ENSG00000174718

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000312561 ENSG00000174718 HEK293_OSMI2_2hA HEK293_TMG_2hB RESF1 protein_coding protein_coding 5.240524 1.706579 7.98182 0.3020681 0.2508375 2.218988 3.0999216 0.4695884 5.81110396 0.08669512 0.21801273 3.6014242 0.5178083 0.2757667 0.727833333 0.4520667 3.975977e-14 3.975977e-14 FALSE TRUE
ENST00000540924 ENSG00000174718 HEK293_OSMI2_2hA HEK293_TMG_2hB RESF1 protein_coding protein_coding 5.240524 1.706579 7.98182 0.3020681 0.2508375 2.218988 0.8067519 0.3730392 1.27147571 0.18967436 0.14520630 1.7422422 0.1139500 0.1855000 0.158800000 -0.0267000 9.954807e-01 3.975977e-14   FALSE
ENST00000541981 ENSG00000174718 HEK293_OSMI2_2hA HEK293_TMG_2hB RESF1 protein_coding processed_transcript 5.240524 1.706579 7.98182 0.3020681 0.2508375 2.218988 0.2283499 0.2679464 0.07150135 0.26794642 0.03616858 -1.7699109 0.1035583 0.2419000 0.009233333 -0.2326667 9.504391e-01 3.975977e-14   FALSE
ENST00000543763 ENSG00000174718 HEK293_OSMI2_2hA HEK293_TMG_2hB RESF1 protein_coding retained_intron 5.240524 1.706579 7.98182 0.3020681 0.2508375 2.218988 0.6021517 0.5525189 0.61754539 0.28466981 0.15937569 0.1578182 0.2046875 0.2744000 0.077166667 -0.1972333 6.366346e-01 3.975977e-14   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000174718 E001 0.0000000       12 31959370 31959382 13 +      
ENSG00000174718 E002 0.5911862 0.0186038304 1.000000e+00 1.000000e+00 12 31959383 31959407 25 + 0.160 0.000 -8.619
ENSG00000174718 E003 0.5911862 0.0186038304 1.000000e+00 1.000000e+00 12 31959408 31959414 7 + 0.160 0.000 -10.084
ENSG00000174718 E004 7.9770451 0.0020876865 4.845093e-01 6.224920e-01 12 31959415 31959437 23 + 0.778 0.885 0.420
ENSG00000174718 E005 10.2665720 0.0016677860 2.483241e-01 3.839567e-01 12 31959438 31959448 11 + 0.865 1.023 0.593
ENSG00000174718 E006 13.2143112 0.0013487642 7.369384e-01 8.272446e-01 12 31959449 31959491 43 + 0.980 1.023 0.159
ENSG00000174718 E007 0.3666179 0.0271309138 1.215476e-01 2.221401e-01 12 31959663 31959900 238 + 0.046 0.291 3.107
ENSG00000174718 E008 19.4078081 0.0012184642 2.813108e-01 4.212025e-01 12 31960777 31960871 95 + 1.121 1.236 0.410
ENSG00000174718 E009 0.1472490 0.0430105342 6.544100e-01   12 31962489 31962544 56 + 0.046 0.000 -7.949
ENSG00000174718 E010 20.7172848 0.0049623592 8.025366e-01 8.742246e-01 12 31970189 31970356 168 + 1.159 1.185 0.092
ENSG00000174718 E011 29.9740699 0.0011045755 5.544630e-01 6.834465e-01 12 31980878 31981115 238 + 1.320 1.260 -0.210
ENSG00000174718 E012 385.0013065 0.0002776757 9.883437e-14 2.810549e-12 12 31981116 31985957 4842 + 2.419 2.275 -0.481
ENSG00000174718 E013 2.5623687 0.0064051307 8.546605e-01 9.100983e-01 12 31987166 31987238 73 + 0.426 0.464 0.196
ENSG00000174718 E014 26.9402430 0.0011659463 1.150773e-02 3.236722e-02 12 31987239 31987322 84 + 1.236 1.458 0.772
ENSG00000174718 E015 60.0852446 0.0004752969 9.448355e-15 3.117859e-13 12 31992378 31993107 730 + 1.530 1.939 1.386