1.418723e-14 4.574855e-13 3 23917705 23917836 132 + 1.898 1.429 -1.595
ENSG00000174748 E019 95.767563 3.489354e-04 1.542725e-01 2.674726e-01 3 23917837 23917849 13 + 1.971 1.880 -0.305
ENSG00000174748 E020 15017.813647 1.141742e-03 4.359758e-04 1.912791e-03 3 23917850 23917946 97 + 4.074 4.100 0.089
ENSG00000174748 E021 11391.417850 1.310802e-03 1.102777e-03 4.312294e-03 3 23917947 23917972 26 + 3.953 3.981 0.092
ENSG00000174748 E022 19122.097463 6.781826e-04 3.908565e-06 2.848493e-05 3 23917973 23918031 59 + 4.179 4.205 0.087
ENSG00000174748 E023 61.640747 8.132434e-04 8.064994e-20 5.014404e-18 3 23918032 23918439 408 + 2.024 1.565 -1.553
ENSG00000174748 E024 30463.649968 2.177319e-04 9.533048e-11 1.687542e-09 3 23918440 23918576 137 + 4.392 4.404 0.040
ENSG00000174748 E025 429.468758 7.193290e-02 2.107136e-01 3.393901e-01 3 23918577 23918583 7 + 2.381 2.590 0.697
ENSG00000174748 E026 128.520177 5.426671e-03 8.605903e-12 1.811917e-10 3 23918584 23919195 612 + 2.284 1.924 -1.207
ENSG00000174748 E027 20463.691854 3.486027e-05 1.725165e-22 1.458400e-20 3 23919196 23919202 7 + 4.224 4.229 0.019
ENSG00000174748 E028 24897.357409 3.929069e-05 8.724521e-43 3.554482e-40 3 23919203 23919246 44 + 4.298 4.317 0.064
ENSG00000174748 E029 29080.142494 4.995817e-04 1.093377e-05 7.199303e-05 3 23919247 23919506 260 + 4.372 4.384 0.041
ENSG00000174748 E030 11518.840488 2.144663e-02 9.019385e-13 2.231547e-11 3 23919507 23920989 1483 + 4.316 3.806 -1.692
ENSG00000174748 E031 113.019083 4.879518e-03 2.036749e-09 2.846176e-08 3 23921598 23924003 2406 + 2.205 1.886 -1.071
ENSG00000174748 E032 23.235242 3.044587e-02 1.292325e-01 2.331175e-01 3 23924004 23924374 371 + 1.452 1.265 -0.648