ENSG00000174607

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000310836 ENSG00000174607 HEK293_OSMI2_2hA HEK293_TMG_2hB UGT8 protein_coding protein_coding 6.123024 2.73126 7.428453 0.2875559 0.3294069 1.440163 3.9372613 2.329239 3.8919502 0.3719421 0.2824444 0.7381562 0.71287083 0.8456667 0.52926667 -0.31640000 0.03149445 0.03149445 FALSE TRUE
MSTRG.25341.1 ENSG00000174607 HEK293_OSMI2_2hA HEK293_TMG_2hB UGT8 protein_coding   6.123024 2.73126 7.428453 0.2875559 0.3294069 1.440163 1.6876342 0.361002 3.0410583 0.1703446 0.3156132 3.0398110 0.23271667 0.1376667 0.40900000 0.27133333 0.07323167 0.03149445 FALSE TRUE
MSTRG.25341.3 ENSG00000174607 HEK293_OSMI2_2hA HEK293_TMG_2hB UGT8 protein_coding   6.123024 2.73126 7.428453 0.2875559 0.3294069 1.440163 0.3308467 0.000000 0.4954441 0.0000000 0.4954441 5.6594797 0.03312917 0.0000000 0.06173333 0.06173333 0.98408495 0.03149445 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000174607 E001 8.054481 0.0020574742 1.227891e-05 7.991074e-05 4 114598647 114598769 123 + 1.058 0.407 -2.744
ENSG00000174607 E002 11.564886 0.0017681867 2.618649e-04 1.224201e-03 4 114598770 114598806 37 + 1.173 0.753 -1.575
ENSG00000174607 E003 29.179864 0.0007407062 8.492366e-04 3.434932e-03 4 114598807 114598974 168 + 1.517 1.293 -0.774
ENSG00000174607 E004 6.148068 0.0936987732 7.279192e-02 1.479931e-01 4 114619423 114619525 103 + 0.921 0.553 -1.512
ENSG00000174607 E005 0.000000       4 114622367 114622878 512 +      
ENSG00000174607 E006 115.202797 0.0060762438 1.391452e-03 5.278568e-03 4 114622879 114623702 824 + 2.077 1.940 -0.459
ENSG00000174607 E007 50.352545 0.0005131374 4.393742e-01 5.811258e-01 4 114663995 114664137 143 + 1.690 1.668 -0.075
ENSG00000174607 E008 42.785943 0.0004993342 1.968554e-01 3.223029e-01 4 114665680 114665756 77 + 1.632 1.577 -0.187
ENSG00000174607 E009 61.209449 0.0004914382 1.654016e-02 4.392878e-02 4 114668085 114668304 220 + 1.797 1.701 -0.326
ENSG00000174607 E010 41.870321 0.0006088859 2.538271e-01 3.904384e-01 4 114675925 114676070 146 + 1.624 1.577 -0.159
ENSG00000174607 E011 264.834088 0.0019386333 1.134279e-16 4.841951e-15 4 114676071 114678225 2155 + 2.328 2.517 0.628
ENSG00000174607 E012 0.000000       4 114716991 114717170 180 +