ENSG00000174695

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000502346 ENSG00000174695 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM167A protein_coding protein_coding 38.20263 23.08237 63.60022 4.857291 0.5882794 1.461843 18.070934 5.937594 30.588033 0.6464261 0.893008 2.3630607 0.42940417 0.26780000 0.481266667 0.21346667 0.0000338383 3.38383e-05 FALSE FALSE
ENST00000503892 ENSG00000174695 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM167A protein_coding processed_transcript 38.20263 23.08237 63.60022 4.857291 0.5882794 1.461843 8.334613 6.022397 11.159578 0.8568569 1.028289 0.8887714 0.22792917 0.27133333 0.175200000 -0.09613333 0.1329142533 3.38383e-05   FALSE
ENST00000504622 ENSG00000174695 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM167A protein_coding processed_transcript 38.20263 23.08237 63.60022 4.857291 0.5882794 1.461843 5.268735 1.380016 13.267869 0.7942092 1.780081 3.2558504 0.11895417 0.05103333 0.208300000 0.15726667 0.2642845907 3.38383e-05   FALSE
ENST00000511118 ENSG00000174695 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM167A protein_coding retained_intron 38.20263 23.08237 63.60022 4.857291 0.5882794 1.461843 5.213656 7.699912 7.792679 1.6949530 1.437007 0.0172552 0.16785417 0.33233333 0.122900000 -0.20943333 0.0001174432 3.38383e-05   FALSE
MSTRG.26519.1 ENSG00000174695 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM167A protein_coding   38.20263 23.08237 63.60022 4.857291 0.5882794 1.461843 1.172006 2.042447 0.531662 1.0580776 0.531662 -1.9218805 0.05337083 0.07746667 0.008233333 -0.06923333 0.1041244367 3.38383e-05   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000174695 E001 1.9508155 0.0085513602 1.715292e-05 1.080165e-04 5 83023265 83023445 181 - 0.140 0.817 3.870
ENSG00000174695 E002 490.0044863 0.0025835489 4.876187e-01 6.252735e-01 5 83052846 83054061 1216 - 2.672 2.598 -0.248
ENSG00000174695 E003 1016.7214598 0.0032327377 5.951359e-15 2.025997e-13 5 83054062 83056534 2473 - 3.027 2.776 -0.836
ENSG00000174695 E004 252.1736373 0.0019086869 4.075852e-04 1.803559e-03 5 83056535 83056726 192 - 2.347 2.412 0.219
ENSG00000174695 E005 116.9129367 0.0002622692 5.038807e-03 1.603674e-02 5 83056727 83056766 40 - 2.019 2.076 0.190
ENSG00000174695 E006 275.0427098 0.0004690729 2.304439e-05 1.408378e-04 5 83056767 83056883 117 - 2.388 2.447 0.199
ENSG00000174695 E007 595.0298130 0.0001997229 1.899663e-09 2.671160e-08 5 83056884 83057154 271 - 2.724 2.774 0.164
ENSG00000174695 E008 250.9021698 0.0019508167 3.403821e-02 7.983262e-02 5 83061877 83061911 35 - 2.358 2.380 0.075
ENSG00000174695 E009 1.7927124 0.3113506913 7.000653e-01 7.996266e-01 5 83061912 83061975 64 - 0.464 0.318 -0.823
ENSG00000174695 E010 337.7572831 0.0007577252 7.873319e-04 3.213912e-03 5 83065008 83065117 110 - 2.483 2.519 0.119
ENSG00000174695 E011 0.3030308 0.3720181489 1.000000e+00   5 83071363 83071430 68 - 0.141 0.000 -8.501
ENSG00000174695 E012 206.5665426 0.0027933419 1.505119e-01 2.623765e-01 5 83077321 83077453 133 - 2.279 2.291 0.041
ENSG00000174695 E013 0.7394793 0.0153787590 8.914574e-01 9.346870e-01 5 83077718 83077863 146 - 0.246 0.192 -0.450