ENSG00000174738

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000312521 ENSG00000174738 HEK293_OSMI2_2hA HEK293_TMG_2hB NR1D2 protein_coding protein_coding 13.91914 3.091306 27.78341 0.1377137 0.8012956 3.163795 3.8843383 0.3198392 11.68533 0.03976494 0.7128821 5.148026 0.19379167 0.103066667 0.42190000 0.3188333 9.892238e-09 3.900868e-13 FALSE TRUE
MSTRG.22604.4 ENSG00000174738 HEK293_OSMI2_2hA HEK293_TMG_2hB NR1D2 protein_coding   13.91914 3.091306 27.78341 0.1377137 0.8012956 3.163795 8.6592419 2.7086429 12.84689 0.14439418 1.1378642 2.241584 0.73137917 0.875700000 0.46080000 -0.4149000 3.900868e-13 3.900868e-13 FALSE TRUE
MSTRG.22604.6 ENSG00000174738 HEK293_OSMI2_2hA HEK293_TMG_2hB NR1D2 protein_coding   13.91914 3.091306 27.78341 0.1377137 0.8012956 3.163795 0.7513695 0.0249128 1.76896 0.02491280 0.5025847 5.671134 0.03973333 0.008466667 0.06286667 0.0544000 3.219449e-02 3.900868e-13 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000174738 E001 16.8001289 0.0011592590 1.273884e-02 3.529763e-02 3 23945286 23945374 89 + 1.027 0.840 -0.705
ENSG00000174738 E002 40.0295378 0.0019806422 1.450603e-06 1.164114e-05 3 23945375 23945594 220 + 1.386 1.020 -1.299
ENSG00000174738 E003 0.1482932 0.0416039937 3.913372e-02   3 23946121 23946253 133 + 0.000 0.339 15.069
ENSG00000174738 E004 0.7686361 0.0627125851 1.059794e-02 3.020451e-02 3 23946648 23946680 33 + 0.071 0.656 4.305
ENSG00000174738 E005 54.7166971 0.0589812356 2.550288e-02 6.291680e-02 3 23954537 23954625 89 + 1.502 1.385 -0.402
ENSG00000174738 E006 125.3996719 0.0008280228 4.941877e-08 5.333089e-07 3 23954626 23954803 178 + 1.854 1.745 -0.369
ENSG00000174738 E007 98.2456347 0.0003292373 1.831184e-04 8.912325e-04 3 23956037 23956125 89 + 1.744 1.725 -0.065
ENSG00000174738 E008 99.7580237 0.0003015541 7.316954e-07 6.258974e-06 3 23959671 23959815 145 + 1.758 1.652 -0.361
ENSG00000174738 E009 1.3210886 0.4708317803 5.887626e-01 7.119296e-01 3 23959816 23959924 109 + 0.255 0.000 -11.054
ENSG00000174738 E010 289.5401013 0.0006360774 7.012856e-14 2.036114e-12 3 23961977 23962605 629 + 2.212 2.145 -0.222
ENSG00000174738 E011 1.6232010 0.0084525956 8.514990e-01 9.079260e-01 3 23963181 23963223 43 + 0.277 0.339 0.406
ENSG00000174738 E012 3.9255019 0.0039653048 5.761454e-01 7.016341e-01 3 23963224 23963330 107 + 0.498 0.528 0.143
ENSG00000174738 E013 1.6607648 0.0084335811 8.509170e-01 9.075759e-01 3 23964764 23964976 213 + 0.277 0.339 0.407
ENSG00000174738 E014 166.8936256 0.0078842830 8.352881e-03 2.467340e-02 3 23964977 23965162 186 + 1.965 2.015 0.170
ENSG00000174738 E015 151.3025153 0.0004556807 3.865793e-04 1.722842e-03 3 23967813 23968023 211 + 1.924 1.965 0.139
ENSG00000174738 E016 1077.7494724 0.0158978377 6.719947e-10 1.029662e-08 3 23977223 23980617 3395 + 2.727 3.114 1.286
ENSG00000174738 E017 0.8909948 0.0136968632 6.661618e-01 7.736543e-01 3 23992163 23992226 64 + 0.160 0.339 1.405