ENSG00000174669

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000357440 ENSG00000174669 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC29A2 protein_coding protein_coding 25.52721 28.4434 21.12652 1.964899 0.622151 -0.4288632 6.8993446 8.092363 5.342626 1.7166385 0.79947363 -0.59809583 0.2667167 0.27916667 0.25370000 -0.02546667 9.030282e-01 5.467579e-08 FALSE  
ENST00000541567 ENSG00000174669 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC29A2 protein_coding nonsense_mediated_decay 25.52721 28.4434 21.12652 1.964899 0.622151 -0.4288632 0.6067535 1.705475 0.000000 1.1465829 0.00000000 -7.42246462 0.0251625 0.06600000 0.00000000 -0.06600000 2.061380e-01 5.467579e-08 FALSE  
ENST00000619145 ENSG00000174669 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC29A2 protein_coding protein_coding 25.52721 28.4434 21.12652 1.964899 0.622151 -0.4288632 3.0404153 3.694630 2.451989 0.7544165 0.13377265 -0.58950522 0.1161083 0.12783333 0.11626667 -0.01156667 8.773706e-01 5.467579e-08 FALSE  
MSTRG.5772.14 ENSG00000174669 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC29A2 protein_coding   25.52721 28.4434 21.12652 1.964899 0.622151 -0.4288632 3.5492208 2.037700 3.490073 0.1947353 0.15781331 0.77338043 0.1429833 0.07146667 0.16540000 0.09393333 5.467579e-08 5.467579e-08    
MSTRG.5772.17 ENSG00000174669 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC29A2 protein_coding   25.52721 28.4434 21.12652 1.964899 0.622151 -0.4288632 4.7879827 4.590064 4.554037 0.3828145 0.02945756 -0.01134351 0.1900792 0.16106667 0.21586667 0.05480000 1.770486e-02 5.467579e-08 FALSE  
MSTRG.5772.2 ENSG00000174669 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC29A2 protein_coding   25.52721 28.4434 21.12652 1.964899 0.622151 -0.4288632 1.3446766 1.211299 1.261384 0.2728623 0.17972030 0.05798370 0.0533500 0.04370000 0.05953333 0.01583333 6.233739e-01 5.467579e-08    
MSTRG.5772.4 ENSG00000174669 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC29A2 protein_coding   25.52721 28.4434 21.12652 1.964899 0.622151 -0.4288632 3.3295632 5.194273 2.135667 0.1717656 0.47947019 -1.27827073 0.1280917 0.18360000 0.09996667 -0.08363333 3.661916e-02 5.467579e-08 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000174669 E001 20.074883 0.0108396986 8.135631e-10 1.226345e-08 11 66360351 66362198 1848 - 1.566 1.027 -1.891
ENSG00000174669 E002 6.257886 0.0040460211 1.202163e-05 7.840610e-05 11 66362199 66362474 276 - 1.098 0.564 -2.114
ENSG00000174669 E003 4.280375 0.0037022163 2.663976e-04 1.242754e-03 11 66362475 66362520 46 - 0.952 0.457 -2.093
ENSG00000174669 E004 4.159062 0.0048631093 2.241825e-03 7.972575e-03 11 66362521 66362521 1 - 0.912 0.496 -1.748
ENSG00000174669 E005 3.717201 0.0132585736 1.572257e-02 4.211097e-02 11 66362522 66362522 1 - 0.843 0.496 -1.483
ENSG00000174669 E006 420.271358 0.0039173620 3.995426e-07 3.602672e-06 11 66362523 66363138 616 - 2.476 2.664 0.626
ENSG00000174669 E007 318.679796 0.0054844004 3.656738e-02 8.465198e-02 11 66363139 66363495 357 - 2.413 2.521 0.359
ENSG00000174669 E008 81.578612 0.0121221704 5.863559e-01 7.099313e-01 11 66363496 66363496 1 - 1.859 1.921 0.210
ENSG00000174669 E009 114.680243 0.0058468318 3.661269e-01 5.104597e-01 11 66363497 66363547 51 - 1.999 2.069 0.235
ENSG00000174669 E010 211.096144 0.0002627228 4.256266e-01 5.685436e-01 11 66364225 66364424 200 - 2.279 2.320 0.137
ENSG00000174669 E011 11.083428 0.0380183818 1.863202e-01 3.091254e-01 11 66364425 66364751 327 - 1.161 1.010 -0.549
ENSG00000174669 E012 152.159817 0.0003209588 9.101242e-01 9.468701e-01 11 66365936 66366021 86 - 2.144 2.168 0.080
ENSG00000174669 E013 15.893940 0.0289040251 2.714818e-02 6.629980e-02 11 66366022 66366125 104 - 1.351 1.112 -0.846
ENSG00000174669 E014 144.517997 0.0010880870 9.513062e-01 9.735445e-01 11 66366126 66366191 66 - 2.125 2.145 0.064
ENSG00000174669 E015 93.762843 0.0009548646 8.232832e-01 8.886373e-01 11 66366192 66366231 40 - 1.943 1.955 0.040
ENSG00000174669 E016 36.896136 0.0029334047 9.128235e-05 4.810035e-04 11 66366232 66366430 199 - 1.688 1.466 -0.756
ENSG00000174669 E017 143.328125 0.0033037858 6.366924e-01 7.506486e-01 11 66366431 66366564 134 - 2.110 2.151 0.139
ENSG00000174669 E018 50.292204 0.0005160028 1.029818e-16 4.423943e-15 11 66366565 66367052 488 - 1.897 1.507 -1.323
ENSG00000174669 E019 165.121547 0.0008976314 2.155196e-01 3.450393e-01 11 66367464 66367548 85 - 2.159 2.218 0.198
ENSG00000174669 E020 156.138080 0.0003537808 6.236627e-01 7.401912e-01 11 66367772 66367869 98 - 2.149 2.184 0.118
ENSG00000174669 E021 156.719889 0.0057394009 2.811928e-01 4.210746e-01 11 66368537 66368671 135 - 2.190 2.166 -0.081
ENSG00000174669 E022 103.085141 0.0003410970 1.000996e-05 6.651785e-05 11 66368672 66369059 388 - 2.076 1.941 -0.453
ENSG00000174669 E023 97.838871 0.0003563726 1.637135e-04 8.079988e-04 11 66369060 66369131 72 - 2.041 1.925 -0.391
ENSG00000174669 E024 45.076746 0.0006697399 4.930902e-02 1.079399e-01 11 66369132 66369134 3 - 1.691 1.607 -0.288
ENSG00000174669 E025 70.802397 0.0003766572 2.365085e-02 5.909187e-02 11 66369135 66369199 65 - 1.880 1.803 -0.257
ENSG00000174669 E026 46.083102 0.0005050260 6.610131e-01 7.695622e-01 11 66369200 66369368 169 - 1.651 1.648 -0.011
ENSG00000174669 E027 112.653495 0.0038629383 2.235945e-01 3.546937e-01 11 66369369 66369532 164 - 2.051 2.020 -0.104
ENSG00000174669 E028 56.496619 0.0004218615 5.480683e-01 6.779709e-01 11 66371244 66371325 82 - 1.702 1.751 0.168
ENSG00000174669 E029 44.876448 0.0015439941 4.851020e-01 6.230500e-01 11 66371563 66371611 49 - 1.593 1.654 0.206
ENSG00000174669 E030 30.183954 0.0065347159 9.255022e-01 9.570924e-01 11 66371612 66371646 35 - 1.454 1.470 0.054
ENSG00000174669 E031 31.067366 0.0052094659 3.494817e-01 4.936839e-01 11 66371647 66371779 133 - 1.416 1.507 0.312
ENSG00000174669 E032 4.090975 0.0917844309 8.345650e-01 8.964390e-01 11 66371780 66371820 41 - 0.661 0.701 0.170
ENSG00000174669 E033 3.645091 0.0044178812 5.427896e-01 6.735037e-01 11 66372010 66372214 205 - 0.697 0.623 -0.316
ENSG00000174669 E034 0.000000       11 66374883 66374920 38 -