ENSG00000174705

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000311601 ENSG00000174705 HEK293_OSMI2_2hA HEK293_TMG_2hB SH3PXD2B protein_coding protein_coding 8.255172 12.0155 6.868978 0.5100807 0.11514 -0.8058308 7.4072835 10.33999 6.463505 0.9591584 0.1544501 -0.6770105 0.90640000 0.8569667 0.9407667 0.0838 1.906979e-01 8.688825e-08 FALSE TRUE
ENST00000518522 ENSG00000174705 HEK293_OSMI2_2hA HEK293_TMG_2hB SH3PXD2B protein_coding protein_coding 8.255172 12.0155 6.868978 0.5100807 0.11514 -0.8058308 0.5595549 1.44766 0.000000 0.4484215 0.0000000 -7.1875104 0.05383333 0.1236000 0.0000000 -0.1236 2.803781e-07 8.688825e-08 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000174705 E001 0.3268771 0.0293111121 6.766324e-01   5 172325000 172325180 181 - 0.145 0.103 -0.570
ENSG00000174705 E002 1.1415968 0.0112325515 7.154287e-01 8.113488e-01 5 172325181 172325380 200 - 0.340 0.315 -0.157
ENSG00000174705 E003 169.0067793 0.0106434978 4.218588e-08 4.619113e-07 5 172333499 172333769 271 - 1.920 2.317 1.332
ENSG00000174705 E004 295.1675075 0.0068718073 3.327777e-13 8.782910e-12 5 172333770 172334116 347 - 2.159 2.558 1.334
ENSG00000174705 E005 1414.8635529 0.0034354280 6.210789e-01 7.380925e-01 5 172334117 172339916 5800 - 3.074 3.161 0.292
ENSG00000174705 E006 64.6398505 0.0003856753 9.700613e-05 5.080312e-04 5 172346136 172346261 126 - 1.857 1.761 -0.327
ENSG00000174705 E007 37.5099782 0.0088407906 4.843961e-02 1.064031e-01 5 172347283 172347332 50 - 1.609 1.546 -0.217
ENSG00000174705 E008 64.3610833 0.0025511655 3.805149e-02 8.744757e-02 5 172350363 172350589 227 - 1.809 1.782 -0.093
ENSG00000174705 E009 57.8629361 0.0009303531 1.471484e-03 5.544095e-03 5 172353888 172354005 118 - 1.793 1.714 -0.265
ENSG00000174705 E010 0.2214452 0.0404071799 8.221652e-01   5 172356691 172356774 84 - 0.000 0.103 8.219
ENSG00000174705 E011 53.8338100 0.0004742309 4.679792e-06 3.353096e-05 5 172358773 172358877 105 - 1.807 1.661 -0.491
ENSG00000174705 E012 68.8354629 0.0010410289 1.539683e-11 3.109684e-10 5 172362735 172362869 135 - 1.955 1.735 -0.742
ENSG00000174705 E013 37.1140659 0.0007275036 8.965922e-10 1.340939e-08 5 172373790 172373815 26 - 1.721 1.447 -0.936
ENSG00000174705 E014 51.6322266 0.0004850243 4.621191e-10 7.278606e-09 5 172382036 172382127 92 - 1.835 1.608 -0.771
ENSG00000174705 E015 42.8349472 0.0004858955 1.507838e-04 7.505396e-04 5 172394563 172394639 77 - 1.701 1.572 -0.438
ENSG00000174705 E016 33.5942375 0.0007037031 1.182145e-03 4.580768e-03 5 172406277 172406352 76 - 1.596 1.475 -0.416
ENSG00000174705 E017 29.1279848 0.0051304765 1.965963e-03 7.119703e-03 5 172422416 172422496 81 - 1.550 1.403 -0.505
ENSG00000174705 E018 21.6180799 0.0015478002 2.494547e-08 2.853771e-07 5 172454278 172454527 250 - 1.525 1.188 -1.174